A5054852822- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Esophageal Cancer Research and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cerebrovascular and Carotid Artery Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Chromatin Remodeling and Cancer
- Myasthenia Gravis and Thymoma
- Liver Disease Diagnosis and Treatment
- Coronary Artery Anomalies
- Esophageal and GI Pathology
- Health, Environment, Cognitive Aging
- Chronic Lymphocytic Leukemia Research
- AI in cancer detection
- Ultrasound and Hyperthermia Applications
- Pleural and Pulmonary Diseases
- HIV/AIDS drug development and treatment
- Cardiac Structural Anomalies and Repair
- Wound Healing and Treatments
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Microbial Natural Products and Biosynthesis
- MRI in cancer diagnosis
- Multiple Myeloma Research and Treatments
Samsung Medical Center
2017-2025
Ulsan National Institute of Science and Technology
2025
Sungkyunkwan University
2017-2024
Pohang University of Science and Technology
2024
Military Manpower Administration
2022
Yonsei University
1997-2021
Asan Medical Center
2020-2021
University of Ulsan
2020
Ulsan College
2020
Molina Center for Energy and the Environment
2019
Guidelines recommend invasive mediastinal staging for centrally located tumours, even in radiological N0 nonsmall cell lung cancer (NSCLC). However, there is no uniform definition of a central tumour that more predictive occult metastasis.A total 1337 consecutive patients with disease underwent staging. Tumours were categorised into and peripheral by seven different definitions.About 7% (93 out 1337) had N2 disease, they significantly larger size solid tumours on computed tomography. After...
Enrichment of tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment (TME) is a reliable biomarker immune checkpoint inhibitors (ICI) non-small cell lung cancer (NSCLC). Phenotyping through computed tomography (CT) radiomics has overcome limitations tissue-based assessment, including for TIL analysis. Here, we assess enrichment objectively using an artificial intelligence-powered analysis hematoxylin and eosin (H&E) image analyze its association with quantitative radiomic...
Lung cancer remains one of the most lethal cancers globally, with nonsmall cell lung (NSCLC) representing predominant subtype. Despite significant advancements in targeted therapies, overcoming therapeutic resistance NSCLC a challenge, particularly cases resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). Here, we developed target-specific, protein nanoparticles using Aquifex aeolicus...
e13628 Background: Despite the wide availability and cost-effectiveness of chest X-rays (CXRs), their potential as a biomarker for immune checkpoint inhibitor (ICI) response in non-small cell lung cancer (NSCLC) remains largely unexplored. We developed validated novel deep learning model that predicts ICI from single pre-treatment CXR, independent histopathologic biomarkers including PD-L1 expression phenotype. Methods: A retrospective dataset 2,905 NSCLC patients at Samsung Medical Center...
Abstract This study aimed to evaluate the frequency of nodal metastases and disclose diagnostic performance endoscopic ultrasonography (EUS) PET/CT in T N staging surgically resected early‐stage esophageal squamous cell carcinomas (eSCCs). Institutional review board approved this retrospective with waiver informed consent for reviewing medical record. We included 435 patients an early T‐stage (Tis or T1a [≤T1a], T1b T2) eSCC . The rates metastatic lymphadenopathy were calculated. Then, EUS...
The objective of our study was to investigate histopathology features, imaging and prognoses surgically resected pure small cell lung carcinomas (SCLCs) combined SCLCs.Forty-one patients with a SCLC or underwent preoperative chest CT 18F-FDG PET/CT subsequent surgical resection. clinicopathologic findings were noted by reviewing the electronic medical records. features individual tumors analyzed on scans. Each tumor classified as being located centrally (at in segmental bronchus proximal...
Awareness of volume doubling times (VDTs) different thymic epithelial tumors (TETs), including low- and high-grade thymomas carcinomas, is important for their management. The purpose this study was to evaluate the VDTs incidentally found TETs using 3D volumetry (3D-VDT) longest diameter (LD-VDT).This retrospective included 50 patients (30 men, 20 women) who had histologically proven underwent at least two serial CT studies greater than 2-month intervals. were classified into World Health...
