The anti-atherogenic effects of spirulina (Spirulina platensis) were investigated in the New Zealand White (NZW) rabbit model. animal had hypercholesterolemia induced by being fed a high cholesterol diet (HCD) containing 0.5% for 4 wk, and then HCD supplemented with 1 or 5% (SP1 SP5) an additional 8 wk. Spirulina supplementation lowered intimal surface aorta 32.2 to 48.3%, compared HCD. Serum triglyceride (TG) total (TC) significantly reduced SP groups. After serum low density lipoprotein...

Ultraviolet B (UVB) radiation-induced oxidative skin cell damage is a major cause of photoaging. In the present study, low molecular weight fucoidan fraction (SHC4) was obtained from Sargassum horneri by Celluclast-assisted extraction, followed step gradient ethanol precipitation. The protective effect SHC4 investigated in human keratinocytes against UVB-induced stress. purified characterized Fourier-transform infrared spectroscopy (FTIR), 1H nuclear magnetic resonance (NMR), agarose...

Antimicrobial peptides (AMPs), also called host defense peptides, particularly those with amphipathic helical structures, are emerging as target molecules for therapeutic development due to their immunomodulatory properties. Although the antimicrobial activity of AMPs is known be exerted primarily by permeation bacterial membrane, mechanism underlying its anti-inflammatory remains elucidated. We report potent WALK11.3, an model peptide conformation, in lipopolysaccharide (LPS)-stimulated...

Meretrix lusoria (M. lusoria) is an economically important shellfish which widely distributed in South Eastern Asia that contains bioactive peptides, proteins, and enzymes. In the present study, extracted meat content of M. was enzymatic hydrolyzed using four different commercial proteases (neutrase, protamex, alcalase, flavourzyme). Among hydrolysates, protamex hydrolysate (MLPH) fraction with MW ≤ 1 kDa exhibited highest free radical scavenging ability. The MLPH further purified amino acid...

Sargassum horneri is used as a traditional medicinal agent and exhibits various pharmacological effects. In this study, we found that the 70% EtOH extract contained 34.37 ± 0.75 μg/mg fucosterol. We tested antioxidant activities of extracts their fractions. The CH2Cl2-soluble fraction showed strongest DPPH ABTS radical scavenging activities. Next, evaluated anti-neuroinflammatory effects S. on lipopolysaccharide (LPS)-stimulated BV2 cells. Pretreatment with fractions suppressed LPS-induced...

Obesity is acknowledged as a significant risk factor for cardiovascular disease, often accompanied by increased inflammation and diabetes. Bioactive peptides derived from marine animal proteins show promise safe effective anti-obesity agents regulating adipocyte differentiation through the AMPK signaling pathway. Therefore, this study aims to investigate anti-diabetic effects of bioactive compounds Meretrix lusoria Protamex enzymatic hydrolysate (MLP) fraction (≤1 kDa) 6-week treatment (150...

The beneficial effect of Spirulina (Spirulina platensis) on tissue lipid peroxidation and oxidative DNA damage was tested in the hypercholesterolemic New Zealand White rabbit model. After hypercholesterolemia induced by feeding a high cholesterol (0.5%) diet (HCD) for 4 weeks, then HCD supplemented with 1% or 5% (SP1 SP5, respectively) provided an additional 8 weeks. supplementation significantly reduced increased level HCD-fed rabbits, levels recovered to control values. Oxidative stress...

A novel anticancer peptide was purified from Crassostrea gigas and investigated for its cytotoxic activity. To prepare the peptide, eight proteases were employed enzymatic hydrolysis. Flavourzyme hydrolysate, which showed clearly superior activity on prostate cancer cells, further using a membrane system consecutive chromatographic methods. Finally, obtained, sequence partially as His-Phe-Asn-Ile-Gly-Asn-Arg-Cys-Leu-Cys at N-terminus. The C. effectively induced death of prostate, breast,...

Scope Molecular mechanisms for the potential antihyperglycemic effect of equol remain to be elucidated. In this study, we investigated in vitro on glucose uptake, AMP‐activated protein kinase (AMPK) phosphorylation, and transporter 4 (GLUT4) translocation plasma membrane L6 myocytes, its vivo obese‐diabetic model ob / mice. Methods results Equol was found promote AMPK GLUT4 detected by Western blotting analyses myotubes under a condition insulin absence. (0.05% diet) suppressed rise serum...

