A5031241864- Glioma Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Cancer, Hypoxia, and Metabolism
- Phytochemicals and Antioxidant Activities
- Cancer Cells and Metastasis
- Natural product bioactivities and synthesis
- melanin and skin pigmentation
- Psychosocial Factors Impacting Youth
- Education and Learning Interventions
- Advanced Wireless Network Optimization
- Food Quality and Safety Studies
- Advanced Wireless Communication Techniques
- Mitochondrial Function and Pathology
- Wireless Communication Networks Research
- Tea Polyphenols and Effects
- Cancer Research and Treatments
- Phytoestrogen effects and research
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Microbial Metabolites in Food Biotechnology
- Silicon and Solar Cell Technologies
- Enzyme Production and Characterization
- 3D Printing in Biomedical Research
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
Catholic University of Korea
2021-2025
Korea Institute of Atmospheric Prediction Systems
2023-2025
Severance Hospital
2016-2024
Yonsei University
2016-2024
Chungbuk National University
2017-2024
Hanyang University
2014-2022
Seoul St. Mary's Hospital
2022
Pohang University of Science and Technology
2021
Eulji University
2019
General Department of Preventive Medicine
2019
Oxidative stresses caused by reactive oxygen species (ROS) can induce rapid depolarization of inner mitochondrial membrane potential and subsequent impairment oxidative phosphorylation. Damaged mitochondria produce more ROS, especially the superoxide anion (O2−) hydrogen peroxide (H2O2), which potentiate mitochondria-driven ROS propagation, so-called ROS-induced release (RIRR), via activation an inter-mitochondria signaling network. Therefore, loss function in only a fraction might...
Epigallocatechin gallate (EGCG) is a catechin and an abundant polyphenol in green tea. Although several papers have evaluated EGCG as cosmetic constituent, the skin hydration effect of poorly understood. We aimed to investigate mechanism by which promotes measuring hyaluronic acid synthase (HAS) hyaluronidase (HYAL) gene expression antioxidant anti-pigmentation properties using cell proliferation assay, Western blotting analysis, luciferase 2,2-diphenyl-1-picrylhydrazyl (DPPH) reverse...
Glioblastoma multiforme (GBM) is the most common brain tumor with very aggressive and infiltrative. Extracellular matrix (ECM) plays pivotal roles in infiltrative characteristics of GBM. To understand invasive characteristic GBM, it necessary to study cell-ECM interaction physiologically relevant biomimetic model that recapitulates GBM-specific ECM microenvironment. Here, we propose microenvironment for studying mode dynamics glioblastoma cell invasion. Using tissue decellularization...
BIOGF1K, a compound K-rich fraction prepared from the root of Panax ginseng, is widely used for cosmetic purposes in Korea. We investigated functional mechanisms anti-inflammatory and antioxidative activities BIOGF1K by discovering target enzymes through various molecular studies.We explored inhibitory using lipopolysaccharide-mediated inflammatory responses, reporter gene assays involving overexpression toll-like receptor adaptor molecules, immunoblotting analysis....
Abstract Background Although meningioma is the most common primary brain tumor, treatments rely on surgery and radiotherapy, recurrent meningiomas have no standard therapeutic options due to a lack of clinically relevant research models. Current cell lines or organoids cannot reflect biological features patient tumors since they undergo transformation along culture consist only tumor cells without microenvironment. We aim establish patient-derived (MNOs) preserving diverse types...
Loss of contractility and acquisition an epithelial phenotype vascular smooth muscle cells (VSMCs) are key events in proliferative pathologies such as atherosclerosis post-angioplastic restenosis. There is no proper cell culture system allowing differentiation VSMCs so that it difficult to delineate the molecular mechanism responsible for vasculopathy. We investigated whether a micropatterned substrate could restore contractile vitro. To induce maintain differentiated VSMC vitro, we...
Compound K (CK) is a ginsenoside, metabolite of Panax ginseng. There interest both in increasing skin health and antiaging using natural care products. In this study, we explored the possibility CK as cosmetic ingredient. To assess effect CK, RT-PCR was performed, expression levels matrix metalloproteinase-1, cyclooxygenase-2, type I collagen were measured under UVB irradiation conditions. The hydrating tested by RT-PCR, its regulation through immunoblotting. Melanin content, melanin...
Vascular endothelial growth factor (VEGF) signaling is a key pathway for angiogenesis and requires highly coordinated regulation. Although the Notch pathway-mediated suppression of excessive VEGF activity via negative feedback well known, positive control augmenting remains poorly understood. Transcription Sox17 indispensable angiogenesis, but its association with largely unknown. The contribution other Sox members to also be determined.To reveal genetic interaction Sox7, another member, in...
