A5010898771- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Treatments and Mutations
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Viral-associated cancers and disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Eosinophilic Esophagitis
- Intraocular Surgery and Lenses
- Thyroid Cancer Diagnosis and Treatment
- Bipolar Disorder and Treatment
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Connexins and lens biology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Attention Deficit Hyperactivity Disorder
- Colorectal Cancer Screening and Detection
Samsung Medical Center
2014-2022
Sungkyunkwan University
2014-2021
Ministry of Science ICT and Future Planning
2015
Quantitative imaging using radiomics can capture distinct phenotypic differences between tumors and may have predictive power for certain phenotypes according to specific genetic mutations. We aimed identify the clinicoradiologic predictors of with ALK (anaplastic lymphoma kinase), ROS1 (c-ros oncogene 1), or RET (rearranged during transfection) fusions in patients lung adenocarcinoma.A total 539 pathologically confirmed adenocarcinomas were included this retrospective study. The baseline...
We aimed to compare the efficacy of combined immunosuppression in terms mucosal healing paediatric patients with moderate-to-severe luminal Crohn's disease receiving infliximab according either an 'escalated immunosuppression' or 'early strategy. In this prospective observational study, was evaluated at weeks 14 and 54 from baseline infusion. Comparison performed between escalated group [group A] early B]. Factors associated infusion were also investigated. Seventy-six initiated concomitant...
Although the obesity paradox is a topic of immense interest for oncologists and epidemiologists, mechanism underlying this unexpected benefit poorly understood. We explored prognostic value its association with skeletal muscle mass.This retrospective study evaluated data patients who underwent surgical excision lung adenocarcinoma between January 2011 December 2015. Body mass index was categorized according to criteria Asia-Pacific classification. Cross-sectional areas muscle, subcutaneous...
// Jung Min Bae 1, * , Ji Yun Jeong 2, Ho Lee 1 Insuk Sohn 3 Hye Seung Kim Ye Son O Kwon 4 Joon Young Choi 5 Kyung Soo Mog Shim 6 Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School Medicine, Seoul 135-710, Korea 2 Pathology, Kyungpook National Daegu 702-210, Biostatistics Clinical Epidemiology Division Respiratory Critical Medicine the Internal Nuclear Thoracic Cardiovascular Surgery, Gangnam-gu, These authors contributed equally to...
Currently, no recurrence or mortality risk systems consider molecular testing when predicting thyroid cancer outcomes.We developed an integrative prognostic system that incorporates telomerase reverse transcription (TERT) promoter mutations into the recently proposed reclassification after initial therapy [dynamic stratification (DRS)] to better categorize and predict outcomes.A total of 357 differentiated (DTC) patients without distant metastasis were enrolled. Among with mutated TERT...
The aim of the study was to develop a reliable and easy-to-use risk-scoring system (RSS) predict lymph-node metastasis (LNM) determine feasibility endoscopic submucosal dissection for mucosa-confined signet ring cell carcinomas (SRCs).Fewer LNM better survival rates have been reported early gastric SRCs compared with other undifferentiated cancers (EGCs).Data from 1544 patients were reviewed. Stepwise logistic regression analysis determined independent predictors LNM. Risk scores based on...
Abstract Acid suppressants such as histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) are effective in preventing gastrointestinal (GI) bleeding nonsteroidal anti-inflammatory drugs (NSAIDs) users. Despite widespread acid suppressant use, there remain concerns about several potential risks of long-term use. Therefore, we investigated whether gastroprotective agents (GPAs) other than suppression therapy NSAID-related GI injury. To this end, studied 9,133 patients with...
Follicular thyroid carcinoma (FTC) has different clinicopathological characteristics than papillary carcinoma. However, there are no independent systems to predict cancer-specific survival (CSS) in FTC. Telomerase reverse transcriptase (TERT) promoter mutations associated with tumor aggressiveness. Thus, it could be a potential prognostic marker. The aim of this study was refine the CSS risk prediction using TERT combination fourth edition World Health Organization (WHO 2017) morphological...
