A5029473517- Immunodeficiency and Autoimmune Disorders
- Nitric Oxide and Endothelin Effects
- Childhood Cancer Survivors' Quality of Life
- Nutrition and Health Studies
- Blood disorders and treatments
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Receptor Mechanisms and Signaling
- Respiratory viral infections research
- Hematological disorders and diagnostics
- Immune Cell Function and Interaction
- Health, Work, and Social Studies in Poland
- Chronic Lymphocytic Leukemia Research
- Renin-Angiotensin System Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer Immunotherapy and Biomarkers
- Hormonal Regulation and Hypertension
- Histiocytic Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Pharmacological Effects and Toxicity Studies
- Cardiac Ischemia and Reperfusion
- Actinomycetales infections and treatment
- Chemokine receptors and signaling
- Lymphoma Diagnosis and Treatment
- Nutrition and Health in Aging
Nicolaus Copernicus University
2015-2024
Collegium Medicum in Bydgoszcz
2015-2024
Antoni Jurasz University Hospital
2023
Creative Commons
2015
Society of Paediatric Oncology and Haematology
2014
University of Bydgoszcz
2004
Abstract Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome (WS) is a combined immunodeficiency caused by gain-of-function mutations in the C-X-C chemokine receptor type 4 ( CXCR4 ) gene. We characterize unique international cohort of 66 patients, including 57 (86%) cases previously unreported, with variable clinical phenotypes. Of 17 distinct genetic variants within our cohort, 11 were novel pathogenic affecting 15 individuals (23%). All affect same region impair...
Resveratrol is a polyphenol that presents both antineuroinflammatory properties and the ability to interact with NOS-3, what contributes vasorelaxation. Brain-derived neurotrophic factor (BNDF), molecule associated neuroprotection in many neurodegenerative disorders, considered as an important element of maintaining stable cerebral blood flow. Vascular smooth muscle cells (VSMCs) are be pathogenesis neurodegeneration potential preventative target by agents which reduce contractility vessels....
Carbamazepine (CBZ) is a first-generation anticonvulsant drug. Hence, in certain cases, therapeutic drug monitoring (TDM) supports pharmacotherapy.The presented research was based on retrospective analysis including 710 ambulatory and hospitalized patients treated with CBZ between the years 1991 2011. The method used for determination of concentration fluorescence polarization immunoassay (FPIA) performed using an Abbott GmbH TDx automatic analyzer, range carbamazepine being 4-12 µg/mL.The...
Inborn errors of immunity (IEI) refer to genetically determined disorders presenting with recurrent infections, autoimmunity, allergies, and malignancies. IEI is now commonly used, replacing the previously used term primary immunodeficiencies (PID). The 10 warning signs are widely in identification patients IEI. aim study was determine compare utility 14 diagnosing.A retrospective analysis 2851 performed (98.17% were subjects under 18 years old 1.83% adults). All questioned about four...
Objective. To compare effects of low- versus high-dose aspirin coadministered with ticagrelor on the reactivity vascular smooth muscle cells (VSMCs). Methods. Wistar rats were orally administered (10 mg/kg) and/or (2 or 10 (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>7</mml:mn></mml:math>per each 4 groups) placebo id="M2"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>9</mml:mn></mml:math>) 12 and 2 hours before experiments....
Resveratrol (3, 4', 5-trihydroxy-trans-stilbene) is a natural, non-flavonoid polyphenol that exerts protective properties against atherosclerosis-associated endothelial dysfunction and senescence. The present study aimed to assess the influence of resveratrol on vascular contractility molecular factors including sirtuin-1 (SIRT1), adiponectin calprotectin (S100A8/A9) are considered be important elements atherogenesis. A total 17 male rats were divided into control treatment group...
