A5065248419- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Cancer Studies
- Ear and Head Tumors
- Tracheal and airway disorders
- Oral and Maxillofacial Pathology
- Head and Neck Surgical Oncology
- Tumors and Oncological Cases
- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Airway Management and Intubation Techniques
- Cancer Diagnosis and Treatment
- Dysphagia Assessment and Management
- Reconstructive Surgery and Microvascular Techniques
- Thyroid and Parathyroid Surgery
- Angiogenesis and VEGF in Cancer
- Vascular Tumors and Angiosarcomas
- Voice and Speech Disorders
- Radiomics and Machine Learning in Medical Imaging
- Cleft Lip and Palate Research
- Lung Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Vascular Malformations and Hemangiomas
- Cancer Research and Treatments
- Neuroendocrine Tumor Research Advances
Samsung Medical Center
2016-2025
Sungkyunkwan University
2016-2025
Government of the Republic of Korea
2023
Harvard University
2015
Duke Medical Center
2015
Massachusetts General Hospital
2015
Hanyang University Guri Hospital
2009
Korea University
2005
National Institutes of Health
2004
Seoul National University
2002
An alternate route for metastatic cells Metastatic tumor are thought to reach distant organs by traveling through the blood circulation or lymphatic system. Two studies of mouse models now suggest a hybrid cell dissemination. Pereira et al. and Brown used distinct methodologies monitor fate in lymph nodes. They found that could invade local vessels within node, exit node entering circulation, then go on colonize lung. Whether this dissemination occurs cancer patients is unknown; answer...
Abstract Purpose: This study aimed to investigate whether metabolic tumor volume (MTV) measured from [18F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) predicts short-term outcome radiotherapy with or without chemotherapy and disease-free survival (DFS) in patients pharyngeal cancers. Experimental Design: The MTVs of primary sites neck nodes were 82 patients. Short-term was assessed using the treatment response evaluation by Response Evaluation Criteria...
Background:To date, antiangiogenic therapy has failed to improve overall survival in cancer patients when used the adjuvant setting (local-regional disease with no detectable systemic metastasis). The presence of lymph node metastases worsens prognosis, however their reliance on angiogenesis for growth not been reported.
Summary Objective To compare the diagnostic accuracy of integrated 18 F‐fluorodeoxyglucose PET/CT with ultrasonography (US) and contrast enhanced CT (CECT) alone in initial evaluation cervical lymph node levels patients papillary thyroid carcinoma. Patients measurements From July 2004 to March 2005, 26 consecutive carcinoma, confirmed by aspiration cytology analysis, underwent US, CECT PET/CT. The sensitivity, specificity studies for final status 312 (levels I–V: 260, level VI: 52) were...
The reported incidence of facial weakness immediately after parotid tumor surgery ranges from 14 to 65%. purpose this study was evaluate the postoperative related parotidectomy with use preoperative computed tomography (CT), intraoperative nerve monitoring, and surgical magnification. Also, we sought elucidate additional information about risk factors for in surgery, particularly focusing on subsites.We retrospectively reviewed 794 cases benign malignant tumors arising gland (2009-2016)....
The composition of RNase H2 has been a long‐standing problem. Whereas bacterial and archaeal RNases are active as single polypeptides, the Saccharomyces cerevisiae homolog, Rnh2Ap, when expressed in Escherichia coli, fails to produce an H2. By affinity chromatography purification identification polypeptides associated with tagged S.cerevisiae we obtained complex three proteins (Rnh2Ap, Ydr279p Ylr154p) that together necessary sufficient for activity. Deletion gene encoding any one or...
Abstract Fibroblastic reticular cells (FRCs) are immunologically specialized myofibroblasts of lymphoid organ, and FRC maturation is essential for structural functional properties lymph nodes (LNs). Here we show that YAP TAZ (YAP/TAZ), the final effectors Hippo signaling, regulate commitment maturation. Selective depletion YAP/TAZ in FRCs impairs growth differentiation compromises organization LNs, whereas hyperactivation enhances myofibroblastic characteristics aggravates LN fibrosis....
ABSTRACT Background The diagnosis of oral squamous cell carcinoma (OSqCC) is sometimes delayed. In this study, we attempted to comprehensively analyze the surface and cross section OSqCC using whole‐mount sections. Methods Representative sections 41 pT2 pT3 were digitally assembled, reconstructed. tumor, degree differentiation was classified as well/moderately differentiated (WDMD) poorly (PD); specimen divided into four types: benign‐looking epithelium, dysplasia, carcinoma, ulceration....
Lymph node metastasis (LNM) in many solid cancers is a well-known prognostic factor; however, it has been debated whether regional LNM simply reflects tumor aggressiveness or source for further dissemination. Similarly, the metastatic process head and neck cancer (HNC) not fully evaluated. Thus, we aimed to investigate relative significance of cascade HNC using functional imaging patients molecular vivo models. First, analyzed (18)Fluorodeoxyglucose positron emission tomography (PET)...
Salivary duct carcinoma (SDC) is a highly aggressive subtype of salivary gland cancers and there no established standard therapy for this disease. Thus, development molecular markers SDC will be important to guide the diagnosis tumor. We performed next-generation sequencing using Ion Torrent AmpliSeq cancer panel, which explores mutational status hotspot regions in 50 cancer-associated genes, we analyzed copy number variations (CNVs) 21 genes by NanoString nCounter 37 patients with SDC....
To introduce a new injection material for vocal fold diseases, which could be readily translated to clinical practice, we investigated the effectiveness of platelet-rich plasma (PRP) on injured in terms histological recovery.Blood samples were drawn from New Zealand White rabbits and PRP was isolated through centrifugation separation samples. Using CO2 laser, made linear wound 24 sides 12 injected each with one side normal saline (NS) other. Morphologic analyses conducted at 2, 4, weeks...
High-grade salivary gland cancer is a distinct clinical entity that has aggressive disease progression and early systemic spread. However, because of the rarity disease, outcomes, prognostic factors decision on optimal treatments have not been fully understood.In this study, we retrospectively analyzed data 124 patients with high-grade cancers performed multivariate survival analyses to evaluate clinico-pathological affecting treatment outcomes.The 5-year disease-specific was 63.4% in...
The purpose of this study was to investigate the clinical usefulness PET/CT or CT-attenuated PET in evaluation patients with oral cavity cancer (OCC) whom dental artifacts distorted conventional CT MR images cavity. <b>Methods:</b> A scan, addition a MRI performed 69 OCC who had dentures implants. total 64 PET/CT, CT, and 27 were analyzed including from scans on 40 without images; these used for comparison. scan detection primary tumors compared scan. We also evaluated correlation between...
Abstract We describe the effect of recombinant canstatin, NC1 domain α2 chain Type IV collagen, on suppression angiogenesis and lymphangiogenesis both in vitro vivo . Recombinant canstatin produced from stably transformed Drosophila S2 cells reduced expression angiopoietin‐1 hypoxia mimetic agent, CoCl 2 ‐treated CT‐26 cells. inhibited proliferation, tube formation migration human (rhAngpt‐1)‐treated umbilical vein endothelial (HUVEC) lymphatic (LEC). suppressed Tie‐2 vascular growth...