A5083419255- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- RNA and protein synthesis mechanisms
- Nerve injury and regeneration
- Cholinesterase and Neurodegenerative Diseases
- MicroRNA in disease regulation
- Scoliosis diagnosis and treatment
- Electrocatalysts for Energy Conversion
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Asian Culture and Media Studies
- Bacteriophages and microbial interactions
- 3D Printing in Biomedical Research
- Biosensors and Analytical Detection
- Neonatal and fetal brain pathology
- Spinal Fractures and Fixation Techniques
- Metal-Catalyzed Oxygenation Mechanisms
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory mediators and NSAID effects
- Bioactive Compounds and Antitumor Agents
- Extracellular vesicles in disease
- RNA modifications and cancer
University of Seoul
2016-2024
Ulsan College
2024
University of Ulsan
2012-2024
Seoul National University of Science and Technology
2024
Ajou University
2024
Dong-A Pharmaceutical (South Korea)
2016-2024
Asan Medical Center
2016-2024
Dong-A ST (South Korea)
2023-2024
Chungbuk National University
2011-2023
Korea Electronics Technology Institute
2022
DNA-templated metallization has emerged as an efficient strategy for creating nanoscale-metal DNA hybrid structures with a desirable conformation and function. Despite the potential of DNA–metal hybrids, their use combinatory therapeutic agents rarely been examined. Herein, we present simple approach fabricating multipurpose superstructure that serves photoimmunotherapy agent. Specifically, adsorb locally concentrate Au ions onto superstructures through induced local reduction, resulting in...
Abstract Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting in profound neurobehavioral cognitive dysfunction from decreased acetylcholine biosynthesis reduced secretion growth neurotrophic factors. Human adipose tissue‐derived mesenchymal stem cells (ADMSCs) were intravenously (1 × 10 6 cells) or intracerebroventricularly (4 5 transplanted into brains 18‐month‐old mice once four times at 2‐week intervals. Transplantation ADMSCs improved both...
The anti-inflammatory effects of fuciodan and Cistanche tubulosa (CT) extract were investigated in vitro macrophage culture system vivo carrageenan-induced air pouch inflammation model. CT inhibited nitric oxide production from activated RAW 264.7 cells, while fucoidan was inactive. In model, vascular exudation increased prostaglandin E2 concentrations the exudates synergistically suppressed by co-administration or extract. Moreover, tissue substantially attenuated combinational therapy....
Abstract Background: The aryl hydrocarbon receptor plays a pivotal role in regulating cancer metabolism and is activated across various immune cell types. Its activation fosters suppression by enhancing the functions of regulatory cells within tumor microenvironment. Methods: LysMCre or ItgaxCre/AhRLoxP transgenic (Tg) mice were generated to investigate AhR knockout myeloid lineage dendritic specifically. antitumor effects evaluated using engrafted TC1 lung cells. Results: To evaluate impact...
Hypochlorous acid (HOCl) is generated in the immune system to kill microorganisms. In Escherichia coli , a hypochlorite-specific transcription regulator, HypT, has been characterized. HypT belongs LysR-type transcriptional regulator (LTTR) family that contains DNA-binding domain (DBD) and regulatory (RD). Here, we identified hypT gene from Salmonella enterica serovar Typhimurium determined crystal structures of full-length protein RD. The structure reveals type tetrameric assembly LTTR...
Abstract Aging brings about the progressive decline in cognitive function and physical activity, along with losses of stem cell population function. Although transplantation muscle-derived stem/progenitor cells extended health span life progeria mice, such effects normal animals were not confirmed. Human amniotic membrane-derived mesenchymal (AMMSCs) or adipose tissue-derived (ADMSCs) (1 × 106 per rat) intravenously transplanted to 10-month-old male F344 rats once a month throughout their...
As ribonucleic acid (RNA) nanotechnology has advanced, it been applied widely in RNA‐based therapeutics. Among the range of approaches, enzymatically synthesized RNA structures for inducing interference cancer cells have potential silencing genes a target‐specific manner. On other hand, efficiency gene needs to be improved utilize system RNAi This paper introduces new approach efficient generation siRNA from bubbled cargo (BRC). The presence bubbles between avoid nonfunctional short dsRNAs...
The demonstrated strategy is useful for constructing high-performance catalytic superstructures using nanoframes as building blocks, leading to the carbon-free Pt nanoparticle catalysts.
Periventricular leukomalacia, specifically characterized as white matter injury, in neonates is strongly associated with the damage of pre-myelinating oligodendrocytes. Clinical data suggest that hypoxia-ischemia during delivery and intrauterine or neonatal infection-inflammation are important factors etiology periventricular leukomalacia including cerebral palsy, a serious case exhibiting neurobehavioral deficits leukomalacia. In order to explore pathophysiological mechanisms injury better...
