A5100771883- Diverse Approaches in Healthcare and Education Studies
- Reproductive Biology and Fertility
- Educational Systems and Policies
- Technology and Data Analysis
- Pluripotent Stem Cells Research
- Renal and related cancers
- Sperm and Testicular Function
- Animal Genetics and Reproduction
- Diverse Topics in Contemporary Research
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Connexins and lens biology
- Virus-based gene therapy research
- Xenotransplantation and immune response
- Reproductive System and Pregnancy
- Estrogen and related hormone effects
- Marine and Coastal Research
- Ovarian function and disorders
- CRISPR and Genetic Engineering
- Healthcare and Venom Research
- Education, Safety, and Science Studies
- Yersinia bacterium, plague, ectoparasites research
- Prenatal Screening and Diagnostics
- Ion Transport and Channel Regulation
Yonsei University
2018-2025
Dalhousie University
2024
Pukyong National University
2024
Chungbuk National University
2013-2024
Chungnam National University
2013-2023
Hebei University of Engineering
2023
Korea University Medical Center
2023
Yonsei University College of Dentistry
2022
Jackson State University
2017-2022
Western University
2018-2020
Background: Although programmed death-1 (PD-1) blockade is effective in treating several types of cancer, the efficacy this agent glioblastoma (GBM) largely unknown.Methods: We evaluated therapeutic effects anti-PD-1, temozolomide (TMZ), and their combination an orthotopic murine GBM model. The phenotype, number, composition lymphocytes were using flow cytometry. Transcriptional profiles tumor tissues analyzed microarrays. Generation antitumor immunological memory was investigated upon...
Abstract Poor‐quality oocytes (those with 1–2 layers of cumulus cells) typically possess low meiotic competence and development. Prolonging the duration in vitro maturation (IVM; 52 hr) can enhance rate poor‐quality oocytes, but it does not improve subsequent embryonic This likely reflects increased reactive oxygen species (ROS) production apoptosis seen these compared non‐prolonged IVM (44 group. Melatonin is a free radical scavenger, anti‐oxidant anti‐apoptotic agent that reported to...
The zebrafish model is an attractive candidate for screening of developmental toxicity during early drug development. Antiepileptic drugs (AEDs) arouse concern the risk teratogenicity, but data are limited. In this study, we evaluated teratogenic potential seven AEDs (carbamazepine (CBZ), ethosuximide (ETX), valproic acid (VPN), lamotrigine (LMT), lacosamide (LCM), levetiracetam (LVT), and topiramate (TPM)) in model. Zebrafish embryos were exposed to from initiation gastrula (5.25 hours...
SUMMARY Lysophosphatidic acid (LPA), a member of the phospholipid autacoid family, is present in human follicular fluid. The aim study was to compare developmental competence porcine embryos created via vitro fertilization (IVF) and parthenogenetic activation (PA) culture medium supplemented with LPA, comparison control group. effects LPA on oocyte maturation pre‐implantation embryonic development were also examined. Addition 10 μM significantly increased proportion oocytes reaching...
Abstract Background: Adenocarcinoma (ADCA) is a type of cancer that originates in glandular epithelial cells various organs such as pancreas, colon and lung. Spatial transcriptomics enables the high-resolution mapping gene expression within tumor microenvironment, preserving spatial context. This allows for identification tumor-specific targets context complex providing insights critical precision oncology. Through data-driven target discovery platform which leverages large scale...
The mRNA processing and export factor, Iws1, interacts with the histone H3/H4 chaperone, Spt6 (Supt6 in mouse gene ontology) recruits lysine methyltransferase, Setd2, to chromatin regulate H3K36me3. This recruitment is known be crucial for pre-mRNA splicing Iws1 has been shown interact REF1/Aly mediate export. However, role of this complex not yet examined embryonic development. Here, we show that knockdown either or Supt6 blocked embryo development, primarily at 8/16-cell stage, indicating...
Two dimensional-fluorescence difference gel electrophoresis (2D DIGE) is an emerging technique for comparative proteomics, which improves the reproducibility and reliability of differential protein expression analysis between samples. The purpose this study was to investigate bovine pregnancy-specific proteins in proteome pregnant non-pregnant serum using DIGE technique. Serums 2 Holstein dairy cattle at day 21 after artificial insemination those were used study. pre-electrophoretic labeling...
Chronic kidney disease (CKD) is a major non-communicable associated with high rates of premature morbidity and mortality. The prevalence hypovitaminosis D (deficiency 25(OH)D or 25D) greater in racial/ethnic minorities patients CKD than the general population. Low 25D bone mineral disorders as well immune, cardiometabolic cardiovascular (CV) diseases. Thus, it has been suggested that low contributes to poor outcomes CKD. rises progressively advancing severity over 30% stage 3 70% 5 estimated...
Objective During stimulated IVF cycles, up to 15% of oocytes are recovered as immature. The purpose this study was investigate the trend oocyte maturity in repeated ovarian stimulation for IVF. Methods One hundred forty-eight patients were selected who underwent two consecutive cycles using same protocol during 2008 2010. Ovarian performed with FSH and human menopausal gonadotropin flexible GnRH antagonist both cycles. Oocyte assessed according presence germinal vesicle (GV) first polar...
Objectives : The purpose of this study is to examine the effects a 3 day Hwa-Byung forests healing program, which consists helpful contents Korean medicine. Methods This examined for patients, visited medicine hospital neuropsychiatry clinic outpatients. program was run with 20 participants; 4 them quit in middle and excluded data analysis. consisted contents. primary outcome measurement symptom score, measured various symptoms Hwa-Byung. Results results showed that were significantly...
Objective In 2009 anti-Müllerian hormone (AMH) assay was approved for clinical use in Korea. This study performed to determine the reference values of AMH predicting ovarian response controlled hyperstimulation (COH) using data. Methods One hundred sixty-two women who underwent COH cycles were included this study. We collected data on age, basal and FSH levels, total dose gonadotropins, stimulation duration, numbers oocytes retrieved fertilized. Blood samples obtained cycle day 3 before...
Mesenchymal stromal cells (MSCs) are multipotent progenitor that originally derived from bone marrow. Clinical use of marrow-derived MSC is difficult due to morbidity and low abundance isolation efficiency. Recently, MSCs have been isolated various adult tissues. Here we report the adenoid tissue-derived (A-MSCs) their characteristics.We compared surface markers, morphologies, differentiation proliferation capacities previously established tonsil-derived (T-MSCs) (BM-MSCs) with tissue. The...