Lycium barbarum and scopoletin are widely used in oriental Eastern medicine often consumed as teas. In this study, proinflammatory cytokines expressed human keratinocytes (HaCaT) were induced by skin diseases caused 2,4-dinitrochlorobenzene (DNCB) tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ). The inhibitory activity of L. EtOH extract (LBE) on chemokines was investigated. the DNCB-induced animal model, oral administration LBE inhibited lesions showed effects vitro....

Here, we introduce a means of utilizing waste oyster shells which were obtained from temporary storage near coastal workplaces as CO2 adsorbents. The calcined CaO can be easily dissociated to Ca2+ cation and CO32− anion by hydrolysis gas-liquid carbonation reaction converted precipitated calcium carbonate (PCC) in algae-containing water. hydroxide combination water significantly contributed improving quality is very dependent on the addition amount powders. Key words: Carbon dioxide,...

In recent years, growth hormone deficiency in children has been treated with therapy despite the possible significant side effects. Therefore, it was deemed beneficial to develop functional foods or dietary supplements for safely improving children’s growth. Spirulina platensis is known its high antioxidant, anti-aging, anti-cancer, and immunity-enhancing properties, as well digestibility protein content, but little reported about influence on bone development a normal supply of protein....

Mullet, a coastal fish species, is commonly used as salted dried in many countries, including Korea, Japan, and the southeastern United States. The purpose of this investigation was to develop high-quality products semi-dried mullet (SSDM) using natural salt Salicornia herbacea L. (SAL). antioxidant activity SAL investigated by vitro studies. physicochemical nutritional characteristics fresh (FM), control (SSDM-CON), SAL-treated (SSDM-SAL) groups were analyzed. moisture, ash, crude protein...

Abstract The present study aimed to evaluate the protective effect of a methanol extract Sargassum horneri (SHM), which contains 6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one (HTT) and apo-9′-fucoxanthinone, against ultraviolet B (UVB)-induced cellular damage in human keratinocytes its underlying mechanism. SHM significantly improved cell viability UVB-exposed by reducing generation intracellular reactive oxygen species (ROS). Moreover, inhibited UVB exposure-induced...

Daily consumption of an antioxidant-rich leafy vegetable mix (LVM) was assessed for beneficial effects on plasma lipid profiles, tissue peroxidation, and oxidative DNA damage in C57BL/6J mice fed a high fat cholesterol diet (20% 1% cholesterol, wt/wt) 4 weeks. The LVM contained beet leaf, angelica, red leaf lettuce, dandelion, green cos lollo rosso, romaine lettuce (12.5%, respectively), scotch kale, kale (6.25%, respectively). (n = 16) were randomly divided into either the control (high...

The present study was conducted to determine the effect of supplementation with oriental herbal medicine residue (OHMR) and methyl sulfonyl methane (MSM) on growth performance meat quality ducks during a 42-day feeding period. In total, 270 Cherry Valley male ducklings were fed diets supplemented 0.03% MSM alone (MSM group) combination 0.5% OHMR (MSM–OHMR group). Supplementing diet resulted in significant (P < 0.05) decrease mortality rate serum total cholesterol concentration, an...

[Purpose] In this study, we examined the in vitro antioxidant activities and laxative effects of taurine-xylose (T-X), a synthetic taurine-carbohydrate derivative, rat model constipation induced by loperamide. [Methods] The animals were divided into four treatment groups: normal untreated rats (NOR group), loperamide-treated control (CON loperamide (15 mg/kg)-treated (T-X commercial Dulcolax S (5.5 (DS group). [Results] present T-X exhibited potent reducing power free radical scavenging for...

Ribes diacanthum Pall (RDP) is a Mongolian traditional medicine used to treat renal inflammation. In the present study, we initially investigated anti-inflammatory effects and mechanisms of action ethylacetate extract RDP (EARDP) in RAW 264.7 macrophages stimulated by lipopolysaccharide (LPS) 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced dermatitis mice. We demonstrated that EARDP protected against LPS-induced cell death inhibiting intracellular reactive oxygen species (ROS)...

Lycopus maackianus Makino belongs to the Labiatae family and is used in traditional medicine manage postpartum edema boils. However, few studies on its antioxidant anti-inflammatory effects have been conducted. Here, compounds L. methanol (MeOH) extract were profiled using ultra-high-performance liquid chromatography-time-of-flight high-resolution mass spectrometry analysis. The activity of MeOH was shown increase a concentration-dependent manner by investigating...