Purpose: Physical activity can improve sensorimotor recovery after peripheral nerve injury. We examined the effects of treadmill training (TMT) on axonal regeneration in injured sciatic rat and further investigated cellular molecular events that underlie enhanced regrowth by training. Methods: After crush injury nerves, rats were randomly assigned into either TMT or sedentary groups. Three to 14 d injury, changes protein levels regenerating analyzed Western blotting immunofluorescence...

Schwann cell migration facilitates peripheral nerve regeneration after injury. We have recently found increased activation of Cdc2 kinase in regenerating sciatic nerves. Here we show that phosphorylation caldesmon regulates and regeneration. A robust but transient increase expression was cultured cells prepared from the rats had undergone crush injury for 7 days. These `injury-preconditioned' exhibited enhanced compared with non-preconditioned control treatment cdk inhibitor roscovitine...

Proliferation of Schwann cells in the injured peripheral nerve supports axonal regeneration, and physical training experimental animals has been shown to promote regeneration. Extracellular signal-regulated kinase 1/2 (ERK1/2) activity can mediate neuronal responses lesion signals, but its role non-neuronal area is largely unknown. Here we report that treadmill (TMT) facilitates regeneration via upregulation phospho-ERK1/2 protein levels sciatic nerve. Low-intensity, not high-intensity, TMT...

Obesity is characterized by the induction of skeletal muscle remodeling and mitochondria-mediated apoptosis. Exercise has been reported as a positive regulator However, effects exercise on apoptosis in obese muscles have not clearly elucidated. Four-week-old C57BL/6 mice were randomly assigned into four groups: control (CON), plus (CON + EX), high-fat diet (HFD), HFD groups (HFD EX). After obesity was induced 20 weeks 60% feeding, treadmill performed for 12 weeks. ameliorated obesity-induced...

Recent studies have demonstrated the immunomodulatory effects of heat-killed lactic acid bacteria. The aim this study was to evaluate protective effect Enterococcus faecalis EF-2001 (EF-2001) on a model inflammatory bowel disease (IBD). A total 28 female NC/Nga mice were divided into 4 treatment groups. Controls fed normal commercial diet. In experimental groups, colitis induced by rectal administration dinitrobenzene sulfonic acid. Two groups orally administered 2 and 17 mg/kg EF-2001,...

(1) Background: The amount of physical activity most adults perform is less than the recommended amount, and resulting decrease in strength makes them vulnerable to various diseases. A muscle size due damage caused by disease or aging negatively affects functional strength. Muscle evaluation can yield results that are predictive indicators unexpected disability. In addition, balance ability essential prevent falls injuries daily life maintain activities. It important develop strengthen lower...

The effects of aerobic exercise training on soleus muscle morphology, mitochondria-mediated apoptotic signaling, and atrophy/hypertrophy signaling in ovariectomized rat skeletal were investigated.Female Sprague-Dawley rats divided into control (CON), ovariectomy (OVX), plus (OVX+EX) groups. After ovarian excision, was performed using a treadmill at 20 m/min, 50 min/day, 5 days/week for 12 weeks. Protein levels the (soleus) examined through western immunoblot analysis.The number myocytes...

In the present study, we investigated effect of swimming training and sudden detraining on learning ability spatial memory capability neurogenesis brain-derived neurotrophic factor (BDNF) expression in hippocampus mice. Male ICR mice were randomly assigned into three groups (n= 15 each group): control group, group. The group made to swim (6 days/week, 60 min/day) for 8 weeks. accomplished same program 4 weeks then discontinued exercise results, enhanced short-term memories increased...

Regular exercise as part of one’s lifestyle is well-recognized for its beneficial effect on several diseases such cardiovascular disease and obesity; however, many questions remain unanswered regarding the effects gut environment. This study aimed to investigate impact long-term endurance modulating inflammation endoplasmic reticulum (ER) stress. Fifteen-week-old male Sprague-Dawley (SD) rats were subjected six months treadmill training, while age-matched controls remained sedentary. Results...

This study investigated the effects of resistance exercise on Akt-eNOS, activation antioxidant protein and FOXO1 in aorta F344 rats.[Methods] Male 7 week-old rats were randomly divided into 2 groups: a climbing group (n = 6) sedentary 6).H&E staining western blotting used to analyze rat aortas target proteins.[Results] Resistance training did not significantly affect aortic structure.Phosphorylation AKT eNOS expression MnSOD Ref-1 increased while phosphorylation was decreased compared with...

The aim of this study was to investigate the effects resistance exercise training on hypothalamic GLP-1R levels and its related signaling mechanisms in T2DM. animals were separated into three groups: a non-diabetic control (CON), diabetic (DM), with (DM + EXE) group. group performed ladder climbing (eight repetitions, days per week for 12 weeks). Body weight slightly lower DM EXE than group, but difference between groups not significant. Food intake glucose significantly blood insulin...

The purpose of this study was to investigate the expression lipogenesis- and lipolysis-related genes proteins in skeletal muscles after 12 weeks resistance training. Sprague-Dawley rats (n=12) were randomly divided into control (resting) training groups. A tower-climbing exercise, which climbed top their cage with a weight applied tails, used for After weeks, from group had lower body weights (411.66±14.71 g vs. 478.33±24.63 control), there no significant difference between two groups...