The number of traffic accident by drowsiness has the highest percentage every year. Recently, detection is actively researched. most practical approach to drowsy driving generally known as image processing techniques which estimate using eye-blink pattern. However, technique can't detect with eyes open. This paper proposes method open EEG-based power spectrum analysis. Subjects are selected that based on ESS(Epworth Sleepiness Scale). In experiments, all electronic devices turned off reduce...
Improving cell reprogramming methods is vital to regenerative medicine efforts. This review discusses advances in using biomaterial based approaches.
As emerging evidence supports the immune stimulating capability of CpG oligodeoxynucleotides (ODN), CpG-based adjuvants have been widely used. For efficient induction responses, current issues affecting use nucleic acid-based adjuvants, e.g. stability in physiological conditions, delivery to cells, and successful release within phagolysosome, should be addressed. Here, we present DNA microparticles (DNA-MPs) fabricated by complementary rolling circle amplification (cRCA) as for enhancing...
This paper reports a methodology for synthesizing and ordering gold nanoframes into three-dimensional (3D) arrays with controlled thickness, leading to homogeneous plasmonic superstructures, which quantitative analysis via surface-enhanced Raman spectroscopy (SERS) has been successfully demonstrated. Because this preparation method allows systematic control of nanoframe film thickness the resulting 3D superstructure, exhibits unique nanoporous network hot-spots, detection limits down 10-18...
RNA membrane-based microneedle coating system for the facile fabrication of tailor-made microneedles transdermal drug delivery.
Improving the effects of human adipose tissue-derived mesenchymal stem cells (ASCs) on demyelination and neurobehavioral function was investigated in an experimental model neonatal hypoxic-ischemic encephalopathy (HIE). Seven-day-old male rats were subjected to hypoxia-ischemia-lipopolysaccharide intracerebroventricularly transplanted with ASCs (4 × 10(5) cells/rat) once at postnatal day 10 (PND10) or repeatedly PND10, 17, 27, 37. Neurobehavioral abnormalities (at PND20, 30, 40) cognitive...
Perovskite solar cells (PSCs) have attracted considerable attention due to their excellent photovoltaic properties, but stability issues prevented widespread application. PSCs must be protected by encapsulation extend lifetime. Here, we show that perhydropolysilazane (PHPS)-based multilayered improves the lifetime of PSCs. The were encapsulated converting PHPS into silica under vacuum ultraviolet (UV) irradiation. PHPS-based multilayer method achieved a sandwich structure PHPS/poly(ethylene...
The anti-obesity activities of Rapha diet® preparation containing silkworm pupa peptide, Garcinia cambogia, white bean extract, mango raspberry cocoa and green tea extract were investigated in mice with dietary obesity. Male C57BL/6 fed a high-fat diet (HFD) 3% for 8 weeks, blood tissue parameters obesity analyzed. HFD markedly enhanced body weight gain by increasing the weights epididymal, perirenal, mesenteric adipose tissues. increased induced was significantly reduced feeding...
The effects of polarized-light therapy (PLT) on high-cholesterol diet (HCD)-induced hypercholesterolemia and atherosclerosis were investigated in comparison with that lovastatin rabbits. Hypercholesterolemia was induced by feeding male New Zealand white rabbits 1% cholesterol for 2 weeks maintained 0.5% 6 weeks, followed normal recovery. Lovastatin (0.002% diet) or daily 5-min 20-min PLT the outside surface ears started after induction hypercholesterolemia. Hypercholesterolemic exhibited...
The neuroprotective effects of a butanol fraction white rose petal extract (WRPE-BF) were investigated in middle cerebral artery occlusion (MCAO) model. Seven week-old male rats orally administered WRPE-BF for 2 weeks and subjected to MCAO h, followed by reperfusion. Twenty-four h later, MCAO-induced behavioral dysfunctions markedly improved dose-dependent manner pretreatment with WRPE-BF. Moreover, higher dose not only decreased infarction area but also effectively reduced astrogliosis....
Since multiple sclerosis (MS) is featured with widespread demyelination caused by autoimmune response, we investigated the recovery effects of F3.olig2 progenitors, established transducing human neural stem cells (F3 NSCs) Olig2 transcription factor, in myelin oligodendrocyte glycoprotein‐ (MOG‐) induced experimental encephalomyelitis (EAE) model mice. Six days after EAE induction, F3 or (1 × 10 6 /mouse) were intravenously transplanted. MOG‐injected mice displayed severe neurobehavioral...