A5016970576- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Myasthenia Gravis and Thymoma
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Metastasis and carcinoma case studies
- Medical Imaging and Pathology Studies
- Ferroptosis and cancer prognosis
- Trauma Management and Diagnosis
- Respiratory Support and Mechanisms
- Head and Neck Cancer Studies
- Immune cells in cancer
- Cancer Cells and Metastasis
Sungkyunkwan University
2016-2025
Samsung Medical Center
2016-2025
Johns Hopkins University
2025
Palmetto Hematology Oncology
2023
Asan Medical Center
2022
Yonsei University
2021
Kolon Life Science (South Korea)
2017-2020
Ministry of Science ICT and Future Planning
2015
WinnMed
2014
Mayo Clinic
2014
Abstract Advanced metastatic cancer poses utmost clinical challenges and may present molecular cellular features distinct from an early-stage cancer. Herein, we single-cell transcriptome profiling of lung adenocarcinoma, the most prevalent histological type diagnosed at stage IV in over 40% all cases. From 208,506 cells populating normal tissues or early to 44 patients, identify a cell subtype deviating differentiation trajectory dominating stage. In stages, stromal immune dynamics reveal...
The aim of this study was to determine the distribution known oncogenic driver mutations in female never-smoker Asian patients with lung adenocarcinoma. We analyzed 214 across 26 cancer-associated genes and three fusion using MassARRAY LungCarta Panel ALK, ROS1, RET assays 198 consecutively resected adenocarcinomas from females at a single institution. EGFR mutation, which most frequent gene detected 124 (63%) cases. Mutation KRAS, PIK3CA, ERBB2, BRAF, genesoccurred 7%, 4%, 2.5%, 1.5%, 1%,...
Quantitative imaging using radiomics can capture distinct phenotypic differences between tumors and may have predictive power for certain phenotypes according to specific genetic mutations. We aimed identify the clinicoradiologic predictors of with ALK (anaplastic lymphoma kinase), ROS1 (c-ros oncogene 1), or RET (rearranged during transfection) fusions in patients lung adenocarcinoma.A total 539 pathologically confirmed adenocarcinomas were included this retrospective study. The baseline...
Recent studies have reported the predictive and prognostic value of novel transcriptional factor-based molecular subtypes in small-cell lung cancer (SCLC). We conducted an in-depth analysis pairing multi-omics data with immunohistochemistry (IHC) to elucidate underlying characteristics associated differences clinical outcomes between subtypes.
In patients with non–small cell lung cancer, obesity was associated improved overall survival after curative resection, particularly when CT-assessed skeletal muscle mass and radiodensity were preserved.
OBJECTIVESAlthough the standard video-assisted thoracoscopic surgery (VATS) approach is generally performed through two to four incisions, uniportal VATS pulmonary resection has recently been reported be a promising, less invasive alternative. To evaluate adequacy of lobectomy as an alternative conventional in lung cancer, we analysed and compared outcomes lobectomies.
Outcomes of antibiotic treatment for lung disease caused by nontuberculous mycobacteria (NTM) are unsatisfactory. The role adjunctive surgery in the NTM is still unclear.We conducted a retrospective review 70 patients who underwent pulmonary resection from March 2007 to February 2013. All received recommended before and after surgery.A total 74 operations. median age was 50 years. Of patients, 45 (64%) had Mycobacterium avium complex infection (24 M. intracellulare 21 avium) 23 (33%)...
The prevalence of lung cancer has been increasing in healthy elderly patients with preserved pulmonary function and without underlying diseases. We aimed to determine the risk factors for postoperative complications (PPCs) non-small cell (NSCLC) select optimal candidates surgical resection this subpopulation. included 488 older than 70 years normal spirometry results who underwent curative NSCLC (stage IA-IIB) between 2012 2016. median (interquartile range) age our cohort was 73 (71–76)...
Lung cancer diagnostic guidelines advocate for invasive mediastinal nodal staging (IMNS), but the survival benefits of this approach in patients with non-small cell lung (NSCLC) without radiologic evidence lymph node metastasis (rN0) remain uncertain. We aimed to investigate impact IMNS rN0 NSCLC by comparing long-term between who underwent and those did not (non-IMNS).
Guidelines recommend invasive mediastinal staging for centrally located tumours, even in radiological N0 nonsmall cell lung cancer (NSCLC). However, there is no uniform definition of a central tumour that more predictive occult metastasis.A total 1337 consecutive patients with disease underwent staging. Tumours were categorised into and peripheral by seven different definitions.About 7% (93 out 1337) had N2 disease, they significantly larger size solid tumours on computed tomography. After...
Abstract Detecting aberrant cell-free DNA (cfDNA) methylation is a promising strategy for lung cancer diagnosis. In this study, our aim to identify markers distinguish patients with from healthy individuals. Additionally, we sought develop deep learning model incorporating cfDNA and fragment size profiles. To achieve this, utilized data collected The Cancer Genome Atlas Gene Expression Omnibus databases. Then generated methylated immunoprecipitation sequencing genome-wide Enzymatic...
Understanding the patterns of lymph node (LN) metastases in esophageal squamous cell carcinoma (ESCC) is important for accurate staging and defining extent lymphadenectomy. This study clarified LN ESCC using data mining techniques. 1181 patients with who underwent upfront esophagectomy were analyzed. Network analysis association rule (ARM) techniques employed to visualize quantify according T stage (T1 vs. T2–4) primary lesion location. plots depicted relationship between lesions metastatic...