A5101917897- Salivary Gland Tumors Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Blood Pressure and Hypertension Studies
- Ear and Head Tumors
- Head and Neck Cancer Studies
- Head and Neck Anomalies
- Ear Surgery and Otitis Media
- Heart Rate Variability and Autonomic Control
- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Disaster Response and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related molecular mechanisms research
- Oral and Maxillofacial Pathology
- Tracheal and airway disorders
- Head and Neck Surgical Oncology
- Climate Change and Health Impacts
- Cardiovascular Health and Disease Prevention
- Cancer Genomics and Diagnostics
- Airway Management and Intubation Techniques
- Teratomas and Epidermoid Cysts
- Cardiac and Coronary Surgery Techniques
- Cellular Mechanics and Interactions
- Biomarkers in Disease Mechanisms
National Cancer Center
2023-2025
Samsung Medical Center
2011-2022
Sungkyunkwan University
2011-2022
Soonchunhyang University Hospital
2018-2022
Eulji University
2021-2022
Korea Advanced Institute of Science and Technology
2015-2020
Institute for Basic Science
2018-2020
Hanyang University
2015-2016
Catholic University of Daegu
2009-2016
Zero to Three
2012
The upper respiratory tract is compromised in the early period of COVID-19, but SARS-CoV-2 tropism at cellular level not fully defined. Unlike recent single-cell RNA-Seq analyses indicating uniformly low mRNA expression entry–related host molecules all nasal epithelial cells, we show that protein levels are relatively high and their localizations restricted to apical side multiciliated cells. In addition, provide evidence patients with COVID-19 massively detected replicated within We...
Optical energy can trigger a variety of photochemical processes useful for therapies.Owing to the shallow penetration light in tissues, however, clinical applications light-activated therapies have been limited.Bioluminescence resonant transfer (BRET) may provide new way inducing activation.Here, we show that efficient bioluminescence energy-induced photodynamic therapy (PDT) macroscopic tumors and metastases deep tissue.For monolayer cell culture vitro incubated with Chlorin e6, BRET about...
Abstract Fibroblastic reticular cells (FRCs) are immunologically specialized myofibroblasts of lymphoid organ, and FRC maturation is essential for structural functional properties lymph nodes (LNs). Here we show that YAP TAZ (YAP/TAZ), the final effectors Hippo signaling, regulate commitment maturation. Selective depletion YAP/TAZ in FRCs impairs growth differentiation compromises organization LNs, whereas hyperactivation enhances myofibroblastic characteristics aggravates LN fibrosis....
BackgroundActive surveillance (AS) has emerged as a viable management strategy for low-risk papillary thyroid microcarcinoma (PTMC), following pioneering trials at Kuma Hospital and the Cancer Institute in Japan. Numerous prospective cohort studies have since validated AS option PTMC, leading to its inclusion cancer guidelines across various countries. From 2016 2020, Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) enrolled 1,177...
Objective: To assess the factors affecting health-related quality of life (HRQOL) after ear surgery in patients with chronic otitis media (COM).Design: Prospective questionnaire-based outcome study.Setting: Tertiary care institution. Patients:The study population comprised 205 aged 21 to 67 years referred for owing COM or without cholesteatoma between November 2009 and March 2011. Interventions:The included tympanoplasty, mastoidectomy.The Korean version Chronic Ear Survey (K-CES), a...
Objectives This study aimed to evaluate the significance of metastatic lymph node ratio (the between and harvested nodes; MLNR) in central neck for prediction locoregional recurrence patients with papillary thyroid microcarcinoma. Methods After reviewing medical records microcarcinoma who received total thyroidectomy dissection, 573 consecutive adult were enrolled this study, a follow-up period more than 36 months. Regarding risk recurrence, multivariate analyses performed following...
Background: Recurrence in pleomorphic adenoma (PA) has been debated as a risk factor for malignant transformation (MT). In this study, we investigated whether recurrence is MT, by longitudinally analyzing cases with recurrent PA (RPA), and carcinomas from (CXPA) or RPA (CXRPA). Methods: The study population included 24 CXPA, RPA, 6 CXRPA, 386 (study period 2010–2018). Time event data were collected the medical documents to identify time–event sequences. Results: time interval MT CXRPA was...
