A5037009228- Breast Cancer Treatment Studies
- Retinal Diseases and Treatments
- Lung Cancer Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Endometrial and Cervical Cancer Treatments
- Retinal Imaging and Analysis
- Lung Cancer Treatments and Mutations
- Advanced Breast Cancer Therapies
- BRCA gene mutations in cancer
- Retinal and Optic Conditions
- Brain Metastases and Treatment
- Multiple and Secondary Primary Cancers
- Ovarian cancer diagnosis and treatment
- Intraocular Surgery and Lenses
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Glaucoma and retinal disorders
- Endometriosis Research and Treatment
- Cervical Cancer and HPV Research
- Colorectal Cancer Surgical Treatments
- Cancer, Hypoxia, and Metabolism
- Systemic Lupus Erythematosus Research
- Retinal and Macular Surgery
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
Korea University Medical Center
2019-2024
University of Ulsan
2018-2023
Asan Medical Center
2018-2023
Ulsan College
2018-2023
Dongguk University Ilsan Hospital
2023
Hallym University
2015-2023
Hallym University Kangnam Sacred Heart Hospital
2012-2021
Samsung Medical Center
2015-2020
Sungkyunkwan University
2015-2020
Seoul St. Mary's Hospital
2012
In Brief Purpose: To assess the effects of verteporfin photodynamic therapy (PDT) combined with ranibizumab or alone versus monotherapy in patients symptomatic macular polypoidal choroidal vasculopathy. Methods: this multicenter, double-masked, primarily indocyanine green angiography–guided trial, 61 Asian were randomized to PDT (standard fluence), 0.5 mg, combination. Patients administered PDT/placebo and initiated three consecutive monthly ranibizumab/sham injections starting Day 1,...
Polypoidal choroidal vasculopathy (PCV) is an exudative maculopathy affecting vision, with clinical features distinct from neovascular age-related macular degeneration. Currently, no evidence-based guidelines exist for its diagnosis and treatment.A panel of experts analyzed a systematic literature search on PCV together results the EVEREST trial, only published randomized controlled trial in PCV. At subsequent Roundtable meeting, recommendations management were agreed based this analysis...
Idiopathic pulmonary fibrosis (IPF) is associated with fatal complications after radiotherapy (RT) for lung cancer patients; however, the role of proton therapy to reduce incidence life-threatening unclear. Herein, we present preliminary results early-stage patients having IPF and treated RT, a focus on comparison between X-ray therapy. From January 2010 October 2017, retrospectively reviewed medical records 264 stage I-II non-small cell (NSCLC) definitive RT alone. Ultimately, 30 (11.4%)...
There is uncertainty over the effect of systemic inflammatory response on oncologic outcomes in patients who underwent neoadjuvant chemoradiotherapy and surgery for rectal cancer. We investigated association between neutrophil-lymphocyte ratio (NLR) platelet-lymphocyte (PLR) as markers inflammation tumor prognosis after treatment.A total 176 curative cancer were analyzed retrospectively. Pretreatment hematologic parameters main clinical factors tumors with respect to their relationship...
Objectives To determine the risk factors for retinal microvascular impairment on optical coherence tomography angiography (OCT-A) in type 2 diabetic patients without clinical retinopathy (DR). Methods This retrospective and cross-sectional study enrolled 74 clinically evident DR group 34 healthy subjects control group. OCT-A parameters were measured to vascular density (VD) foveal avascular zone (FAZ) size superficial deep capillary plexuses (SCP/DCP) of retina. Clinical data collected sex,...
Importance The disparate prognostic implications between invasive ductal carcinoma (IDC) and lobular (ILC) have been demonstrated. However, information on premenopausal patients remains insufficient. Objective To examine long-term survival outcomes of ILC IDC in using national databases. Design, Setting, Participants This cohort study used the Surveillance, Epidemiology, End Results (SEER), Korean Breast Cancer Registry (KBCR), Asan Medical Center Research (AMCR) databases to identify with...
To describe the features of foveal microvasculature using optical coherence tomography angiography (OCTA) and to determine related clinical factors in eyes with surgically closed macular hole (MH).A retrospective case series 18 patients unilateral MH was reviewed. The maintained complete closure after vitrectomy inner limiting membrane (ILM) peeling for at least 12 months. healthy fellow were studied as controls. both examined by OCTA. area avascular zone (FAZ) vascular density (VD) ratio...
Objectives: There is no consensus on whether giving adjuvant concurrent chemoradiotherapy (CCRT) more effective than radiotherapy (RT) alone in patients with early stage cervical cancer and intermediate-risk factor(s).The purpose of this study was to evaluate survival difference according treatment the group.Methods: From 2000 2014, medical records IB-IIA a history radical hysterectomy pelvic lymph node dissection, followed by RT at dose ≥40 Gy were retrospectively reviewed.Among these, 316...
Current guidelines recommend definitive radiotherapy for patients with medically inoperable early-stage non-small cell lung cancer (NSCLC). However, the impact of underlying pulmonary diseases on survival in those remains unclear.We retrospectively reviewed medical records 234 stage I-II NSCLC treated alone at Samsung Medical Center between January 2010 and October 2017. We compared outcomes according to presence diseases, including chronic obstructive disease (COPD), combined fibrosis...
