A5050008450- Diabetes Management and Research
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Diabetes and associated disorders
- Blood Pressure and Hypertension Studies
- Pancreatic function and diabetes
- Cardiovascular Health and Disease Prevention
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Retinopathy of Prematurity Studies
- Thyroid Cancer Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Heart rate and cardiovascular health
- Renal and Vascular Pathologies
- Thyroid Disorders and Treatments
- Glaucoma and retinal disorders
- Adolescent and Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Immune Response and Inflammation
- Thyroid and Parathyroid Surgery
- Diabetes, Cardiovascular Risks, and Lipoproteins
- NF-κB Signaling Pathways
- Obesity, Physical Activity, Diet
- Cardiovascular Syncope and Autonomic Disorders
The University of Sydney
2015-2025
Children's Hospital at Westmead
2016-2025
Sydney Children’s Hospitals Network
2025
Westmead Institute
2016-2020
Camden and Campbelltown Hospitals
2019-2020
Wellcome/MRC Institute of Metabolic Science
2014
University of Cambridge
2014
Wellcome Trust
2014
OBJECTIVE To describe retinal microvascular geometric parameters in young patients with type 1 diabetes. RESEARCH DESIGN AND METHODS Patients diabetes (aged 12–20 years) had clinical assessments and photography following standardized protocol at a tertiary-care hospital Sydney. Retinal geometry, including arteriolar venular tortuosity, branching angles, optimality deviation, length-to-diameter ratio (LDR), were measured from digitized photographs. Associations of these characteristics...
There is a paucity of data regarding the association between glycosylated hemoglobin (HbA1c) variability and risk microvascular complications in adolescents with type 1 diabetes (T1D).To investigate HbA1c T1D.Prospective cohort study from 1990 to 2014 (median follow-up, 8.1 y).Tertiary pediatric hospital.A total 1706 (aged 12-20 minimum duration 5 y) median age 15.9 years (interquartile range, 14.3-17.5) (6.3-10.8).Glycemic was computed as SD all measurements (SD-HbA1c) after diagnosis....
Objective To compare rates of microvascular complications in adolescents with type 1 diabetes treated continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDI). Research Design and Methods Prospective cohort 989 patients (aged 12–20 years; duration >5 years) CSII or MDI for >12 months. Microvascular were assessed from 2000–14: early retinopathy (seven-field fundal photography), peripheral nerve function (thermal vibration threshold testing), autonomic abnormality...
To examine the hypothesis that vitamin D deficiency (VDD) is associated with an increased prevalence of microvascular complications in young people type 1 diabetes.In a cross-sectional study 517 patients, 25-hydroxyvitamin was measured. Retinopathy assessed by 7-field stereoscopic retinal photography, peripheral neuropathy thermal and vibration threshold testing, microalbuminuria albumin excretion rate or albumin-to-creatinine ratio.Retinopathy higher cases VDD versus sufficiency (18 vs. 9%,...
To examine the association between retinal vascular geometry and subsequent development of incident retinopathy in young patients with type 1 diabetes.A prospective cohort study 736 people diabetes aged 12 to 20 years, retinopathy-free at baseline, attending an Australian tertiary care hospital. Retinopathy was determined from seven-field photographs according modified Airlie House Classification. Retinal geometry, including length/diameter ratio (LDR) simple tortuosity (ST), quantified...
OBJECTIVE To examine the relationship between retinal vascular geometry parameters and development of incident renal dysfunction in young people with type 1 diabetes. RESEARCH DESIGN AND METHODS This was a prospective cohort study 511 adolescents diabetes at least 2 years duration, normal albumin excretion rate (AER) no retinopathy baseline while attending an Australian tertiary-care hospital. AER quantified using three overnight, timed urine specimen collections early defined as >7.5...
Abstract The aim of this cross-sectional study was to compare plasma C-peptide presence and levels in people without diabetes (CON) with Type 1 relate status clinical factors. In a subset we evaluated 50 microRNAs (miRs) previously implicated beta-cell death associations levels. Diabetes age onset stratified as adult (≥ 18 y.o) or childhood (< y.o.), duration ≤ 10 years, 10–20 years > 20 years. Plasma measured by ultrasensitive ELISA. miRs were quantified using TaqMan probe-primer mix...
