A5009297748- Cancer-related molecular mechanisms research
- interferon and immune responses
- RNA modifications and cancer
- Respiratory viral infections research
- Hippo pathway signaling and YAP/TAZ
- Liver Disease Diagnosis and Treatment
- Axon Guidance and Neuronal Signaling
- SARS-CoV-2 and COVID-19 Research
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Immune Response and Inflammation
- Congenital heart defects research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Viral Infections and Vectors
- Immune responses and vaccinations
Ajou University
2024
Institute for Basic Science
2021-2022
The upper respiratory tract is compromised in the early period of COVID-19, but SARS-CoV-2 tropism at cellular level not fully defined. Unlike recent single-cell RNA-Seq analyses indicating uniformly low mRNA expression entry–related host molecules all nasal epithelial cells, we show that protein levels are relatively high and their localizations restricted to apical side multiciliated cells. In addition, provide evidence patients with COVID-19 massively detected replicated within We...
Abstract Stimulator of interferon genes (STING) promotes anti-tumour immunity by linking innate and adaptive immunity, but it remains unclear how intratumoural treatment with STING agonists yields effects. Here we demonstrate that injection the agonist cGAMP induces strong, rapid, selective apoptosis tumour endothelial cells (ECs) in implanted LLC tumour, melanoma breast not spontaneous cancer melanoma. In both tumours, greatly increases TNFα from tumour-associated myeloid cells. However,...
Background and Aims: Metabolic dysfunction–associated steatotic liver disease (MASLD) encompasses a broad continuous spectrum of diseases ranging from fatty to steatohepatitis. The intricate interactions genetic, epigenetic, environmental factors in the development progression MASLD remain elusive. Here, we aimed achieve an integrative understanding genomic transcriptomic alterations throughout MASLD. Approach Results: RNA-Seq profiling (n = 146) whole-exome sequencing 132) tissue samples...
In sprouting angiogenesis, the precise mechanisms underlying how intracellular vascular endothelial growth factor receptor 2 (VEGFR2) signaling is higher in one cell (EC) compared with its neighbor and acquires tip EC phenotype under a similar external cue are elusive. Here, we show that Merlin, encoded by neurofibromatosis type ( NF2 ) gene, suppresses VEGFR2 internalization depending on VE-cadherin density inhibits induction. Accordingly, Nf2 depletion promotes induction excessive...
Intermediate cell carcinoma (Int-CA) is a rare and enigmatic primary liver cancer characterized by uniform tumor cells exhibiting mixed features of both HCC intrahepatic cholangiocarcinoma. Despite the unique pathological int-CA, its molecular characteristics remain unclear yet.
Abstract Thermogenic function of brown adipose tissue (BAT) has beneficial effects in metabolic diseases by utilizing lipids and glucose, whereas inactive BAT accumulates adipocytes (BAs), leading to whitening. Although cellular crosstalk between endothelial cells (ECs) is important for fatty acid uptake adipocytes, the roles ECs de novo lipogenesis (DNL) have been poorly understood. Using single-nucleus RNA sequencing knock-out mice, we demonstrate that stem cell factor (SCF) from promotes...