Obesity is a significant global health concern that not only increases metabolic disorders risks but also impacts mental health, particularly affecting women due to hormonal fluctuations and societal pressures. This study investigated anti-obesity anti-anxiety effects of lemon balm (Melissa officinalis) extracts in female C57BL/6 mouse (n = 16, 17 weeks old) fed high-fat diet (HFD). We compared 2 method: distilled water (LBD, n 5) 80% ethanol (LBE, 6), administered via oral gavage (200...

The swelling of secretory vesicles has been implicated in exocytosis, but the underlying mechanism vesicle remains largely unknown. Zymogen granules (ZGs), membrane-bound exocrine pancreas, swell response to GTP mediated by a G α i3 protein. Evidence is presented here that water channel aquaporin-1 (AQP1) present ZG membrane and participates rapid GTP-induced vesicular gating swelling. Isolated ZGs exhibit low basal permeability. However, exposure results marked potentiation entry. Treatment...

Coronary artery disease (CAD) has been linked to one of the highest death rates globally. The atherogenic index plasma (AIP) may be an important predictor atherosclerosis and cardiovascular disease, superior standard atherosclerotic lipid profile. This study investigated relationship between AIP obesity indices, blood glucose, profile, nutrient intake status in Korean adult men. included 1292 males aged ≥19 years old who participated Korea National Health Nutrition Examination Survey,...

Abstract N ‐ethylmalemide‐sensitive factor attachment protein receptor (SNARE) has been proposed to play a critical role in the membrane fusion process. The SNARE complex was suggested be minimal machinery. However, there is mounting evidence for major of calcium fusion. Hence, SNARE‐induced focus this study. It revealed that recombinant v‐SNARE and t‐SNARE, reconstituted into separate liposomes, interact bring lipid vesicles close proximity, enabling drive opposing bilayers. Exposure...

Cholera toxin (CT) causes the massive secretory diarrhea associated with epidemic cholera. To induce disease, CT enters cytosol of host cells by co-opting a lipid-based sorting pathway from plasma membrane, through trans-Golgi network (TGN), and into endoplasmic reticulum (ER). In ER, portion is unfolded retro- translocated to cytosol. Here, we established zebrafish as genetic model intoxication examined Derlin flotillin proteins, which are thought be usurped for retro-translocation lipid...

The excessive release of reactive oxygen species (ROS) can result in the development chronic inflammation. mechanisms involved inflammation are various, with endoplasmic reticulum (ER) stress known to be among them. We have previously shown that black ginseng (BG) reduced lipid accumulation and enhanced antioxidant function liver vitro vivo mostly due ginsenoside Rb1, Rg3 Rk1 components. Therefore, this study investigated effect BG on intestines its possible mechanistic pathway through ER...

Fresh vegetables harbor diverse microorganisms on leaf surfaces, yet their viral communities remain unexplored. We investigate the diversity and ecology of phyllosphere viromes six leafy green using virus-like particle (VLP) enrichment shotgun metagenome sequencing. On average, 9.2 × 107 viruses are present per gram tissue. The majority (93.1 ± 6.2%) these taxonomically unclassified. Virome compositions distinct among vegetable types exhibit temporal variations. Virulent phages with...

Type 2 diabetes mellitus (T2DM) is a metabolic disease associated with chronic low-grade inflammation that mainly lifestyles. Exercise and healthy diet are known to be beneficial for adults T2DM in terms of maintaining blood glucose control overall health. We investigated whether combination exercise curcumin supplementation ameliorates diabetes-related cognitive distress by regulating inflammatory response endoplasmic reticulum (ER) stress. This study was performed using male Otsuka...

The intestinal epithelial barrier is the primary and most significant defense against ingested toxins pathogenic bacteria. When epithelium breached, inflammatory response triggered. GWAS data showed that endoplasmic reticulum (ER) stress markers are elevated in Inflammatory Bowel Disease (IBD) patients, which suggests ER regulation might alleviate IBD symptoms. Ferulic acid (FA) a polyphenol abundant plants has antioxidant anti-inflammatory properties, although it unclear whether FA these...

BACKGROUND/OBJECTIVES: Curcumin, a major component of the Curcuma species, contains antioxidant and anti-inflammatory properties.Although it was found to induce apoptosis in cancer cells, functional role curcumin as well its molecular mechanism response, particularly intestinal has been less investigated.The intestine epithelial barrier is first most important location for substrate coming from lumen gut.SUBJECTS/METHODS: We administered treatment human cell lines, T84 Caco-2.We examined...

In recent years, growth hormone deficiency in children has been treated with therapy despite the possible significant side effects. Therefore, it was deemed beneficial to develop functional foods or dietary supplements for safely improving children’s growth. Spirulina platensis is known its high antioxidant, anti-aging, anti-cancer, and immunity-enhancing properties, as well digestibility protein content, but little reported about influence on bone development a normal supply of protein....

The role of diet is gaining attention among the modifiable factors associated with depression; thus, this case-control study examined association between nutrition and depression in young Korean adults. Dietary surveys individuals (n = 39) age- gender-matched controls 76) were conducted using food records frequency questionnaires. Men consumed less mushrooms meat, while women significantly grains (p < 0.05). Overall, group energy nutrients, difference was more pronounced men. male had lower...

BACKGROUND/OBJECTIVES: Inflammatory Bowel Disease (IBD) has rapidly escalated in Asia (including Korea) due to increasing westernized diet patterns subsequent industrialization.Factors associated with endoplasmic reticulum (ER) stress are demonstrated be one of the major causes IBD.This study was conducted investigate effect Lycium barbarum (L.barbarum) on ER stress.MATERIALS/METHODS: Mouse embryonic fibroblast (MEF) cell line and polarized Caco-2 human intestinal epithelial cells were...

Regular exercise as part of one’s lifestyle is well-recognized for its beneficial effect on several diseases such cardiovascular disease and obesity; however, many questions remain unanswered regarding the effects gut environment. This study aimed to investigate impact long-term endurance modulating inflammation endoplasmic reticulum (ER) stress. Fifteen-week-old male Sprague-Dawley (SD) rats were subjected six months treadmill training, while age-matched controls remained sedentary. Results...

Although the prevalence and incidence of inflammatory bowel disease (IBD), a defective immune response gastrointestinal tract, has been increasing in North America Western Europe, recent studies have shown that this is also rapidly Asia. Several searching for functional foods can prevent or reduce IBD symptoms because drug treatments are expensive with complications. Genome-Wide Association Study (GWAS), an observational study genome-wide set genetic variants different individuals, showed...

Abstract Fresh vegetables harbor diverse microorganisms on leaf surfaces, yet their viral communities remain unexplored. We investigated the diversity and ecology of phyllosphere viromes six leafy green using virus-like particle (VLP) enrichment shotgun metagenome sequencing. On average, 9.2 × 10 7 viruses were present per gram tissue. The majority (93.1 ± 6.2%) these taxonomically unclassified. Virome compositions distinct among vegetable types exhibited temporal variations. Virulent phages...

The reported data are related to the article entitled "Ferulic acid maintains self-renewal capacity of embryo stem cells and adipose-derived mesenchymal in high fat diet-induced obese mice" [1]. Ferulic is a natural bioactive compound demonstrated potential serve as self-renewing biomarker an alkaline phosphate assay caused increased Nanog mRNA levels embryonic cells. In these data, we examined another functional aspect ferulic acid, namely effect on cell cycle splenocytes. These were...