A5011014154- Immunodeficiency and Autoimmune Disorders
- Systemic Sclerosis and Related Diseases
- Salivary Gland Disorders and Functions
- Blood disorders and treatments
- Vasculitis and related conditions
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Blood groups and transfusion
- Respiratory viral infections research
- Nutrition and Health in Aging
- Dermatology and Skin Diseases
- Pediatric health and respiratory diseases
- Chronic Lymphocytic Leukemia Research
- Otitis Media and Relapsing Polychondritis
- Dialysis and Renal Disease Management
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Organ Donation and Transplantation
- Inflammatory Myopathies and Dermatomyositis
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Kidney Disease and Diabetes
- Renal Transplantation Outcomes and Treatments
- Paraoxonase enzyme and polymorphisms
- Lymphatic System and Diseases
- Lipid metabolism and disorders
- Biochemical Acid Research Studies
Gdańsk Medical University
2012-2025
Tissue Gene (United States)
2010
Changes mediated by oxidative stress are thought to be involved with atherosclerosis in patients chronic kidney disease (CKD). The purpose of this study was analyze the markers damage and activity antioxidative enzymes as well total antioxidant capability different stages CKD, both conventionally treated dialyzed. We evaluated modification lipids (by oxidized low-density lipoprotein malonodialdehyde levels) proteins advanced oxidation protein products level). also assessed paraoxonase-1...
Recent years brought considerable attention to the connection between chronic stress and development of autoimmune diseases. However, little is still known about impact prolonged reactions on onset course primary Sjögren Syndrome (pSS). This study aimed seek for associations stress, resulting from stressful life events, pSS. In study, 50 patients with diagnosed pSS, as well control osteoarthritis underwent an assessment. Modified Holmes-Rahe (H-R) scale was used in order evaluate events...
Abstract Objectives Sjögren's syndrome (SS) is a chronic inflammatory disease with an autoimmune background possible complications from peripheral (PNS) and central nervous system (CNS). The aim of this study was to assess the prevalence describe phenotype neuropathies in patients SS. Materials & Methods We studied fifty primary for involvement. All underwent neurological rheumatological examination followed by nerve conduction studies (NCS) nine nerves. Results Thirty‐six (72%)...
Inhibition of the renin-angiotensin-aldosterone system (RAAS) with angiotensin converting enzyme inhibitors (ACEI) and/or II subtype 1 receptor antagonists (ARB) is a common strategy used in management patients chronic kidney disease (CKD). However, there no universal therapy that can stop progression CKD. Pentoxifylline (PTE) non-specific phosphodiesterase inhibitor anti-inflammatory properties. It has been reported to have promising effects CKD treatment.In placebo-controlled, randomized,...
At the beginning of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic, patients with inborn errors immunity (IEI) appeared to be particularly vulnerable a severe course disease. It quickly turned out that only some IEI groups are associated high risk infection. However, data on Disease 2019 (COVID-19) in still insufficient, especially children; hence, further analyses required. The retrospective study included 155 unvaccinated people IEI: 105 children and 50 adults (67.7%...
Background. Chronic renal failure is a disease of the elderly. The elderly are fastest growing population among dialysis patients and also on waiting lists for kidney transplantation. objective this study was to analyze results transplantation in recipients elder than 60 years. To minimize donor variability bias, paired analysis used. Methods. older (ORT) group included 44 (30 men, 14 women) aged 72 (mean 64±3) Their pairs created younger (YRT) consisting 59 40±12) Results. Graft function...
Abstract Sjögren’s syndrome (SS) is a chronic autoimmune disease with wide spectrum of possible organ involvement. Peripheral (PNS) and central nervous system (CNS)-related symptoms may occur in the course disease. The aim this study was to compare health-related quality life (HR-QOL) SS patients without peripheral neuropathy. involved 50 primary (pSS). All underwent neurological clinical examination followed by nerve conduction studies (NCS) rheumatological examination. Thirty-six-item...
The life expectancy and the risk of developing cardiovascular diseases in patients with inborn errors immunity are systematically increasing. aim study was to assess factors evaluate heart echocardiography primary antibody deficiency (PAD). Cardiac echography selected factors, including body mass index, sedentary lifestyle, nicotine, glucose, C-reactive protein, lipid profile, uric acid level, certain chronic diseases, glucocorticoid use, were analyzed 94 >18 years age PAD. Of...
(1) Background: Impaired nutritional status in systemic sclerosis (SSc) is prevalent. (2) Objective: This study aimed to identify pre-cachexia and malnutrition SSc patients estimate the effectiveness of a high-protein oral supplement (ONS) improving their status. (3) Materials methods: The population comprised 56 control group 49 healthy persons. After baseline clinical evaluation, bioelectrical impedance analysis (BIA), laboratory tests, were divided into well-nourished, pre-cachectic,...
An improved recognition of inborn errors immunity (IEI) is associated with an increase in life expectancy and a higher incidence complications related conditions. The aim the study was to analyze factors enabling primary prevention: BMI, smoking selected laboratory tests (morphology smear, creatinine, eGFR, total protein, albumin, ferritin, folic acid, vitamin B12, D3) included protocols standard care for adult patients antibody deficiencies (PADs). 94 participants ≥ 18 years old, diagnosed...