Abstract Background Activated PI3K delta syndrome (APDS) belongs to the heterogeneous group of primary immunodeficiency disorders (PIDs). Progress in next-generation sequencing (NGS) enabled identification gain-of-function mutations phosphoinositide 3-kinase (PI3K) genes. Depending on type causative mutation, APDS is classified into two types: 1 and 2. To date, less than 100 cases have been reported. Clinical symptoms result from impaired immune regulation are clinically manifested by...
Hydroa vacciniforme-like lymphoproliferative disorder (HV-LPD) is a cutaneous form of chronic active Epstein-Barrvirus (EBV) infection, which can develop into the extremely rare systemic lymphoma. Patients with Inborn errors immunity (IEI), such as common variable immunodeficiency (CVID), are at higher risk developing severe course infections especially viral and malignancies than general population. The aim study was to present complex diagnostic therapeutic management HV-LPD. clinical...
At the beginning of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic, patients with inborn errors immunity (IEI) appeared to be particularly vulnerable a severe course disease. It quickly turned out that only some IEI groups are associated high risk infection. However, data on Disease 2019 (COVID-19) in still insufficient, especially children; hence, further analyses required. The retrospective study included 155 unvaccinated people IEI: 105 children and 50 adults (67.7%...
Pediatric autoinflammatory diseases are rare and still poorly understood conditions resulting from defective genetic control of innate immune system, inter alia anomalies NOD2 gene. The product this gene is Nod2 protein, taking part in maintenance homeostasis. Clinical form resultant condition depends on genotype; usually patients with defects present Blau syndrome, NOD2-associated disease (NAID) or Crohn's disease. We the case a 7-year-old girl co-existing symptoms two diseases, syndrome...
The life expectancy and the risk of developing cardiovascular diseases in patients with inborn errors immunity are systematically increasing. aim study was to assess factors evaluate heart echocardiography primary antibody deficiency (PAD). Cardiac echography selected factors, including body mass index, sedentary lifestyle, nicotine, glucose, C-reactive protein, lipid profile, uric acid level, certain chronic diseases, glucocorticoid use, were analyzed 94 >18 years age PAD. Of...
Acute lymphoblastic leukemia (ALL) is the most frequent pediatric malignancy. The chemotherapy for ALL associated with a profound secondary immune deficiency.We evaluated number and phenotype of natural killer (NK) cells at diagnosis, after intensive following completion entire treatment patients ALL. fraction, absolute number, percentage NK expressing interferon-γ were determined in full blood samples. fraction CD158a, CD158b, perforin, A, B, K granzymes was examined isolated cells.We have...
Pertussis toxin (PTX) blocks G protein activation and inhibits signal transmission from the activated receptor to effectors that are specific for protein-coupled receptor. The aim of present study was evaluate effect PTX on vascular smooth muscle cells were stimulated pharmacologically with phenylephrine (α-adrenoceptor agonist), mastoparan-7 (direct G-protein activator) Bay K8644 calcium channel activator). changes in perfusion pressure proportional degree phenylephrine-induced constriction...
1. Kidwell CS, Chalela JA, Saver JL, Starkman S, Hill MD, Demchuk AM, et al. Comparison of MRI and CT for detection acute intracerebral hemorrhage. JAMA 2004; 292(15): 1823–1830. CrossRef Google Scholar
Common variable immunodeficiency (CVID) is one of the primary humoral immunodeficiencies. Despite inborn nature, first symptoms may appear in both children and adults. It characterized by hypogammaglobulinaemia, severe infections, autoimmunity, allergies, a predisposition to cancer. A delay diagnosis significant problem: time from disease implementation proper treatment usually very long. The consequence can be irreversible complications, which why it so important promote knowledge on this...
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder characterized by disruption of the lymphocyte apoptosis pathway, self-tolerance, and immune system homeostasis. Defects in genes within first signal (FAS)-mediated pathway cause an expansion autoreactive double-negative T cells leading to non-malignant lymphoproliferation, autoimmune disorders, increased risk lymphoma. The aim study was show diagnostic dilemmas difficulties process recognizing ALPS light chronic active Epstein-Barr...