A5080075894- Synthesis and biological activity
- Immune Cell Function and Interaction
- Helicobacter pylori-related gastroenterology studies
- Crystallization and Solubility Studies
- Immunotherapy and Immune Responses
- Click Chemistry and Applications
- X-ray Diffraction in Crystallography
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Immune cells in cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Tryptophan and brain disorders
- Probiotics and Fermented Foods
- Acute Lymphoblastic Leukemia research
- Immune Response and Inflammation
- Chemokine receptors and signaling
- Hemoglobin structure and function
- CAR-T cell therapy research
- Childhood Cancer Survivors' Quality of Life
- Galectins and Cancer Biology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Microfluidic and Bio-sensing Technologies
- Chemical synthesis and pharmacological studies
- Synthesis of heterocyclic compounds
- Chronic Obstructive Pulmonary Disease (COPD) Research
Nicolaus Copernicus University
2013-2025
Collegium Medicum in Bydgoszcz
2012-2025
Creative Commons
2015
Parasitic diseases, caused by intestinal helminths, remain a very serious problem in both human and veterinary medicine. While searching for new nematicides we examined series of 1,2,4-triazole derivatives 9-22, obtained during reactions N3-substituted amidrazones with itaconic anhydride. Two groups compounds, 9-16 17-22, differed the position double bond on methacrylic acid moiety. The toxicity 9-22 anti-inflammatory activity 12 19-22 were studied peripheral blood mononuclear cells (PBMC)....
The aim of the study was to find associations between levels liver injury serum markers and selected liver, peripheral leukocytes, plasma immune characteristics in biliary atresia (BA) children. Twenty‐five newly diagnosed BA children aged 4–30 weeks 12 age‐matched controls were included (for leukocytes characteristics) 19 11 studies). frequencies T helper 1 (Th1), Th2, Th17, Th17.1 cells as well numbers regulatory (Treg), B cell subsets, matrix metalloproteinase −2 −9 (MMP‐2 MMP‐9)...
Heme is a ubiquitous compound of human tissues, and it involved in cellular physiology metabolism. Once released from the cell, free heme oxidizes to ferric state (hemin). High levels hemin can cause oxidative stress inflammation if not neutralized immediately by specialized scavenger proteins. Human alpha1-antitrypsin (A1AT), an acute-phase glycoprotein important inhibitor neutrophil proteases, also hemin-binding protein. A short-term exposure freshly isolated blood neutrophils 4 µM results...
Depression is highly prevalent in COPD patients, and both diseases are believed to be associated with inflammation. The aim of this study was elucidate the role immune system alterations pathogenesis depression patients. Blood collected from patients diagnosed chronic obstructive pulmonary disease comorbid depressive symptoms [COPD + DS, (N = 13)], individuals either 16) or recurrent disorder (rDD) alone 15), healthy controls 19). Surface phenotype expression T regulatory effector cells...
1H-pyrrole-2,5-dione derivatives are known for their wide range of pharmacological properties, including anti-inflammatory and antimicrobial activities. This study aimed to synthesize new 3,4-dimethyl-1H-pyrrole-2,5-dione 2a–2f in the reaction N3-substituted amidrazones with 2,3-dimethylmaleic anhydride evaluate structural biological properties. Compounds were studied by 1H-13C NMR two-dimensional techniques (HMQC, HMBC) single-crystal X-ray diffraction (derivatives 2a 2d). The activity...
Primary hypertension is associated with still poorly known T-cell dependent immunity defects that participate in the disease development. However, relationship between peripheral subset distribution and severity humans not known. The aim of study was to find out if target organ damage adolescents primary thymus-dependent lymphocytes renewal reflected by changes phenotype characteristics.Using seven-color flow cytometry technique, we assessed CD31, CCR7 CD28 receptors expression CD45RA CD45RO...
