A5100372671- Retinal Development and Disorders
- Aquaculture disease management and microbiota
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related Molecular Pathways
- Hippo pathway signaling and YAP/TAZ
- Cell death mechanisms and regulation
- Developmental Biology and Gene Regulation
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Retinal Diseases and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Pituitary Gland Disorders and Treatments
- Advanced biosensing and bioanalysis techniques
- Asthma and respiratory diseases
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Axon Guidance and Neuronal Signaling
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Identification and Quantification in Food
- Pancreatic function and diabetes
- Cancer Research and Treatments
- DNA Repair Mechanisms
- RNA Interference and Gene Delivery
- PARP inhibition in cancer therapy
Korea Advanced Institute of Science and Technology
2016-2025
Sun Moon University
2021-2024
Catholic University of Korea
2010-2024
Korea University
2003-2024
Uijeongbu St. Mary's Hospital
2013-2024
Sungkyunkwan University
2000-2024
Yonsei University
2002-2024
Severance Hospital
2024
Hallym University
2024
Wonju Severance Christian Hospital
2012-2024
Abstract The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack appropriate biomarkers have hampered patient prognosis treatment stratification. Recently, we identified that a hepatic stem cell marker, epithelial adhesion molecule (EpCAM), may serve as an early biomarker HCC because its expression is highly elevated in premalignant tissues subset HCC. In this study, aimed to identify novel subtypes resemble certain stages liver lineages by searching for EpCAM-coexpressed...
Abstract The blood–retinal barrier (BRB) consists of tightly interconnected capillary endothelial cells covered with pericytes and glia, but the role in BRB regulation is not fully understood. Here, we show that platelet-derived growth factor (PDGF)-B/PDGF receptor beta (PDGFRβ) signalling critical formation maturation through active recruitment onto growing retinal vessels. Impaired pericyte to vessels shows multiple vascular hallmarks diabetic retinopathy (DR) due disruption. However,...
Although the etiology of Parkinson's disease (PD) remains elusive, recent studies suggest that oxidative stress contributes to cascade leading dopaminergic (DAergic) neurodegeneration. The Nrf2 signaling is main pathway responsible for cellular defense system against stress. a transcription factor regulates environmental response by inducing expression antioxidant enzyme genes. We have synthesized novel vinyl sulfone derivatives. They exhibited broad range activities in HO-1, whose gene...
Nonalcoholic fatty liver disease (NAFLD) is a major risk factor for cancer; therefore, its prevention an important clinical goal. Ablation of phosphatase and tensin homolog (PTEN) or the protein kinase Hippo signaling pathway induces cancer via activation AKT transcriptional regulators YAP/TAZ, respectively; however, potential crosstalk between PTEN/AKT Hippo/YAP/TAZ pathways in tumorigenesis has thus far remained unclear. Here, we have shown that deletion both PTEN SAV1 accelerates...
The SWI/SNF complex is required for the transcription of several genes and has been shown to alter nucleosome structure in an ATP-dependent manner. tumor suppressor protein p53 displays growth transformation suppression functions that are frequently lost mutant proteins detected various cancers. Using genetic biochemical approaches, we show subunits human bind vivo vitro. transactivation function stimulated by overexpression hSNF5 BRG-1 dominant forms repress p53-dependent transcription....
Abstract Hepcidin is a circulating peptide hormone made by the liver that central regulator of systemic iron uptake and recycling. Here, we report prostate epithelial cells also synthesize hepcidin, synthesis secretion hepcidin are markedly increased in cancer tissue. Prostatic functions as an autocrine hormone, decreasing cell surface ferroportin, exporter, increasing intracellular retention, promoting survival. Synthesis controlled unique intersection pathways involves BMP4/7, IL6, Wnt,...
Nanoscale imaging of whole vertebrates is essential for the systematic understanding human diseases, yet this goal has not been achieved. Expansion microscopy (ExM) an attractive option accomplishing aim; however, expansion even mouse embryos at mid- and late-developmental stages, which have fewer calcified body parts than adult mice, to be demonstrated due challenges expanding tissues. Here, we introduce a state-of-the-art ExM technique, termed whole-body ExM, that utilizes cyclic...
The vertebrate retina and optic nerve are strikingly different in terms of their size, organization, cellular diversity, yet these two structures develop from the same embryonic neuroepithelium. Precursor cells most ventral domain this epithelium give rise only to astrocytes nerve, whereas immediately adjacent, more dorsal precursors myriad cell types retina. We provide genetic evidence that closely related, ventrally expressed homeodomain proteins—Vax1 Vax2—control neuroepithelial...
Abstract Background Basic studies of oncogenesis have demonstrated that either the elevated production particular oncogene proteins or occurrence qualitative abnormalities in oncogenes can contribute to neoplastic cellular transformation. The purpose our study was identify an unique gene shows cancer-associated expression, and characterizes its function related human carcinogenesis. Methods We used differential display (DD) RT-PCR method using normal cervical, cervical cancer, metastatic...
Vascular endothelial growth factor (VEGF) signaling is a key pathway for angiogenesis and requires highly coordinated regulation. Although the Notch pathway-mediated suppression of excessive VEGF activity via negative feedback well known, positive control augmenting remains poorly understood. Transcription Sox17 indispensable angiogenesis, but its association with largely unknown. The contribution other Sox members to also be determined.To reveal genetic interaction Sox7, another member, in...
We previously developed a novel series of vinyl sulfones as nuclear factor erythroid 2-related 2 (Nrf2) activators with therapeutic potential for Parkinson's disease (PD). However, the lead compound (1) exhibited undesirable druglike properties. Here, we optimized by introducing nitrogen heterocycles to improve Among synthesized compounds, 17e was most promising drug candidate good Compound showed superior effects on Nrf2 activation in cell-based assays compared 1 (17e: half-maximal...
Abstract The study aims to develop a deep learning based automatic segmentation approach using the UNETR(U-net Transformer) architecture quantify volume of individual thigh muscles(27 muscles in 5 groups) for Sarcopenia assessment. By automating process, this improves efficiency and accuracy muscle calculation, facilitating comprehensive understanding composition its relationship Sarcopenia. utilized dataset 72 whole CT scans from hip fracture patients, annotated by two radiologists. UNETR...
Abstract Purpose: The purpose of our study was to identify an unique gene that shows cancer-associated expression, evaluates its potential usefulness in cancer diagnosis, and characterizes function related human carcinogenesis. Experimental Design: We used the differential display reverse transcription-PCR method with normal cervical, cervical metastatic tissues, cell line genes overexpressed cancers. Results: identified a minichromosome maintenance 3 (MCM3) various cancers, including...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTStructure of Apoptolidin, a Specific Apoptosis Inducer in Transformed CellsYoichi Hayakawa, Jin Woo Kim, Hisashi Adachi, Kazuo Shin-ya, Ken-ichi Fujita, and Haruo SetoView Author Information Institute Molecular Cellular Biosciences The University Tokyo, Bunkyo-ku, Tokyo 113, Japan JEOL Datum Ltd., 3-15-5, Nish-shinjuku Shinjuku-ku, 163, Cite this: J. Am. Chem. Soc. 1998, 120, 14, 3524–3525Publication Date (Web):March 26, 1998Publication...
Coumarins comprise a group of natural phenolic compounds found in variety plant sources. In view the established low toxicity, relative cheapness, presence diet and occurrence various herbal remedies coumarins, it appears prudent to evaluate their properties applications further. The purpose this study is investigate cellular protective activity coumarin compound, fraxin extracted from Weigela florida var. glabbra, under oxidative stress, identify genes expressed differentially by compare...