Purpose.: Adolescent females with type 1 diabetes (T1D) are reported to have greater risk of early microvascular complications than males. We hypothesize sex differences in retinal vascular geometry (RVG) through puberty associated earlier-onset complications. Methods.: Prepubertal patients (n = 64, 35 male) T1D, complication-free at baseline, were followed sexual maturity detailed Tanner-staging and repeated assessments. Retinal from digitized photographs each visit was assessed using a...
Objective To assess feasibility of overnight closed-loop therapy in young children with type 1 diabetes and contrast closed loop using diluted versus standard insulin strength. Research design methods Eleven (male 6; age range 3.75–6.96 years; glycated hemoglobin 60 (14) mmol/mol; body mass index SD score 1.0 (0.8); duration 2.2 (1.0) years, mean (SD); total daily dose 12.9 (10.6, 16.5) IU/day, median (IQR)) were studied at a clinical research facility on two occasions. In random order,...
Baseline data from the Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) indicated that tertiles of urinary albumin-to-creatinine ratios (ACRs) in normal range at age 10-16 years are associated with risk markers for diabetic nephropathy (DN) and cardiovascular disease (CVD). We aimed to determine whether top ACR tertile remained DN CVD over 2-4-year AdDIT study.One hundred fifty adolescents (mean 14.1 [SD 1.6]) baseline upper (high-ACR group) recruited trial, who untreated,...
Aim: Data on the impact of metabolic dysfunction-associated fatty liver disease (MAFLD) diabetes complications in youth with type 1 are lacking. However, MAFLD is well known to contribute cardiovascular (CVD) people 2 diabetes. We aimed investigate markers and their relationship chronic complications. Methods: A prospective study 102 adolescents (mean age 14.7 ± 1.9 years) underwent repeated annual assessments, including measures enzymes. Early cardiac autonomic nerve dysfunction (CAN) was...
OBJECTIVE This study examined the association between cardiac autonomic dysfunction and high albumin-to-creatinine ratio (ACR) in adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS Adolescents recruited as part of a multicenter screening (n = 445, 49% female, aged 10–17 years, mean duration 6.9 years; HbA1c 8.4%, 68 mmol/mol) underwent 10-min continuous electrocardiogram recording for heart rate variability analysis. Time-domain measures included baseline rate, SD R-R interval...
To examine QT intervals corrected for heart rate (QTc) in adolescents with Type 1 diabetes compared control subjects, and to determine associations metabolic autonomic function.Resting electrocardiogram recordings of 142 [mean (sd) age 15.3 (2.0) years, duration 9.0 (3.5) HbA1c 71 (17) mmol/mol or 8.7 (1.6)%] 125 subjects 15.7 (2.5) years] were used calculate QTc derive mean variability (HRV) values. Linear logistic regression models the between QTc, function (HRV pupillary function).QTc was...
OBJECTIVE Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes. However, date, there are no available data on adjunct noninsulin medications this population. Our aim was assess ACE inhibitors and statins explore potential determinants RESEARCH DESIGN AND METHODS There were 443 diabetes recruited into the Adolescent Type Diabetes Cardio-Renal Intervention Trial (AdDIT) exposed two oral drugs—an inhibitor statin—as well as combinations of both or...
Objective: To describe the natural history of vitamin D deficiency in an at-risk population African migrants living Sydney. Design, setting and participants: Opportunistic study 25-hydroxyvitamin [25(OH)D] concentrations over time a community-based cohort North refugee families south-western As part health-screening program, serum 25(OH)D, parathyroid hormone (PTH), calcium, phosphate (PO4) alkaline phosphatase (ALP) were measured September 2006 (end winter, T1). Results for 25(OH)D made...
To examine the association between glycaemic control, insulin resistance and hyperandrogenism on cardiac autonomic function in peripubertal girls with type 1 diabetes.Prospective, clinic-based study of 125 diabetes 46 age-matched nondiabetic girls.Heart rate variability (HRV) parameters derived from a 10-min ECG recording using LabChart Pro were as follows: standard deviation mean NN intervals (SDNN), where = adjacent QRS complexes; root squared difference successive (RMSSD) - estimates...