In this era of personalized medicine, there is an expanded demand for advanced imaging biomarkers that reflect the biology whole tumor. Therefore, we investigated a large number computed tomography-derived radiomics features along with demographics and pathology-related variables in patients lung adenocarcinoma, correlating them overall survival.Three hundred thirty-nine who underwent operation adenocarcinoma were included. Analysis was performed using 161 features, demographic, pathologic...
This study aimed to investigate the performance of a deep learning-based survival-prediction model, which predicts overall survival (OS) time glioblastoma patients who have received surgery followed by concurrent chemoradiotherapy (CCRT). The medical records had and CCRT between January 2011 December 2017 were retrospectively reviewed. Based on our inclusion criteria, 118 selected semi-randomly allocated training test datasets (3:1 ratio, respectively). A convolutional neural network-based...
To identify risk factors for the development of presenile nuclear cataract in health screening test.The cross sectional study included a total 532 eyes 266 participants aged 30 to 49 years Samsung Medical Center from February 2013 April 2015. Presence was defined when log MAR visual acuity with correction greater than or equal 0.2 and one more following were met: Pentacam Nuclear Staging (PNS) grading score ≥ 1, average value density 15%, maximum 30%. Possible obtained blood tests...
Abstract Imaging features can be useful for identifying distinct genomic differences and have predictive power certain phenotypes attributed to mutations. We aimed identify imaging biomarkers that underpin alterations clinical outcomes in lung squamous cell carcinoma (SQCC) using a radiomics approach. In 57 patients with SQCC who underwent preoperative computed tomography (CT) whole-exome DNA sequencing, 63 quantitative were extracted from CT 73 clinicoradiological including classified into...
Current guidelines recommend definitive radiotherapy for patients with medically inoperable early-stage non-small cell lung cancer (NSCLC). However, the impact of underlying pulmonary diseases on survival in those remains unclear.We retrospectively reviewed medical records 234 stage I-II NSCLC treated alone at Samsung Medical Center between January 2010 and October 2017. We compared outcomes according to presence diseases, including chronic obstructive disease (COPD), combined fibrosis...
Little is known about the risk factors associated with serrated polyps, because early studies, which occurred before new World Health Organization classification was introduced, included mixtures of polyps. This study aimed to evaluate presence sessile adenomas (SSAs) and traditional (TSAs) using big data analytics.Using a case-control design, we evaluated SSAs TSAs. Subjects who underwent colonoscopies from 2002 2012 as part comprehensive health screening programs undertaken at Samsung...
Hepatocellular Carcinoma Risk of Compensated CirrhosisPatients with Elevated HBV DNA Levels according to Serum Aminotransferase Sometimes, hepatitis B virus (HBV)-related cirrhotic patients normal aminotransferase levels are closely followed-up for the elevation instead prompt antiviral therapy (AVT).We analyzed long-term hepatocellular carcinoma (HCC) risk in a retrospective cohort 1,468 treatmentnaïve, HBV-related, compensated cirrhosis elevated (≥ 2,000 IU/mL).Based on levels, were...
Antiviral therapy is a key component in the management of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients. However, whether potent drug entecavir more effective than less drug, such as lamivudine, HBV-related HCC not clear.A retrospective cohort 451 newly diagnosed, patients without antiviral at diagnosis, who started with either (n=249) or lamivudine (n=202), were enrolled.The median survival was longer for group group, and use (vs entecavir) an independent factor...
Genetic variation of the serotonin transporter gene (SLC6A4) has been suggested as potential mediator for antidepressant response in patients with depression. This study aimed to determine whether DNA methylation SLC6A4 changes after treatment and it affects Overall, 221 Korean depression completed 6 weeks selective reuptake inhibitor (SSRI) monotherapy. was extracted from venous blood pre- post-treatment, analyzed using polymerase chain reaction. We used Wilcoxon's signed-rank test verify...
A right liver graft with multiple hepatic artery (HA) stumps can be found in approximately 5% of living donor transplantation (LDLT) using a lobe graft. From January 2000 to June 2014, 1149 patients underwent LDLT procedures. Thirty HA and 149 single stump were enrolled. These divided into 3 groups: (group 1, n = 149), HAs total reconstruction 2, 19), selective partial 3, 11). Selective was performed only when pulsatile back-bleeding confirmed after larger sufficient intrahepatic arterial...