We aimed to report patients' survival after surgical resection of eSCC and ascertain the clinical, imaging, pathological factors related patient prognosis. This retrospective study included 435 patients with <stage T2 (median follow-up period, 49.3 months). A total 103 (23.7%) died, 89 (20.5%) experienced recurrence during follow-up. The maximum standardized uptake value (SUVmax) on positron emission tomography (PET)/computed (CT) primary tumor was significantly correlated length, nodal...
Abstract Background: Previously, AI-powered spatial tumor-infiltrating lymphocyte analysis in H&E whole-slide image (WSI) showed promising performance predicting ICI outcomes. However, there were several innate limitations of tissue analysis, including the time lag between biopsy and actual administration, during which tumor microenvironment (TME) has changed, analyzing a part single would not fully assess immunogenicity multiple metastatic tumors. To overcome challenges, we developed...
Ectopic sebaceous glands are found very rarely in the esophagus; heretofore, several cases have been reported. The gland is originally a source of an endodermal origin; however, there controversies regarding whether origin esophageal ectopic ectodermal or endodermal. esophagus usually do not cause symptoms; thus, they often incidentally on endoscopy for routine health screening. Endoscopic findings characterized by single multiple yellow patches nodular lesions various sizes, sometimes with...
Objective To evaluate the effect of perfluorobutane microbubbles (Sonazoid®, GE Healthcare) on steam popping during radiofrequency (RF) ablation for treating hepatocellular carcinoma (HCC), and to assess whether affects treatment outcomes. Materials methods The institutional review board approved this retrospective study, which included 90 consecutive patients with single HCC, who received percutaneous RF as first-line treatment. were divided into two groups, based presence or absence...
Focal interstitial fibrosis (FIF) manifesting as a persistent part-solid nodule (PSN) has been mistakenly treated surgically due to similar imaging features invasive adenocarcinoma (ADC). The purpose of this study was observe predictive correlated with FIF through CT morphologic analysis.
Background: Ring finger protein 213 (RNF213) vasculopathy is a non-atherosclerotic occlusive disease in intracranial arteries that frequently occurs the Asian population. Nevertheless, it remains unclear whether increases risk of developing Moyamoya and stroke recurrence compared with isolated arterial without RNF213 mutation.Methods: This retrospective case–control study analysed patients who visited Asan Medical Center steno-occlusive lesions on M1 segment middle cerebral artery terminal...
8536 Background: Immune checkpoint inhibitors (ICI) are an integral part of the treatment for advanced or metastatic non-small cell lung cancer (NSCLC). Chest CT and pathology data is gathered in routine clinical practice, each modality provides complementary information. Tumor microenvironment spatially heterogeneous temporally dynamic. images provide macro-level characteristics multiple tumors, tissue-based histopathologic biomarkers analyze a single representative tumor in-depth. We...
2663 Background: Enrichment of tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment (TME) is a reliable biomarker immune checkpoint inhibitors (ICI) non-small cell lung cancer (NSCLC). Phenotyping through CT radiomics has overcome limitations tissue-based assessment, including for TIL analysis. Here, we objectively assess enrichment using an artificial intelligence-powered H&E analyzer, Lunit SCOPE IO, and analyze its association with advanced quantitative imaging features...
Background: International Myeloma Working Group (IMWG) evaluates treatment response based on plasma cell percentage in bone marrow, amount of light chain, concentration monoclonal protein assessed by immunofixation and/or electrophoresis. In 2016, IMWG newly adopted next‐generation flow (NGF) as an additional assessment tool for the detection MRD, but sequencing (NGS) IgH rearrangement was not included. Aims: present study, we conducted NGS V(D)J rearrangements multiple myeloma (MM) patients...