A5091433891- Gene Regulatory Network Analysis
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Blood Pressure and Hypertension Studies
- Vitamin D Research Studies
- Dialysis and Renal Disease Management
- Computational Drug Discovery Methods
- Chronic Kidney Disease and Diabetes
- COVID-19 Clinical Research Studies
- Microbial Metabolic Engineering and Bioproduction
- Algorithms and Data Compression
- Evolutionary Algorithms and Applications
- Malaria Research and Control
- Security in Wireless Sensor Networks
- Energy Efficient Wireless Sensor Networks
- Invertebrate Immune Response Mechanisms
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Mobile Ad Hoc Networks
- Health Sciences Research and Education
- Nutritional Studies and Diet
- Vitamin C and Antioxidants Research
- Pharmaceutical Practices and Patient Outcomes
- Bone health and osteoporosis research
- Birth, Development, and Health
Universidade Federal do ABC
2015-2024
Charles R. Drew University of Medicine and Science
2008-2022
University of California, Los Angeles
2000-2018
École Nationale Supérieure d'Art
2011
Université de franche-comté
2009-2010
Franche-Comté Électronique Mécanique Thermique et Optique - Sciences et Technologies
2010
Universidade de São Paulo
2005-2009
Laboratoire d'Informatique de Paris-Nord
2005-2009
Czech Academy of Sciences, Institute of Mathematics
2009
Institute of Mathematics and Informatics
2009
Results of several epidemiologic and clinical studies have suggested that there is an excess risk hypertension diabetes mellitus in persons with suboptimal intake vitamin D.We examined the association between serum levels 25-hydroxyvitamin D (25[OH]D) select cardiovascular disease factors US adults. A secondary analysis was performed data from Third National Health Nutrition Examination Survey, a national probability survey conducted by Center for Statistics January 1, 1988, December 31,...
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019; COVID-19) is associated with adverse outcomes in patients cardiovascular (CVD). The aim of the study was to characterize interaction between SARS-CoV-2 and Angiotensin-Converting Enzyme (ACE2) functional networks a focus on CVD. Methods: Using network medicine approach publicly available datasets, we investigated ACE2 tissue expression described that could be affected by heart, lungs...
To investigate differences in overweight and obesity between first-generation Dutch-Ghanaian migrants The Netherlands their rural urban counterparts Ghana.Cross-sectional study.A total of 1471 Ghanaians (rural Ghanaians, n 532; 787; Dutch-Ghanaians, 152) aged > or = 17 years.Overweight (BMI 25 kg/m2) 30 kg/m2).Dutch-Ghanaians had a significantly higher prevalence (men 69.1%, women 79.5%) than 22.0%, 50.0%) 10.3%, 19.0%). Urban Ghanaian men also counterparts. In logistic regression analysis...
Wireless sensor networks are specific adhoc networks. They characterized by their limited computing power and energy constraints. This paper proposes a study of security in this kind network. We show what the specificities vulnerabilities wireless present list attacks, which can be found these particular networks, how they use vulnerabilities. Finally we discuss about different solutions made scientific community to secure
Despite concerns about racial differences on adherence to prescribed medication rigimens among older adults, current information nonadherence underserved elderly African Americans with co-morbidities is limited. This study examines the association between drug regimens and an array of medication-related factors, including polypharmacy, regimen complexity, use Potentially Inappropriate Medications (PIM), knowledge therapeutic purpose instructions use. Four-hundred Americans, aged 65 years...
Compassion is the capacity for being moved by suffering of others and wanting to help alleviate it. may mediate health benefits hazards social networks/relationships. The monitoring/management level compassion across networks/relationships be critical benefits’ preservation networks/relationships’ prevention. We developed evaluated psychometric properties 10-item self-report measure among 310 respondents from University surrounding communities. mean total score was 3.62 (SD=1.09)....
African Americans have higher rates of nocturnal hypertension and less blood pressure (BP) dipping compared with whites. Although is associated increased cardiovascular morbidity mortality, its clinical significance among those normal daytime BP unclear. This paper reports the prevalence correlates isolated (INH) in a population-based cohort enrolled Jackson Heart Study (JHS).The study sample included 425 untreated, normotensive hypertensive JHS participants who underwent 24-hour ambulatory...
Molecular data generation and their combination in penile carcinomas (PeCa), a significant public health problem poor underdeveloped countries, remain virtually unexplored. An integrativemethodology combin ing genome-wide copy number alteration, DNA methylation, miRNA mRNA expression analysis was performed set of 20 usual PeCa. The well-ranked 16 driver candidates harboring genomic alterations regulated by miRNAs, including hsa-miR-31, hsa-miR-34a hsa-miR-130b, were significantly associated...
SARS-CoV-2 tropism for the ACE2 receptor, along with multifaceted inflammatory reaction, is likely to drive generalized hypercoagulable and thrombotic state seen in patients COVID-19. Using original bioinformatic workflow network medicine approaches we reanalysed four coronavirus-related expression datasets performed co-expression analysis focused on thrombosis related genes. We identified microRNAs (miRNAs) which play role ACE2-related coronavirus infection further, validated expressions of...
Available techniques for monitoring the health situation have proven insufficient, thus leading to a discussion of need their improvement based on new data collection strategies allowing use by local systems. This article presents methodological basis strategy monitor problems utilizing demarcated intra-urban spaces called "sentinel areas" collect fundamental social, economic, behavioral, and biological public that allow closer approach reality complex social spaces. The authors present an...
Feature selection is a pattern recognition approach to choose important variables according some criteria in order distinguish or explain certain phenomena (i.e., for dimensionality reduction). There are many genomic and proteomic applications that rely on feature answer questions such as selecting signature genes which informative about biological state, e.g., normal tissues several types of cancer; inferring prediction network among elements genes, proteins external stimuli. In these...
Background: Vitamin D deficiency has been implicated as a potential risk factor for cardiovascular disease. The high rate of vitamin ( 25) African Americans with elevated blood pressure (130 - 150/85 100 mmHg) and low serum level (10 25 ng/ml). Results: There was significant increase in the 25(OH)D levels to mean 34.5 ng/ml (SD = 7.1) intervention (p < 0.001). associated decrease intact PTH 0.02), urinary isoprostane 0.02) adipocyte cytokine expression. Although not any change Pulse Wave...
Canalizing genes possess such broad regulatory power, and their action sweeps across a wide swath of processes that the full set affected are not highly correlated under normal conditions. When active, controlling gene will be predictable to any significant degree by its subject genes, either alone or in groups, since behavior varied relative inactive gene. is well predicted one targets, but can very groups control. To investigate this question, we introduce paper concept intrinsically...
Older African Americans who experience pain are especially at high risk of underassessment and undertreatment. This study examined patterns correlates medication use: severity pain, medical conditions, access to care. aged 65 older were recruited from 16 churches located in south Los Angeles (N = 400). Structured face‐to‐face interviews visual inspection each participant's medications conducted. More than 39% participants 75 older, 65% female. Forty‐seven percent used least one type...
Psychiatric disorders involve both changes in multiple genes as well different types of variations. As such, gene co-expression networks allowed the comparison stages and parts brain contributing to an integrated view genetic variation. Two methods based on presents appealing results: Weighted Gene Correlation Network Analysis (WGCNA) Network-Medicine Relative Importance (NERI). By selecting two expression databases related schizophrenia, we evaluated biological modules selected by WGCNA...