A5101622619- Traumatic Brain Injury and Neurovascular Disturbances
- Immunotherapy and Immune Responses
- Cardiac Imaging and Diagnostics
- Sepsis Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Advanced MRI Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Nanoparticle-Based Drug Delivery
- Phagocytosis and Immune Regulation
- Traumatic Brain Injury Research
- Cardiac Valve Diseases and Treatments
- Head and Neck Cancer Studies
- Respiratory Support and Mechanisms
- Cardiomyopathy and Myosin Studies
- Heart Rate Variability and Autonomic Control
- Intensive Care Unit Cognitive Disorders
- Machine Learning in Healthcare
- Neurological disorders and treatments
- Glaucoma and retinal disorders
- Hemodynamic Monitoring and Therapy
- Aortic Disease and Treatment Approaches
- NF-κB Signaling Pathways
- Lung Cancer Treatments and Mutations
- Retinoids in leukemia and cellular processes
Kyung Hee University
2025
Duke Medical Center
2008-2024
Johns Hopkins Medicine
2020-2023
Johns Hopkins University
2019-2023
Calumet College of Saint Joseph
2023
Soonchunhyang University
2019-2023
Kaiser Permanente Stockton Medical Offices
2020-2022
University of Baltimore
2022
United States Congress
2022
Intensive Care Society
2022
<h3>Importance</h3> Discrepancies in oxygen saturation measured by pulse oximetry (Spo<sub>2</sub>), when compared with arterial (Sao<sub>2</sub>) blood gas (ABG), may differentially affect patients according to race and ethnicity. However, the association of these disparities health outcomes is unknown. <h3>Objective</h3> To examine racial ethnic discrepancies between Sao<sub>2</sub>and Spo<sub>2</sub>measures their associations clinical outcomes. <h3>Design, Setting, Participants</h3> This...
PURPOSE: Earlier detection of head and neck cancer recurrence may improve survival. We evaluated the ability [ 18 F]fluorodeoxyglucose positron emission tomography (FDG-PET) to detect in a prospective trial using sequential PET scans. PATIENTS AND METHODS: Serial posttherapy FDG-PET was prospectively performed 44 patients with stage III or IV cancer. twice during first posttreatment year (at 2 10 months after therapy) thereafter as needed. After therapy, were grouped, based on tissue...
Abstract Costimulatory receptors such as glucocorticoid-induced tumor necrosis factor receptor–related protein (GITR) play key roles in regulating the effector functions of T cells. In human clinical trials, however, GITR agonist antibodies have shown limited therapeutic effect, which may be due to suboptimal receptor clustering-mediated signaling. To overcome this potential limitation, a rational engineering approach is needed optimize agonist-based immunotherapies. Here we show bispecific...
Background [F-18]Fluorodeoxyglucose (FDG)-positron emission tomography (PET) can measure the metabolic activity of tissues; FDG-PET may be able to predict response chemotherapy by identifying changes in tumor metabolism. Measurement treatment help improve survival management advanced head and neck cancer. We evaluated this particular use patients participating a neoadjuvant organ-preservation protocol using taxol carboplatin compared pathologic after with metabolism measured FDG-PET. Methods...
ABSTRACT The objective of this analysis was to investigate the demographic differences between women who report postpartum depression symptoms (PPDS) and seek help versus those but do not help, using data from Utah Pregnancy Risk Assessment Monitoring System (PRAMS) 2004 dataset. Overall, 14.7% reported experiencing PPDS in 2004. Sixty percent having did Seeking for during pregnancy associated with help‐seeking behavior (adjusted odds ratio [aOR] = 0.1; 95% confidence interval [CI],...
Transcatheter aortic valve implantation (TAVI) has demonstrated the feasibility of treating valvular heart disease with transcatheter therapy.On back this success, various concepts are being evaluated to treat other disease, especially mitral regurgitation (MR).The currently approved MR replicate surgical repair.However, most them cannot eliminate completely.Similar TAVI, a may provide valuable alternative.The FORTIS (Edwards Lifesciences, Irvine, CA, USA) is self-expanding device implanted...
Schwann cells (SCs), which produce neurotropic factors and adhesive molecules, have been reported previously to contribute structural support guidance during axonal regeneration; therefore, they are potentially a crucial target in the restoration of injured nervous tissues. Autologous SC transplantation has performed shown promising clinical results for treating nerve injuries donor site morbidity, insufficient production considered as major issue. Here, we differentiation tonsil-derived...
Background Delirium poses significant risks to patients, but countermeasures can be taken mitigate negative outcomes. Accurately forecasting delirium in intensive care unit (ICU) patients could guide proactive intervention. Our primary objective was predict ICU by applying machine learning clinical and physiologic data routinely collected electronic health records. Methods Two prediction models were trained tested using a multicenter database (years of collection 2014 2015), externally...
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Agonistic CD40 monoclonal antibodies (mAb) have demonstrated some clinical activity, but with dose-limiting toxicity. To reduce systemic toxicity, we developed a bispecific molecule that was maximally active in the presence of tumor antigen and had limited activity absence antigen. LB-1 is containing single-chain Fv domains targeting mouse mesothelin. exhibited enhanced upon binding to cell-surface mesothelin less potent binding. In model implanted syngeneic 4T1 tumors expressing mesothelin,...
Background: The common intronic deletion, MYBPC3 Δ25 , detected in 4% to 8% of South Asian populations, is reported be associated with cardiomyopathy, ≈7-fold increased risk disease variant carriers. Here, we examine the contribution hypertrophic cardiomyopathy (HCM) a large patient cohort. Methods: Sequence data from 2 HCM cohorts (n=5393) was analyzed determine frequency and co-occurrence pathogenic variants genes. Case-control haplotype analyses were performed compare frequencies assess...
To determine the prevalence and prognostic significance of unrecognized myocardial infarction (MI) by delayed-enhancement MRI (DE-MRI) in asymptomatic patients with diabetes.In this prospective, two-center study without known cardiac disease (n = 120), two prespecified cohorts underwent a research MRI: 1) high-risk group type 1 diabetes chronic renal insufficiency 50) 2) an average-risk 2 70). The primary end point was composite all-cause mortality clinical MI.Overall, MI 19% DE-MRI (28% 13%...
The receptor for the cytokine TWEAK (TweakR) is a cell surface member of tumor necrosis factor superfamily with diverse biological roles. TNFRSF family members are appealing therapeutic targets in oncology due to their aberrant expression and function cells. goal current study was examine potential TweakR as target breast cancer.Expression primary cancer tissues metastases characterized using immunohistochemistry. To determine functional relevance TweakR, lines were treated vitro vivo...