A5037578765- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- BRCA gene mutations in cancer
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Head and Neck Anomalies
- Parathyroid Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- RNA Research and Splicing
- Voice and Speech Disorders
- Airway Management and Intubation Techniques
- Radiation Dose and Imaging
- Circular RNAs in diseases
- Hormonal Regulation and Hypertension
- Cardiac, Anesthesia and Surgical Outcomes
- Glioma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Surgical Simulation and Training
- Patient-Provider Communication in Healthcare
- Radiology practices and education
- Ovarian cancer diagnosis and treatment
The University of Sydney
2016-2025
The Kinghorn Cancer Centre
2020-2025
UNSW Sydney
2015-2025
Northern Sydney Local Health District
2015-2025
St Vincent's Clinic
2020-2025
Kettering University
2022-2025
Memorial Sloan Kettering Cancer Center
2022-2025
Garvan Institute of Medical Research
2020-2025
Royal North Shore Hospital
2015-2024
Yonsei University
2023
BACKGROUND Papillary thyroid cancer (PTC) persistence or recurrence and the need for long‐term surveillance can cause significant inconvenience morbidity in patients. Currently, risk stratification is accomplished by using clinicopathologic factors, serum thyroglobulin only commercially available marker persistent recurrent disease. The objective of this study was to determine microRNA (miRNA) expression PTC whether 1 more miRNAs could be measured plasma as a biomarker recurrence. METHODS...
Medullary thyroid carcinoma (MTC) is an aggressive neuroendocrine tumor (NET) arising from the calcitonin-producing C cells. Unlike other NETs, there no widely accepted pathologic grading scheme. In 2020, two groups separately developed slightly different schemes (the Memorial Sloan Kettering Cancer Center and Sydney grade) on basis of proliferative activity (mitotic index and/or Ki67 index) necrosis. Building this work, we sought to unify validate internationally scheme for MTC.Tumor tissue...
RBM10 modulates transcriptome-wide cassette exon splicing. Loss-of-function mutations are enriched in thyroid cancers with distant metastases. Analysis of transcriptomes and genes mis-spliced by loss showed pro-migratory RHO/RAC signaling signatures. increases cell velocity. Cytoskeletal ECM transcripts subject to inclusion events included vinculin (VCL), tenascin C (TNC), CD44. Knockdown the VCL transcript RBM10-null cells reduced velocity, whereas knockdown TNC CD44 isoforms invasiveness....
// Anthony R. Glover 1, 2, 9, * , Jing Ting Zhao J. Gill 3 Jocelyn Weiss 4 Nancy Mugridge Edward Kim 2 Alex L. Feeney Julian C. Ip Glen Reid 5 Stephen Clarke 6 Patsy S.H. Soon 7 Bruce G. Robinson 8 Himanshu Brahmbhatt Jennifer A. MacDiarmid Stan B. Sidhu 9 1 Cancer Genetics Laboratory, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia Medical School Northern, Royal North Shore Hospital, University of Sydney, Department Anatomical Pathology, Hospital and...
We investigated the prognostic value of a range histologic parameters in medullary thyroid carcinoma (MTC) to design grading system predict overall survival. assessed 76 patients with MTCs undergoing primary tumor resection for age, sex, size, vascular space invasion, lymph node metastasis, multiple endocrine neoplasia type 2 (MEN2) status, mitotic count, Ki-67 proliferative index, spindled morphology, sheet-like growth pattern, coagulative necrosis, incipient nuclear grade, multinucleation,...
Purpose: The prognostic importance of RET and RAS mutations their relationship to clinicopathologic parameters outcomes in medullary thyroid carcinoma (MTC) need be clarified.
Adrenocortical carcinoma (ACC) is an aggressive malignancy with high rates of recurrence following surgical resection. Long noncoding RNAs (lncRNAs) play important role in cancer development. Pathogenesis adrenal tumours have been characterised by mRNA, microRNA and methylation expression signatures, but it unknown if this extends to lncRNAs. This study describes lncRNA signatures ACC, cortical adenoma (ACA) normal cortex (NAC) presents lncRNAs associated ACC identify novel prognostic...
Abstract: Adrenal cortical carcinoma (ACC) is a rare cancer that poses number of management challenges due to the limited effective systemic treatments. Complete surgical resection offers best chance long-term survival. However, despite complete resection, ACC associated with high recurrence rates. This review will discuss recurrent in adults following resection. Management should take place specialist center and treatment decisions must consider individual tumor biology each case...
Low-risk differentiated thyroid cancers may, according to the American Thyroid Association (ATA) 2015 guidelines, be managed initially with lobectomy. However, definitive risk categorization requires pathological assessment of specimen, resulting in completion thyroidectomy being recommended when discordance between preoperative and postoperative staging occurs. This study sought establish expected rate patients papillary cancer (PTC) treated by lobectomy.Patients PTC over 5 years (2013-2017...
There remains uncertainty regarding the optimal extent of initial surgery and management recurrent disease in medullary thyroid cancer (MTC). We aim to describe patterns recurrence outcomes reoperative a cohort consecutively treated patients at specialized tertiary referral center.A retrospective study 235 surgically with MTC center was performed using prospectively collected data.In period 1986-2022, underwent for MTC. Of these, 45 (19%) had cervical nodal median (range) 2.1 (0.3-16) years...
BackgroundActive surveillance (AS) has emerged as a viable management strategy for low-risk papillary thyroid microcarcinoma (PTMC), following pioneering trials at Kuma Hospital and the Cancer Institute in Japan. Numerous prospective cohort studies have since validated AS option PTMC, leading to its inclusion cancer guidelines across various countries. From 2016 2020, Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) enrolled 1,177...
Management of sporadic medullary thyroid microcarcinoma smaller than 1 cm (micro-MTC) is controversial because conflicting reports prognosis. As these cancers are often diagnosed incidentally, they pose a management challenge when deciding on further treatment and follow-up.We report the outcomes surgically managed micro-MTC in specialist endocrine surgery endocrinology unit identify associations for recurrence disease-specific survival this population.Micro-MTCs were identified from...
Aims Recently, there have been attempts to improve prognostication and therefore better guide treatment for patients with medullary thyroid carcinoma (MTC). In 2022, the International MTC Grading System (IMTCGS) was developed validated using a multi‐institutional cohort of 327 patients. The aim current study build upon findings IMTCGS develop validate prognostic nomogram predict recurrence‐free survival (RFS) in MTC. Methods Results Data from 300 five centres across USA, Europe, Australia...
Objectives The study aims to investigate the perceptions of patients with thyroid cancer on potential impact diagnosis and treatment delays during COVID-19 pandemic. Design This involved qualitative semi-structured telephone interviews. interviews were transcribed verbatim, analysed using thematic framework analysis method reported Consolidated Criteria for Reporting Qualitative Research. Setting Participants in treated and/or managed at hospital sites across New South Wales Victoria,...