Intracerebral hemorrhage (ICH) is a major cause of death and disability in the elderly. In present study, we examined age-dependence effect treadmill exercise on intrastriatal hemorrhage-induced neuronal cell rats. Young (8 weeks old) old (64 Sprague-Dawley male rats were used study. Intrastriatal was induced by injection 0.2 U collagenase (1 μL volume) into striatum using stereotaxic instrument. The groups forced to run for 30 min daily 7 days. Lesion size determined Nissl staining....

BACKGROUND: Studies on antioxidant enzyme activity and apoptosis related protein expression associated with diabetes are mainly limited to aerobic exercise. Since the effectiveness efficiency of resistance has recently emerged, it is necessary investigate effects regul ar exercise these factors. OBJECTIVE: The purpose this study was enzymes activities in hippocampus diabetic rats. METHODS: Twenty-one male rats were divided into 3 groups: LETO (control group), OLETF (diabetes group) + EX...

Review 서 론 비알코올성 지방간 질환(non-alcoholic fatty liver disease, NAFLD)은 과도한 알코올 섭취, 바이러스 감염 및 기타 간질환 등의 병적 소견이 없이 간 조직의 중성지방(triglyceride) 함량이 전체 무 게의 5% 이상인 상태를 의미하는 대사 질환(metabolic disease)의 일 종으로써 지방간은 조직에 중성지방이 비정상적으로 누적된 단순 지방간(simple steatosis), 염증(inflammation)을 동반하는 지방간염(steatohepatitis), 염증과 더불어 세포 괴사(apoptosis)를 간경변(cirrhosis)에 이르기 까지 병리학 적 진행 상태에 따라 세분화하며, 치료하지 않고 방치할 경우 궁극적 으로 간암으로까지 진행되어 조기 사망을 일으킬 수 있는 질환이다. 1 당뇨(diabetes), 고혈압(hypertension), 심혈관 질환(cardiovascular disease) 등 대사질환의...

The aim of this study was to investigate the effect 12 wks plyometric training on motor nerve conduction velocity and isokinetic muscular functions in boys while attending community-based soccer club. Fourteen trained physically active male were divided into control(n=7; age 11.34 ± 1.82 years) experimental groups(n=7; 11.23 2.21 years). groups followed a twice-weekly, 12-week program, control participated their normal lessons. Motor obtained from posterior tibial using Viking IV. Using an...

This study aimed to determine the effect of 6 weeks plyometric training (PT) on agility, vertical jump and isokinetic leg strength in korea ROTC (Reserve Officers’ Training Corps) cadets. Subjects were divided into two groups, a (N=12) control group (N=12). The performed eight program((i.e., jumping, hopping, sprint, bounding) did not perform any techniques. Plyometric twice week for weeks. A pre post test was conducted measure alility, jump(VJ), strength(knee extention, knee flexion). After...

당뇨병은 만성적 대사질환으로 말초뿐만 아니라 중추신경계에서도 다양한 합병증을 유발시키는 것으로 알려져 있다. 특히, 당뇨환자는 인지기능의 손상으로 인해 치매 유병율이 높은 보고되고 규칙적인 운동은 당뇨병의 이차 예방하기 위한 치료적 방법으로 흔히 권장된다. 이에 본 연구는 당뇨흰쥐를 대상으로 트레드밀 운동이 기억력과 해마 BDNF 발현에 미치는 효과를 조사하였다. SD계열 흰쥐를 실험동물로 하여 STZ (50 mg/kg) 투여로 유발시킨 8주간 주 5회 30분씩 트레드밀에서 달리도록 하였다. 운동프로그램 종료 후, Morris water maze로 기억력을 측정하고, 해마조직을 적출하여 Western으로 brain-derived neurotrophic factor (BDNF) 발현을 정량화하였다. 연구결과 8주간의 당뇨는 선행연구과 유사하게 기억력 손상과 함께 조직의 유의하게 감소시키는 나타났다. 하지만 당뇨흰쥐에서 향상시키는 이러한 결과는 당뇨동물에서 발현의 증가를 통해...

PURPOSE: The purpose of this study was to investigate the effects 5 weeks basic military training on physical fitness and blood biochemical factors in obese recruits.METHODS: Forty-eight male recruits (20-25 years age) were randomly assigned Control group Exercise group. Both groups completed training. additionally performed a resistance exercise twice daily morning afternoon (1-3 sets, 3 days per week) power walking (60-80% HRmax, 30 minutes) four times weekly. Four body composition...

The present study aimed to examine the anti-inflammatory effects and potential mechanism of action Artemisia asiatica Nakai (A. Nakai) extract in activated murine macrophages. A. showed dose-dependent suppression lipopolysaccharide (LPS)-induced nitric oxide, inducible oxide synthase, cyclooxygenase-2 activity. It also inhibition nuclear factor-κB (NF-κB) translocation from cytosol nucleus as an inhibitor NF-κB-alpha phosphorylation. extract's inhibitory were found be mediated through NF-κB...

Current studies investigating methods to help reduce muscle injury after exercise have the limitation that they not been conducted in obese populations.Therefore, their effect on people is questionable.These issues need be considered via well-designed future.