A5100682704- Ginseng Biological Effects and Applications
- Bee Products Chemical Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Bioactive natural compounds
- Ziziphus Jujuba Studies and Applications
- Exercise and Physiological Responses
- Plant-based Medicinal Research
- Eicosanoids and Hypertension Pharmacology
- Phytochemistry and Bioactive Compounds
- Pharmacology and Obesity Treatment
- Legume Nitrogen Fixing Symbiosis
- Plant Pathogenic Bacteria Studies
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Alkaloids: synthesis and pharmacology
- Neurological Disease Mechanisms and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammation biomarkers and pathways
- Bacterial biofilms and quorum sensing
- Macrophage Migration Inhibitory Factor
- Pharmacological Effects of Natural Compounds
- Sphingolipid Metabolism and Signaling
- Insect Utilization and Effects
Chosun University
2021-2023
Kyungpook National University
2022
Hope Center for Neurological Disorders
2020
Korea Food Research Institute
2019
Seoul National University
2009
Alzheimer's disease (AD) is characterized by plaques containing amyloid-β (Aβ) and neurofibrillary tangles composed of aggregated, hyperphosphorylated tau. Beyond tau Aβ, evidence suggests that microglia play an important role in AD pathogenesis. Rare variants the microglia-expressed triggering receptor expressed on myeloid cells 2 (TREM2) gene increase risk 2- to 4-fold. It likely these TREM2 decreasing response Aβ its local toxicity. However, neocortical pathology occurs many years before...
Quorum sensing (QS) plays important roles in the pathogenicity of Burkholderia glumae, causative agent bacterial rice grain rot. We determined how QS is involved catalase expression B. glumae. The QS-defective mutant glumae exhibited less activity than wild-type A beta-glucuronidase assay a katG::Tn3-gusA78 reporter fusion protein revealed that katG under control QS. Furthermore, was upregulated by QsmR, transcriptional activator for flagellar-gene regulated gel mobility shift confirmed QsmR...
Sargassum horneri is used as a traditional medicinal agent and exhibits various pharmacological effects. In this study, we found that the 70% EtOH extract contained 34.37 ± 0.75 μg/mg fucosterol. We tested antioxidant activities of extracts their fractions. The CH2Cl2-soluble fraction showed strongest DPPH ABTS radical scavenging activities. Next, evaluated anti-neuroinflammatory effects S. on lipopolysaccharide (LPS)-stimulated BV2 cells. Pretreatment with fractions suppressed LPS-induced...
Neuroinflammation activated by microglia affects inflammatory pain development. This study aimed to explore the anti-inflammatory properties and mechanisms of 1,6,7-trihydroxy-2-(1,1-dimethyl-2-propenyl)-3-methoxyxanthone (THMX) from Cudrania tricuspidata in activation-mediated pain. In RAW 264.7 BV2 cells, THMX has been shown reduce lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), pro-inflammatory mediators cytokines, including (NO),...
The mealworm (Tenebrio molitor) is now considered to be an alternative source of protein. An enzymatical digestion process may necessary increase the biological absorption, distribution, and metabolism Tenebrio molitor maximize its functional activities. In this study, we acquired enzymatically hydrolyzed defatted molitors using water extract (WE), pressure (P), high (HP) processes. nutritional content was significantly altered by applying molitors. crude ash carbohydrate decreased, but...
Cornuside (CNS), found in the fruit of Cornus officinalis Seib, is a natural bisiridoid glucoside that possesses therapeutic effects by suppressing inflammation. This study aimed to determine whether CNS could inhibit inflammatory response induced lipopolysaccharide (LPS) human umbilical vein endothelial cells (HUVECs) and mice, as well decipher mechanisms. After activating HUVECs with LPS, were treated CNS. Cells then isolated for protein or mRNA assays analyze signaling molecules. In...
Fine particulate matter (PM2.5) is an air pollutant that causes severe lung injury. We investigated the effects of Jujuboside B (JB), a component Zizyphi Spinosi Semen, on toxicity caused by PM2.5, and we identified mechanism its protective effect. Lung injury in animal model was induced intratracheal administration PM2.5 suspension. After 2 days pretreatment, mice were administered JB via tail vein three times over 2-day period. significantly reduced histological damage as well wet/dry...