As a large-scale study of Koreans, we evaluated the association between BRCA mutation and prevalence non-breast ovary cancers in first- second-degree relatives high-risk breast cancer patients.We organized familial pedigrees 2555 patients with who underwent genetic screening for BRCA1/2 Samsung Medical Center January 2002 May 2018. Families member that had history other than or were regarded positive primary cancer.The median age population was 40 years (range, 19 to 82 years). detected 377...
Abstract Background Our study has aimed to assess the effects of consolidative high-dose radiotherapy on clinical outcomes in patients with localized metastatic non-small cell lung cancer (NSCLC) who showed favorable tumor response after systemic treatment. Methods We retrospectively reviewed medical records 83 NSCLC, received therapy followed by local at Korea University Guro Hospital between March 2017 and June 2022. In current study, we defined disease as presence one three sites time...
The purpose of this study was to determine the clinical parameters related metamorphopsia outcome in patients with resolved central serous chorioretinopathy (CSCR).The charts 36 eyes CSCR were retrospectively reviewed. We measured using M-CHARTS after resolution retinal detachment. analyzed relationship between and including age, visual acuity, chronicity CSCR, symptom duration several spectral-domain optical coherence tomography findings univariate multivariate forward logistic regression...
Aim We evaluated the tumor response and clinical outcomes according to molecular subtypes in stage II–III breast cancer patients who received neo-adjuvant chemotherapy (NAC) followed by surgery radiotherapy. Methods retrospectively analyzed 329 with NAC Luminal A B, HER2-enriched triple-negative subgroups were identified. Results The overall pathologic complete (pCR) rate after was 20.1% subgroup had highest pCR (43.6%), whereas luminal showed lowest of (4.6%). median follow-up duration 55...
Importance Young patients with breast cancer have higher risk for developing contralateral (CBC) and epidemiologic characteristics different from those of older patients. Objective To examine the incidence peak occurrence CBC according to age at primary (PBC) surgery. Design, Setting, Participants This cohort study included who were diagnosed underwent surgery unilateral nonmetastatic Asan Medical Center, Korea, between January 1, 1999, December 31, 2013, follow-up through 2018. Data...
The aim of this study was to evaluate the chronological changes over 14 years in survival Korean patients with breast cancer. We also sought investigate factors that may have influenced rate.We retrospectively analyzed 17,776 cancer who were treated at Asan Medical Center between January 2000 and December 2013. Patient information collected from database, including age diagnosis, clinical manifestation, pathology report, types treatment modality, recurrence, follow-up period. classified into...
Importance Body mass index (BMI) may affect the 21-gene recurrence score (RS) in patients with ER-positive, ERBB2 -negative breast cancer. If high BMI increases genomic risk cancer, weight control will become more important. Objective To assess association between RS and according to age groups address as a factor associated RS. Design, Setting, Participants This cohort study included 2295 cancer who had undergone multigene assay March 29, 2010, December 31, 2020, 2 hospitals. All of were...
In 2018 International Federation of Gynecology and Obstetrics (FIGO) staging system uterine cervix cancer, size criteria primary tumor has been revised. This study aimed to evaluate the validity this new (<2, 2-4, ≧4 cm) in patients who underwent radical hysterectomy adjuvant radiation therapy (RT) for early cervical cancer.We retrospectively examined 312 RT cancer (IB-IIA) from 2001 2014. The effects clinical pathological factors on disease-free survival (DFS) overall (OS) were evaluated...
Importance Contralateral breast cancer (CBC) is the most frequently diagnosed primary in patients with cancer. Although many studies have reported survival after development of CBC, results been inconsistent. Objective To investigate whether CBC associated among Design, Setting, and Participants This cohort study was conducted at Asan Medical Center, Korea, who were unilateral, nonmetastatic, stage 0 to III between 1999 2013 followed up through 2018. The median (IQR) follow-up 107 (75-143)...
This study aimed to evaluate the prognosis of breast cancer patients who received neoadjuvant chemotherapy and underwent sentinel lymph node biopsy (SLNB) alone as axillary surgery regardless their clinical pathological status. We reviewed records 1,795 from Asan Medical Center were diagnosed with stage I–III during 2003–2014. selected 760 SLNB divided these into four groups according (cN) (pN) status: cN(-)pN(-) (n = 377), cN(-)pN(+) 33), cN(+)pN(-) 242), cN(+)pN(+) 108). then compared...
To evaluate the appropriateness of prophylactic inguinal nodal irradiation (PINI), we analyzed patterns failure in anal cancer patients who were node-negative at presentation and did not receive PINI.We retrospectively reviewed records 33 treated by definitive concurrent chemoradiation therapy (CCRT) between 1994 2013. Radiotherapy consisted a total dose 44-45 Gy (22-25 fractions 5 weeks) on whole pelvis, anus, perineum. Except lymphadenopathy was present initial diagnosis, entire chain...