Targeted approaches for treating glioblastoma (GBM) attempted to date have consistently failed, highlighting the imperative treatment strategies that operate on different mechanistic principles. Bioenergetics deprivation has emerged as an effective therapeutic approach various tumors. We previously found cancer cells preferentially utilize cytosolic NADH supplied by aldehyde dehydrogenase (ALDH) ATP production through oxidative phosphorylation (OxPhos). This study is aimed at examining...
Deprivation of tumor bioenergetics by inhibition multiple energy pathways has been suggested as an effective therapeutic approach for various human tumors. However, this idea not evaluated in glioblastoma (GBM). We hypothesized that dual glycolysis and oxidative phosphorylation could effectively suppress GBM tumorspheres (TS). Effects 2-deoxyglucose (2DG) metformin, alone combination, on GBM-TS were evaluated. Viability, cellular metabolism status, stemness, invasive properties,...
Background: Although programmed death-1 (PD-1) blockade is effective in treating several types of cancer, the efficacy this agent glioblastoma (GBM) largely unknown.Methods: We evaluated therapeutic effects anti-PD-1, temozolomide (TMZ), and their combination an orthotopic murine GBM model. The phenotype, number, composition lymphocytes were using flow cytometry. Transcriptional profiles tumor tissues analyzed microarrays. Generation antitumor immunological memory was investigated upon...
Abstract Glioblastoma multiforme (GBM), a deadly cancer, is the most lethal and common malignant brain tumor, leading cause of death in adult tumors. While genomic data continues to rocket, clinical application translation patient care are lagging behind. Big now deposited TCGA network offers window generate novel hypotheses. We hypothesized that TCGA-derived gene-classifier can be applied across different gene profiling platforms population groups. This validated three robust GBM-subtypes...
Abstract Introduction The importance of fatty acid oxidation (FAO) in the bioenergetics glioblastoma (GBM) is being realized. Etomoxir (ETO), a carnitine palmitoyltransferase 1 (CPT1) inhibitor exerts cytotoxic effects GBM, which involve interrupting FAO pathway. We hypothesized that inhibition could affect outcomes current standard temozolomide (TMZ) chemotherapy against GBM. Methods FAO-related gene expression was compared between GBM and tumor-free cortex. Using four different...
Hepatitis C virus (HCV) infection results in liver injury and long-term complications, such as cirrhosis hepatocellular carcinoma. Liver HCV is believed to be caused by host immune responses, not viral cytopathic effects. Tumor necrosis factor-alpha (TNF-α) plays a pivotal role the inflammatory processes of hepatitis C. TNF-α induces cell death that can ameliorated nuclear factor kappaB (NF-κB) activation. We investigated regulation signal transduction HCV-infected cells identified proteins...
BIOGF1K, a compound-K-rich fraction, has been shown to display anti-inflammatory activity. Although Panax ginseng is widely used for the prevention of photoaging events induced by UVB irradiation, effect BIOGF1K on not yet examined. In this study, we investigated effects UVB-induced events. We analyzed ability prevent apoptosis, enhance matrix metalloproteinase (MMP) expression, upregulate activity, reduce sirtuin 1 and melanin production using reverse transcription-polymerase chain...
Abstract Background Despite advancements in targeted therapy and immunotherapy, cutaneous melanoma continues to have a high mortality rate poor prognosis, with therapies having limited efficacy advanced melanoma. Therefore, it is crucial develop novel therapeutics proven clinical potential. In this study, we evaluated the of arcyriaflavin A (ArcA), potent inhibitor cyclin D1/CDK4 complex, suppressing aggressive phenotypes metastatic Methods The effects ArcA on viability cell cycle were...
// Junjeong Choi 1, 2, * , Ji-Hyun Lee 3, Ilkyoo Koh 4, Jin-Kyoung Shim 3 Junseong Park Jeong Yong Jeon 5 Mijin Yun Se Hoon Kim 6 Jong In Yook 7 Eui Hyun Hee Chang Sun Ho Min Huh 8 Su Jae 9 Michael Pollak 10 Pilnam 4 Seok-Gu Kang Jae-Ho Cheong 11 1 Department of Pharmacy, College Yonsei Institute Pharmaceutical Sciences, University, Incheon, Republic Korea 2 Brain 21 Plus Project for Medical Science, Seoul, Departments Neurosurgery, Tumor Center, Severance Hospital, University Medicine, Bio...