A5113193335- Tryptophan and brain disorders
- Telemedicine and Telehealth Implementation
- Morinda citrifolia extract uses
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Cancer-related gene regulation
- Psychosocial Factors Impacting Youth
- Photosynthetic Processes and Mechanisms
- Microbial Metabolites in Food Biotechnology
- Lipid metabolism and biosynthesis
- Asthma and respiratory diseases
- Seed and Plant Biochemistry
- Educational Systems and Policies
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
Yonsei University
2022-2025
Sungkyunkwan University
2020
Chungnam National University
2016
Background/Objectives: Access to healthcare in medically underserved areas remains a significant challenge South Korea due the concentration of resources metropolitan regions. Telemedicine offers promising approach mitigating this issue, yet its cost-effectiveness these settings underexplored. This study aims conduct cost-minimization analysis comparing teleconsultation and in-person care for chronic diseases, dementia, rehabilitation areas. Methods: In accordance with CHEERS 2022...
Abstract This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The content (TBS) is five times higher than that found common (CBS) as evident high-performance liquid chromatography analysis. Administration either or TBS ethanolic extract to mice decreased serum glucose level significantly. Rutin down-regulated expression levels protein-tyrosine phosphatase 1B; it negative regulator insulin pathway, both transcriptionally and...
Abstract Background: The aryl hydrocarbon receptor plays a pivotal role in regulating cancer metabolism and is activated across various immune cell types. Its activation fosters suppression by enhancing the functions of regulatory cells within tumor microenvironment. Methods: LysMCre or ItgaxCre/AhRLoxP transgenic (Tg) mice were generated to investigate AhR knockout myeloid lineage dendritic specifically. antitumor effects evaluated using engrafted TC1 lung cells. Results: To evaluate impact...
Among cancer cells, indoleamine 2, 3-dioxygenase1 (IDO1) activity has been implicated in improving the proliferation and growth of cells suppressing immune cell activity. IDO1 is also responsible for catabolism tryptophan to kynurenine. Depletion an increase kynurenine exert important immunosuppressive functions by activating regulatory T CD8 + natural killer (NK) cells. In this study, we compared anti-tumor effects YH29407, best-in-class inhibitor with improved pharmacodynamics...
Abstract Background Live biotherapeutic products (LBPs) are known to enhance immune responses through the GUT-TME axis. Here, we investigate GUT-TME-related cell profiling and signals associated with anti-cancer effects of CJRB-101. Methods Tumors from NSCLC patients (anti-PD-1 refractory) were transplanted in Hu-CD34-NSG establish humanized patient-derived xenograft (PDX) models. CJRB-101 was administered at 1x109 CFU (p.o., BID) or combination anti-PD-1 (10 mpk, i.p., BIW). TME analyzed...