A5084851276- Sarcoma Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Renal and related cancers
- Mast cells and histamine
- Dermatology and Skin Diseases
- Retinal Diseases and Treatments
- Allergic Rhinitis and Sensitization
- Parvovirus B19 Infection Studies
- Dermatologic Treatments and Research
- Tumors and Oncological Cases
- Soft tissue tumor case studies
- Retinal and Optic Conditions
- Oral and Maxillofacial Pathology
- Medical Imaging and Pathology Studies
- Vascular Tumors and Angiosarcomas
- Asthma and respiratory diseases
- Lymphoma Diagnosis and Treatment
- Urticaria and Related Conditions
- Bone health and treatments
- Cytomegalovirus and herpesvirus research
- Congenital Diaphragmatic Hernia Studies
- Renal Diseases and Glomerulopathies
- Neuroblastoma Research and Treatments
- Parathyroid Disorders and Treatments
- Retinal Imaging and Analysis
Children's Hospital at Westmead
2016-2025
The University of Sydney
2010-2025
Sydney Children’s Hospitals Network
2019-2024
Camden and Campbelltown Hospitals
2020-2024
Western Sydney University
2018-2024
Kantonsspital St. Gallen
2022
University of St. Gallen
2021
Engeriedspital
2021
Scuola Normale Superiore
2021
Universidad del Desarrollo
2021
DICER1 is crucial for embryogenesis and early development. Forty different heterozygous germline mutations have been reported worldwide in 42 probands that developed as children or young adults, pleuropulmonary blastoma (PPB), cystic nephroma (CN), ovarian sex cord-stromal tumors (especially Sertoli-Leydig cell tumor [SLCT]), and/or multinodular goiter (MNG). We report seven additional families manifested uterine cervix embryonal rhabdomyosarcoma (cERMS, four cases) primitive neuroectodermal...
Objectives To identify predictive parameters for the progression of skin fibrosis within 1 year in patients with diffuse cutaneous SSc (dcSSc). Methods An observational study using EUSTAR database was performed. Inclusion criteria were dcSSc, American College Rheumatology (ACR) fulfilled, modified Rodnan score (MRSS) ≥7 at baseline visit, valid data MRSS 2nd and available follow-up 12±2 months. Worsening defined as increase >5 points ≥25% from to visit. In univariate analysis, progressive...
(See the editorial commentary by Pereira, on pages 1510–2.) Background. Human cytomegalovirus (CMV) is most common congenital infection in developed countries and a known cause of intrauterine fetal death. We examined CMV stillbirths relationship with histopathological findings at autopsy. Methods. collected liver, kidney, placenta specimens from 130 stillbirths. DNA protein were detected using polymerase chain reaction immunohistochemistry, along routine autopsy stillborn infants. Results....
To determine whether progressive skin fibrosis is associated with visceral organ progression and mortality during follow-up in patients diffuse cutaneous systemic sclerosis (dcSSc).We evaluated from the European Scleroderma Trials Research database dcSSc, baseline modified Rodnan score (mRSS) ≥7, valid mRSS at 12±3 months after ≥1 annual visit. Progressive was defined as an increase >5 ≥25% to months. Outcomes were pulmonary, cardiovascular renal progression, all-cause death. Associations...
Human cytomegalovirus (CMV) infection of the developing fetus can result in adverse pregnancy outcomes including death utero. Fetal injury results from direct viral cytopathic damage to CMV-infected fetus, although evidence suggests CMV placental may indirectly cause possibly via immune dysregulation with dysfunction. This study investigated effects on expression chemokine MCP-1 (CCL2) and cytokine TNF-α placentae naturally infected stillborn babies, compared these changes those found...
Improvement of skin fibrosis is part the natural course diffuse cutaneous systemic sclerosis (dcSSc). Recognising those patients most likely to improve could help tailoring clinical management and cohort enrichment for trials. In this study, we aimed identify predictors improvement in with dcSSc.We performed a longitudinal analysis European Scleroderma Trials And Research (EUSTAR) registry including dcSSc, fulfilling American College Rheumatology criteria, baseline modified Rodnan score...
Abstract In patients with early head and neck squamous cell carcinoma (HNSCC), occult lymph node metastasis is difficult to predict by clinical or pathological parameters. However, such parameters are necessary select either for elective dissection the sentinel (SLN) procedure. The membrane glycoprotein podoplanin normally expressed in lymphatic endothelial cells. Recently, expression of cancer cells was demonstrated promote tumor motility lymphangiogenesis vitro . value cell‐expressed be...
To evaluate the incidence of presumed endophthalmitis (EO) after intravitreal injection (IVI) anti-vascular endothelial growth factor agents performed in operating room.Retrospective study at 2 Swiss eye hospitals between 2004 and 2012. Hospital records were used to identify patients treated with an IVI agent 2012 those for EO, defined as any intraocular inflammation antibiotics. All IVIs using standard sterile technique a Class 1 room. No patient received preinjection topical Postinjection...
To evaluate the effect of systemic interleukin 1β inhibition using canakinumab (Ilaris) on retinal neovascularizations in proliferative diabetic retinopathy.Patients with retinopathy were enrolled a prospective uncontrolled pilot study. Canakinumab (150 mg) was given 3 times subcutaneously. The primary end point change area neovascularization from baseline to Week 24. Secondary points edema measured and best-corrected visual acuity (BCVA), as well safety evaluation, HbA1c, inflammatory...
<b><i>Background/Aims: </i></b>Sclerostin is secreted by osteocytes. As a circulating inhibitor of the Wnt-signaling pathway it inhibits bone formation and contributes to development osteoporosis. Sclerostin levels are elevated in patients with chronic kidney disease end-stage renal disease. Since data for after transplantation scarce, we have prospectively measured sclerostin before during first year examined association parameters mineral metabolism density....
Objectives Mortality and worsening of organ function are desirable endpoints for clinical trials in systemic sclerosis (SSc). The aim this study was to identify factors that allow enrichment patients with these endpoints, a population from the European Scleroderma Trials Research group database. Methods Inclusion criteria were diagnosis diffuse SSc follow-up over 12±3 months. Disease worsening/organ progression fulfilled if any following events occurred: new renal crisis; decrease lung or...
Prognostic factors in predicting occult lymph node metastasis patients with head and neck squamous-cell carcinoma (HNSCC) are necessary to improve the results of sentinel procedure this tumour type. The E-Cadherin glycoprotein is an intercellular adhesion molecule epithelial cells, which plays important role establishing maintaining connections. To determine value molecular marker regional metastatic disease. expression tissue 120 HNSCC oral cavity oropharynx were evaluated using microarray...
To assess the influence of age and sex on 10 cerebrospinal fluid (CSF) flow dynamics parameters measured with an MR phase contrast (PC) sequence within cerebral aqueduct at level intercollicular sulcus.128 healthy subjects (66 female a mean 52.9 years 62 male 51.8 years) normal Evans index, medial temporal atrophy (MTA) score, without known disorders CSF circulation were included in study. A PC 3T scanner was used. Ten different analyzed using postprocessing software. Ordinal linear...