A5047419607- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Extracellular vesicles in disease
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Blood disorders and treatments
- Polyomavirus and related diseases
- Autoimmune and Inflammatory Disorders Research
- MicroRNA in disease regulation
- Viral-associated cancers and disorders
- Vascular Anomalies and Treatments
- Circular RNAs in diseases
- Urticaria and Related Conditions
- Xenotransplantation and immune response
- Dermatological and COVID-19 studies
- COVID-19 diagnosis using AI
- Lymphoma Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Cardiovascular Disease and Adiposity
- Herpesvirus Infections and Treatments
- Immunotherapy and Immune Responses
- Congenital Ear and Nasal Anomalies
- Renal Diseases and Glomerulopathies
Medical University of Warsaw
2006-2024
Central Clinical Hospital
2019-2023
Wojskowy Instytut Medycyny Lotniczej
2021
Instytut Hematologii i Transfuzjologi
2005-2006
SARS-CoV-2 tropism for the ACE2 receptor, along with multifaceted inflammatory reaction, is likely to drive generalized hypercoagulable and thrombotic state seen in patients COVID-19. Using original bioinformatic workflow network medicine approaches we reanalysed four coronavirus-related expression datasets performed co-expression analysis focused on thrombosis related genes. We identified microRNAs (miRNAs) which play role ACE2-related coronavirus infection further, validated expressions of...
Silver-based materials are widely used in clinical medicine. Furthermore, the usage of silver containing and devices is recommended clinically approved. The impact on human health increasing use nanoparticles medical remains understudied, even though Ag-containing dressings known to release into bloodstream. In this study, we detected a widespread sometimes significant accumulation both healthy sick liver biopsies, levels being statistically higher patients with various hepatic pathologies....
Abstract Angiotensin converting enzyme 2 (ACE2) serves as the primary receptor for SARS-CoV-2 virus and has implications functioning of cardiovascular system. Based on our previously published bioinformatic analysis, in this study we aimed to analyze diagnostic predictive utility miRNAs (miR-10b-5p, miR-124-3p, miR-200b-3p, miR-26b-5p, miR-302c-5p) identified top regulators ACE2 network with potential affect cardiomyocytes system patients COVID-19. The expression was determined through...
Most patients with primary immune deficiency suffer from recurrent infections; however, paradoxical autoimmune phenomena can also manifest. The aim of this study was to identify immunological markers associated common variable immunodeficiency (CVID). included 33 adults CVID divided into two groups: (1) those noninfectious complications (CVID-C (
Facilitated subcutaneous immunoglobulin (fSCIG) replacement therapy is the latest method of IgG administration; however, real-life data are limited. We analyzed everyday aspects fSCIG administration, particularly, used to switch from intravenous (IVIG) or (SCIG) and dosing modifications required. Of 39 adult patients with primary immunodeficiency (PID) who received fSCIG, 34 remained on at end study. The mean observation time was 18.27 (range, 6–24) months. Two were IgG-treatment-naïve; 23...
Introduction Primary immunodeficiencies (PIDs) are clinically heterogeneous disorders caused by abnormalities in the immune system. However, PIDs genetically determined and may occur at any age from early childhood to elderly age. Due chronic patterns, risk of malignancy organ damage patients with affect aspect life, including sleep patterns. To our knowledge, prevalence insomnia subjective quality have not been investigated PIDs. Therefore, this pilot study was conducted investigate...
AMA Roszczyk A, Zych M, Sołdacki D, Zagozdzon R, Kniotek M. Reference values of lymphocyte subsets from healthy Polish adults. Central European Journal Immunology. 2024. doi:10.5114/ceji.2024.136371. APA Roszczyk, A., Zych, M., Sołdacki, D., Zagozdzon, R., & Kniotek, (2024). https://doi.org/10.5114/ceji.2024.136371 Chicago Aleksander, Michał Dariusz Radoslaw and Monika J. Kniotek. "Reference adults". Harvard MLA Aleksander et al. adults." Immunology, Vancouver
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) belongs to systemic autoinflammatory diseases (AIDs). Many of these syndromes are genetically conditioned and can be inherited. Diagnosis relies on clinical symptoms should confirmed by genetic testing. One the most serious complications is AA amyloidosis. We present diagnostic route a 33-year-old male with amyloidosis his children, leading diagnosis monogenic syndrome, analysis. A novel variant in-frame insertion type in...
Rationale: Relapsing polychondritis (RP) is a multisystemic, progressive disease of unknown etiology characterized by recurrent inflammation and cartilage destruction. It can involve all types including ears nose, tracheobronchial tree, joints, any other tissue rich in proteoglycans such as heart, eyes, blood vessels. Recurrent chondritis be life-threatening if the respiratory tract, heart valves, or vessels are affected. To date there no data literature on post solid organ transplantation...
<h3>Background</h3> Autoinflammatory diseases (AIDs) cover a spectrum of diseases, which lead to chronic or recurrent inflammation caused by activation the innate immune system, typically in absence high titre autoantibodies.<sup>1</sup> The most common monogenic AIDs are cryopyrin-associated periodic syndromes (CAPS), familial Mediterranean fever (FMF) and tumour necrosis factor receptor-associated syndrome (TRAPS). In hereditary AIDs, can both acute disease irreversible damage.<sup>2</sup>...
<b>Abstract ID 19272</b> <b>Poster Board 307</b> COVID-19 is associated with an increased risk of mortality and adverse cardiovascular (CV) occurrences. ACE2 interaction network caused by virus infection can affect the expression levels miRNAs influence severity disease. This study aimed to analyse diagnostic/predictive utility ACE2-related miRNAs, which were identified in silico analysis (miR-10b-5p, miR-124-3p, miR-200b-3p, miR-26b-5p, miR-302c-5p) patients COVID-19, unravel functions...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): Medical University Warsaw and São Paulo Research Foundation (FAPESP). Introduction Coronavirus disease 2019 (COVID-19) is associated with an increased risk mortality adverse cardiovascular (CV) occurrences, especially in a group patients CV diseases (CVD). SARS-CoV-2 virus enters cells through angiotensin converting enzyme 2 (ACE2) cell membrane enzymes, leading to the...
ACE2 interaction network caused by virus infection can affect the expression levels of miRNAs and influence severity COVID19. This study aimed to analyse diagnostic/predictive utility ACE2-related miRNAs, identified in silico analysis: miR10b, miR124, miR200b-3p, miR26b, miR302c-5p patients with COVID-19, unravel functions using machine learning-SHAP analysis for clinical data bioinformatic tools. Blood samples 79 32 healthy were collected at; day admission, 7days 21days after admission....