A5037657546- Breast Cancer Treatment Studies
- Advanced Biosensing Techniques and Applications
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Single-cell and spatial transcriptomics
- Advanced Breast Cancer Therapies
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- bioluminescence and chemiluminescence research
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Thyroid Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Cell Image Analysis Techniques
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Thyroid and Parathyroid Surgery
- Cancer Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- BRCA gene mutations in cancer
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
University of North Carolina at Chapel Hill
2020-2025
UNC Lineberger Comprehensive Cancer Center
2021-2025
Memorial Sloan Kettering Cancer Center
2019-2022
Medical College of Wisconsin
2022
Duke Medical Center
2022
University of Miami
2022
Sylvester Comprehensive Cancer Center
2022
Policlinico S.Orsola-Malpighi
2020
University of Bologna
2020
University of Iowa
2006-2017
Medullary thyroid carcinoma (MTC) is an aggressive neuroendocrine tumor (NET) arising from the calcitonin-producing C cells. Unlike other NETs, there no widely accepted pathologic grading scheme. In 2020, two groups separately developed slightly different schemes (the Memorial Sloan Kettering Cancer Center and Sydney grade) on basis of proliferative activity (mitotic index and/or Ki67 index) necrosis. Building this work, we sought to unify validate internationally scheme for MTC.Tumor tissue...
The CDK4/6 inhibitor palbociclib blocks cell cycle progression in Estrogen receptor-positive, human epidermal growth factor 2 receptor-negative (ER+/HER2-) breast tumor cells. Despite the drug's success improving patient outcomes, a small percentage of cells continues to divide presence palbociclib-a phenomenon we refer as fractional resistance. It is critical understand cellular mechanisms underlying resistance because precise resistant tissue strong predictor clinical outcomes. Here,...
Racial disparities in cancer outcomes are well documented across tumor types. For patients with breast cancer, Black women more likely to present aggressive molecular features and die from disease, even after accounting for those features. Recent efforts have been aimed at developing translational model systems precision medicine strategies, a major focus has on patient-derived organoids. Organoids allow robust vitro experimental platforms, including drug CRISPR screens while maintaining...
Medullary thyroid carcinoma (MTC) is a rare nonfollicular cell-derived tumor. A robust grading system may help better stratify patients at risk for recurrence and death from disease. In total, 144 MTC between 1988 2018 were subjected to detailed histopathologic evaluation. Clinical pathologic data correlated with disease specific survival (DSS), local free (LRFS) distant metastasis (DMFS). Median age was 53 years (range: 3-88). tumor size 1.8 cm 0.2-11). Lymph node metastases present in 84...
Splenectomy is a commonly performed operation; however, data from large series regarding operative outcomes to help guide decision making and informed consent are lacking.To evaluate clinical pathologic variables associated with morbidity mortality following elective splenectomy for benign malignant hematologic conditions in the United States.A review of American College Surgeons National Surgical Quality Improvement Program between January 1, 2005, December 31, 2011, was performed, 1715...
Recent findings suggest that combination treatment with antiestrogen and anti-RET may offer a novel strategy in subset of patients breast cancer. We investigated the role RET potentiating effects response examined whether expression predicted ability for tyrosine kinase inhibitor (TKI) to affect extracellular signal-regulated 1/2 (ERK1/2) activation primary cancer.Growth response, ERK1/2 activation, Ki-67, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling were assessed...
Unresectable tumors of the pancreatic head are encountered in up to 20% patients taken for resection. The objective this study was evaluate complications and outcome associated with palliative surgical procedures help guide management decisions these patients.Patients adenocarcinoma operating room curative intent who did not undergo pancreatectomy were evaluated.From 1997 2013, 50 explored found be unresectable due M1 disease (n = 27, 54.0%) or vascular invasion 23, 46.0%). Among patients,...
Expression of TFAP2C in luminal breast cancer is associated with reduced survival and hormone resistance, partially explained through regulation RET. also regulates EGFR HER2 cancer. We sought to elucidate the functional role used gene knockdown (KD) treatment a tyrosine kinase inhibitor (TKI) cell lines primary isolates determine RET p-ERK tumorigenesis. KD decreased expression panel cancers, chromatin immunoprecipitation sequencing (ChIP-seq) confirmed that targets gene. Stable...
The deubiquitinase USP7 is a critical regulator of tumorigenesis, known for stabilizing the MDM2-p53 pathway. Emerging evidence highlights USP7's p53-independent roles in proliferation and tumorigenesis. Triple negative breast cancers frequently inactivate p53 this disease subtype remains difficult to treat need new therapeutic options. Our study reveals that upregulated TNBC patient tumors. Importantly, genetic pharmacologic inactivation impaired tumor progression models. To explore USP7’s...
Abstract Understanding how individual cancer cells adapt to drug treatment is a fundamental challenge limiting precision medicine therapy strategies. While single-cell technologies have advanced our understanding of cellular heterogeneity, efforts connect the behavior broader tumor responses and uncover global trends across diverse systems remain limited. There growing availability bulk omics data, but lack centralized tools repositories makes it difficult study response globally, especially...
Interpreting the functional impact of genomic variants remains a major challenge in precision oncology, particularly breast cancer, where many unknown significance (VUS) lack clear therapeutic guidance. Current annotation strategies focus on frequent driver mutations, leaving rare or understudied unclassified and clinically uninformative. Here, we present an AI/ML-driven framework that systematically identifies associated with key cancer phenotypes, including ESR1 EZH2 activity, by...
Abstract Endocrine therapy resistance (ETR) remains a formidable challenge in the treatment of estrogen receptor-positive (ER+) luminal breast cancer, frequently leading to therapeutic failure. Our previous research identified transcription factor TFAP2C as key regulator antioxidant enzyme glutathione peroxidase 1 (GPX1), well c-ErbB2/HER2, RET, and EGFR, which lead ERK/MAPK activation promote ETR. Here, we aimed elucidate role redox regulation kinase reprogramming acquired current study...
Abstract Studying tumor evolution has traditionally focused on individual cells gaining fitness advantages to outcompete their neighbors. However, this perspective may miss a crucial aspect of resilience, particularly in cancers driven by extrachromosomal DNA (ecDNA). Rather than evolving at the level, ecDNA-driven operate population scale, where graded variation oncogene copy numbers across enhances adaptability entire cell population. Leveraging single multi-omics sequencing and machine...
We investigated directed therapy based on TFAP2C-regulated pathways to inform new therapeutic approaches for treatment of luminal breast cancer.TFAP2C regulates the expression genes characterizing phenotype including ESR1 and RET, but pathway cross talk potential distinct elements have not been characterized.Activation extracellular signal-regulated kinases (ERK) AKT was assessed using phosphorylation-specific Western blot. Cell proliferation measured with MTT...