Common variable immunodeficiency (CVID) is the most clinically significant primary antibody recognized in adulthood. Previously published data have shown a diagnostic delay of up to an average 10 years for Polish adult patients with CVID. In current study, we aimed analyze CVID Poland. To this end, identified from four immunological centers specializing care immunodeficiencies (PID). Demographic and clinical were collected using internet database. We 103 (F:M 44.7%:55.3%) Poland The median...
Introduction Primary immunodeficiencies (PIDs) are clinically heterogeneous disorders caused by abnormalities in the immune system. However, PIDs genetically determined and may occur at any age from early childhood to elderly age. Due chronic patterns, risk of malignancy organ damage patients with affect aspect life, including sleep patterns. To our knowledge, prevalence insomnia subjective quality have not been investigated PIDs. Therefore, this pilot study was conducted investigate...
Antineutrophil cytoplasmic antibody-associated vasculitides (AAV) are a group of autoimmune diseases characterized by inflammation small blood vessels. Smoking is potential trigger for such diseases, however, its link with AAV remains controversial.The aim this study was to analyze the between and smoking based on clinical characteristics, disease activity, mortality.This retrospective included 223 patients. Their status assessed at diagnosis they were classified as ever smokers (ESs),...
There is evidence that dyslipidemia associated with chronic kidney disease (CKD) and it has been implicated in the progression of renal damage. Optimal management should therefore lead to benefits. A number experimental models demonstrate a beneficial effect statins ameliorating However, exact mechanism by which protect against damage remains unclear.In placebo-controlled, randomized, cross-over study we evaluated influence atorvastatin (ATO) 40 mg/day added renin-angiotensin-aldosterone...
Introduction The COVID-19 pandemic has changed many aspects of everyday life. Patients with primary immunodeficiency (PID) are in a particularly difficult situation. purpose the present study was to contribute very limited research on functioning PID patients during pandemic. Methods survey included 85 adult treated immunoglobulin replacement therapy four reference centers for immunology. Everyday as well their opinion concerning new solutions medical care were analyzed. Results During...
The majority of primary immunodeficiencies (PIDs) are antibody deficiencies (PADs), and not all them rare diseases; As an example, Caucasian individuals suffer from selective IgA deficiency at a frequency 1:500. In addition to infections, symptomatic patients with PAD more likely develop neoplastic, autoimmune, allergic diseases. the event that is neglected or delayed for than ten years, complications develop, eventually resulting in death. No studies have been conducted devise report...
Data regarding the willingness of patients affected by inborn errors immunity to accept vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited. Therefore, this study assessed SARS-CoV-2 coverage and hesitancy in immunodeficient surveying adults with primary immune deficiencies autoinflammatory rheumatic diseases on biologic therapy. The was conducted from September 20, 2021, January 22, 2022, when disease 2019 (COVID-19) vaccinations were...
Owing to the rising popularity and demand for immunoglobulins (IgG), obtaining supplies rationalizing IgG use have become challenging. Herein, consumption in Poland was analyzed through total number of patients reported National Health Fund between 1 January 2016 31 December 2020. Total used within 5 years increased by 27.48%, use/1000 inhabitants/year 23.13 g (2016) 29.61 (2020). In 2020, 35.5 % neurological conditions, 25% primary immunodeficiencies (PID), 39.3% all other indications....
<h3>Background</h3> Patients with systemic sclerosis (SSc) are at risk of malnutrition, which ranges from 18% to 56% cases.<sup>1,2</sup> The high impact nutritional status on clinical outcome has been shown for many diseases. optimal treatment can lead improvement or preservation the current and increases probability long-term survival.<sup>3</sup> <h3>Objectives</h3> aim study was determine whether support an in SSc patients. <h3>Methods</h3> included 61 patients 49 healthy adults....
The dynamic development of clinical immunology in Europe began mid 1980s, and was continued Poland shortly thereafter. In 1993 the first national consultant field appointed Poland. A milestone establishment Polish Working Group for Primary Immunodeficiencies (PGR PID) 2005. Since then, a network numerous paediatric internal medicine centres has been created within Group, facing resolving new challenges field. study presents organization care patients with primary secondary immunodeficiencies...
Common variable immunodeficiency (CVID) is a primary disorder characterized by decreased or undetectable serum levels of immunoglobulin G (IgG), IgA isotypes, and poor specific antibody production in response to vaccines pathogens. Owing hypogammaglobulinemia, patients have increased susceptibility infections higher risk malignancies. Here we present case study patient with diagnosis CVID, who refused replacement therapy despite plenty complications. Patient suffered from recurrent...
Background Patients with inborn errors of immunity (IEI) experience recurrent infections, autoimmunity, and malignancies. Owing to repeated medical procedures, the need for constant treatment surveillance, unpredictable course disease, patients IEI are prone develop mental health disorders, including anxiety. In this study, we aimed assess prevalence level anxiety symptoms in adult Polish explore determinants group patients. Methods Data from 105 were collected via hospital depression scale...