A5041926074- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Chronic Myeloid Leukemia Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Blood disorders and treatments
- Nonmelanoma Skin Cancer Studies
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- Pancreatic and Hepatic Oncology Research
- Head and Neck Cancer Studies
- IgG4-Related and Inflammatory Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- vaccines and immunoinformatics approaches
- Adrenal and Paraganglionic Tumors
- Cutaneous lymphoproliferative disorders research
- Dupuytren's Contracture and Treatments
Pomeranian Medical University
2015-2025
University of Szczecin
2019-2021
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Liver cirrhosis, hepatitis B, C, and non-alcoholic fatty disease represent major risk factors of HCC. Multiple different treatment options are available, depending on Barcelona Clinic Cancer (BCLC) algorithm. Systemic reserved for certain patients in stages B who will not benefit from regional methods. In last fifteen years, arsenal available therapeutics has largely expanded, which improved outcomes. Nevertheless, all...
Immunotherapy is an established and efficient treatment strategy for a variety of malignancies. It aims to boost the anticancer properties one’s own immune system. Several immunotherapeutic options are available, but checkpoint blockers represent most widely known investigated. Anticancer vaccines evolving area immunotherapy that stimulate antigen-presenting cells, cytotoxic responses CD8+ T presence memory among others. Over years, different approaches have been studied, such as mRNA DNA...
Small cell cancer (SCC) is a neuroendocrine neoplasm, which most frequently found in the lungs. Extrapulmonary location of SCC rare and may involve 2.5-5% SCCs. We present case 31-year-old male patient with an extremely uncommon subglottic SCC. The was qualified for radical sequential chemoradiotherapy. After treatment, patient's condition suggested complete remission. Recurrence detected one year later, disease rapidly progressed, despite second line chemotherapy. died 29 months after...
Background: Cutaneous squamous cell carcinoma is a common malignancy, which frequently develops in the areas exposed to sun. Patients with locally advanced disease head and neck region are disqualified from surgical resection require systemic treatment. Methods: In this report, we present clinicopathological features treatment of two patients who received cemiplimab, monoclonal antibody targeting programmed death receptor 1 (PD-1). Results: An 80-year-old female 82-year-old male patient were...
At the beginning of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic, patients with inborn errors immunity (IEI) appeared to be particularly vulnerable a severe course disease. It quickly turned out that only some IEI groups are associated high risk infection. However, data on Disease 2019 (COVID-19) in still insufficient, especially children; hence, further analyses required. The retrospective study included 155 unvaccinated people IEI: 105 children and 50 adults (67.7%...
There are 7 designated conditions under the category of myeloproliferative neoplasms (MPN), including chronic myelogenous leukemia (CML) and classical MPN, that is, polycythemia vera (PV), essential thrombocythaemia (ET), primary myelofibrosis (PMF). Recently, reports about Philadelphia JAK2 V617F-positive MPN cases have been described in literature. The coexistence different molecular defects may change clinical laboratory manifestation result an inappropriate interpretation response to...
Abstract The article presents a case of 57-year-old woman with the infiltration rare small lymphocytic B cell lymphoma in thyroid gland. Initially, patient was followed-up due to chronic B-cell leukemia diagnosed on basis histopathological examination cervical lymph node. Eight months later, general symptoms occurred along lymphocytosis and exacerbation lesions nodes, therefore, chemotherapy started according COP regimen. After four cycles, further progression disease observed during...
The dynamic development of clinical immunology in Europe began mid 1980s, and was continued Poland shortly thereafter. In 1993 the first national consultant field appointed Poland. A milestone establishment Polish Working Group for Primary Immunodeficiencies (PGR PID) 2005. Since then, a network numerous paediatric internal medicine centres has been created within Group, facing resolving new challenges field. study presents organization care patients with primary secondary immunodeficiencies...
Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a rare and aggressive subtype of tumor. The disease associated with rearrangements the anaplastic lymphoma kinase (ALK). In this paper, we present clinicopathological features treatment female patient diagnosed EIMS. 2019, an 18-year-old was admitted to hospital abdominal pain. Radiological examinations confirmed large pelvic mass which subsequently resected. After re-evaluation initial histologic diagnosis, final diagnosis EIMS...
Abstract Immunotherapy is a method for the systemic treatment of malignant neoplasms. It based on abolition immunosuppressive effect cancer cells and meant to mobilize host’s immune system actively combat with disease. The group cancers which are closely connected includes: melanoma, non-small cell lung carcinoma (NSCLC), renal cancer, colon Hodgkin’s lymphoma, head neck squamous (HNSCC). Currently, immunotherapy involves checkpoint inhibitors, therapeutic vaccines, oncolytic virotherapy,...
Basal cell carcinoma (BCC) is the most frequent human skin cancer, but metastasizing BCC (MBCC) extremely rare, developing in approximately 0.0028% to 0.55% of patients. Herein, we report two cases pulmonary MBCC. The first one developed a 72-year-old male who underwent surgical resection due multiple recurrences and adjuvant radiotherapy. Immunohistochemistry showed that neoplastic cells expressed Ber-EP4, CK5/6, p63, EMA (focally), BCL-2, CD10, were negative for CK7, CK20, S100, estrogen...
ABSTRACTA case of glioblastoma multiforme in female patient suffering from common variable immune deficiency syndrome is presented. The with history previously treated due to breast carcinoma and ovarian cancer. underwent craniotomy twice followed by radiotherapy chemotherapy temozolomide finally died after 11 months.