Objective To investigate the efficacy of fibrin sealant (FS) for reducing postoperative drainage in patients who underwent total thyroidectomy (TT) with bilateral central neck dissection (CND) papillary thyroid cancer. Study Design Prospective randomized trial. Setting Tertiary care institution. Subjects and Methods Seventy‐eight cancer were enrolled to either FS application group (FS+, 38 patients) or no (FS–, 40 patients). In both groups, amounts measured by a negative suction system until...
Abstract Thyroid gland vasculature has a distinguishable characteristic of endothelial fenestrae, critical component for proper molecular transport. However, the signaling pathway that critically governs maintenance thyroid vascular integrity, including is poorly understood. Here, we found profound and distinct expression follicular epithelial VEGF ‐A VEGFR 2 were precisely regulated by circulating thyrotropin, while there no meaningful angiopoietin–Tie2 system in gland. Our genetic...
Despite an association between visit-to-visit blood pressure (BP) variability (VV-BPV) and cardiovascular (CV) outcomes, many studies performed during the past 4 years have shown conflicting results. This study investigated impact of VV-BPV on CV outcomes in Korean National Health Insurance Service (NHIS) database-National Sample Cohort.From 2002 NHIS database (n = 47,851,928), sample subjects with 3 or more BP measurements 51,811) were divided into 2 groups according to a 10 mm Hg cutoff SD...
Although intraoral resection of small-sized tonsil cancer achieves excellent tumor control, the extent local invasion and adequate safety margin in have not been studied. Thus, we aim to determine terms mucosal spread deep infiltration stage T1-2 cancer.We re-analyzed surgical specimens from 49 cT1-2 cancers. Microscopic cell extension gross boundary was assessed representative sections each tumor. We also tested whether correlates with human papilloma virus (HPV) status tumors.The...
Objectives Length of in-hospital stay (LOS) is often regarded as a surrogate marker efficiency in medical care. A shorter can redistribute resources to more patients if patient outcomes would not be worsened. However, the adequate LOS remains largely understudied for complex head and neck cancer (HNC) surgery free flap reconstruction. Methods Active management (14-day program) included detailed preoperative surgical planning, intensive wound care, postoperative early ambulation positive...
Abstract Background Early detection and diagnosis of parotid gland cancer (PGC) are essential to improve clinical outcomes, because Tumor-Node-Metastasis stage at is a very strong indicator prognosis in PGC. Nevertheless, some patients still present with large mass, maybe due the unawareness or ignorance their disease. In this study, we aimed outcomes bulky PGC (defined by 4 cm cutoff point for T3–4 versus T1–2 tumors), emphasize necessity self-examination tool tumor. Methods We...
Objective To investigate the clinical efficacy of ultrasonographic (US) classification additional thyroid nodules coexisting with proven papillary microcarcinoma (PTMC). Study Design Historical cohort study. Setting Tertiary care institution. Subjects and Methods In addition to prevalence based on an US classification, diagnostic accuracy predictive factors for malignancy were assessed in 300 randomly selected from patients cytologically PTMC who underwent total thyroidectomy. Results The...
Objectives Although human papillomavirus (HPV) infection is considered as a favorable prognostic factor in oropharyngeal cancer, the prognosis of HPV-associated tonsil cancer has rarely been studied especially when surgery was main treatment. In this study, authors investigated effect p16 over-expression (HPV infection) on according to type treatment, HPV presence by PCR, and expression p53 epidermal growth receptor (EGFR) immunohistochemistry (IHC). Methods Medical records 33 patients were...
Abstract Background This study analyzed the characteristics of hydrogen fluoride-exposed patients (HFEPs) treated in emergency department (ED) a local university hospital, and reviewed hospital’s disaster response according to space, staff, supplies, systems (4Ss). Methods retrospective observational chart review descriptive included 199 HFEPs among 2588 total ED who visited medical center for treatment between September 27, 2012 October 20, 2012, following hydrofluoric acid leak at Hube...
The aim of this study was to evaluate the mediating effects nocturnal blood pressure (BP) and morning surge on contribution arterial stiffness sodium intake BP in a middle-aged general population.The included 124 subjects aged 30-59 years, from rural Yeoju County, Gyeonggi Province, South Korea. Ambulatory monitoring, 24 h urinary excretion (24 UNa) brachial-ankle pulse wave velocity (baPWV) measurements were performed all subjects.The mean ± SD age 48.1 8.2 years proportion male 41.1%....