To this day, the quest to find new drugs is still a challenge due growing demands of patients suffering from chronic inflammatory diseases and need for individualization therapy. The aim research was synthesize 1,2,4-triazole derivatives containing propanoic acid moiety investigate their anti-inflammatory, antibacterial anthelmintic activity. Compounds 3a–3g were obtained in reactions amidrazones 1a–1g with succinic anhydride. Several analyses proton carbon nuclear magnetic resonance (1H...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Eljaszewicz A, Jankowski M, Gackowska L, et al. Clinical immunologyGastric cancer increase the percentage of intermediate (CD14++CD16+) and nonclassical (CD14+CD16+) monocytes. Central European Journal Immunology. 2012;37(4):355-361. doi:10.5114/ceji.2012.32725. APA Eljaszewicz, A., Jankowski, M., Gackowska, L., Helmin-Basa, Wiese, & Kubiszewska, I. (2012). Immunology, 37(4), 355-361....
We demonstrate a novel optical method for the detection and differentiation between erythrocytes leukocytes that uses amplitude phase information provided by coherence tomography (OCT). Biological cells can introduce significant modulation with substantial scattering anisotropy dominant forward-scattered light. Such physical properties may favor use of trans-illumination imaging technique. However, an epi-illumination mode be more practical robust in many applications. This study describes...
The aim of this study was to find out if selected lactic acid bacteria (LAB) strains (antagonistic or nonantagonistic against H. pylori in vitro ) would differ their abilities modulate the DCs maturation profiles reflected by phenotype and cytokine expression patterns. Methods . Monocyte-derived elicited direct exposure LAB L. rhamnosus 900 paracasei 915 , resp.), presence absence strain cagA+ profile assessed on basis surface markers cytokines production. Results We observed that mixtures...
Acute lymphoblastic leukemia (ALL) is the most frequent pediatric malignancy. The chemotherapy for ALL associated with a profound secondary immune deficiency.We evaluated number and phenotype of natural killer (NK) cells at diagnosis, after intensive following completion entire treatment patients ALL. fraction, absolute number, percentage NK expressing interferon-γ were determined in full blood samples. fraction CD158a, CD158b, perforin, A, B, K granzymes was examined isolated cells.We have...
Abstract Background The mechanisms of downregulation protective immunity against Helicobacter pylori ( Hp ) infection strongly depend on dendritic cell (DC)‐induced T‐lymphocyte differentiation pattern. Lactic acid bacteria (LAB) strains can modulate ‐induced immunoresponse by changes in DC activation profiles. Here, we want to find out if the LAB‐pulsed DCs will change T‐cell responsiveness patterns. Materials and Methods naive peripheral CD4 + T cells were co‐cultured with CagA pulsed...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Eljaszewicz A, Gackowska L, Kubiszewska I, et al. Macrophage activity in tumour development. Contemporary Oncology/Współczesna Onkologia. 2010;14(1):1-6. doi:10.5114/wo.2010.971. APA Eljaszewicz, A., Gackowska, L., Kubiszewska, I., Jankowski, M., Urbańska, & Wiese, M. (2010). Onkologia, 14(1), 1-6. https://doi.org/10.5114/wo.2010.971 Chicago Andrzej, Lidia Izabela Michał Milena Małgorzata and Anna Helmin-Basa...
The series of new hydrazide derivatives were synthesized in reactions N3-substituted amidrazones with cyclic anhydrides as potential anti-inflammatory and antibacterial agents. compounds characterized by 1H-13C two-dimensional NMR techniques, which revealed the presence two tautomeric forms DMSO-d6 solutions, while molecular structure one species was confirmed single-crystal X-ray diffraction. effects hydrazides on peripheral blood mononuclear cells experimentally evaluated. Three showed...
Purpose . To investigate the frequency and activation status of peripheral plasmacytoid DCs (pDCs) myeloid (mDCs) as well gastric mucosa DC subset distribution in Helicobacter pylori - ( H. -) infected noninfected children. Materials Methods Thirty-six children were studied; twenty-one had The frequencies circulating pDCs (lineage HLA-DR + CD123 ) mDCs CD11c their (CD83, CD86, expression) assessed by flow cytometry. Additionally, densities , CD83 CD86 LAMP3 cells determined...
H. pylori gastritis is strongly associated with the upregulation of expression several matrix metalloproteinases (MMPs) in gastric mucosa. However, role MMP-2 and MMP-9, their inhibitors (tissue -TIMPs) produced by immune cells infected children have not been clearly defined. Moreover, effects eradication therapy on MMPs TIMPs production has evaluated. A total 84 were studied: 24-with newly diagnosed gastritis, 25-after (17 them after successful therapy), pylori-negative 11-controls. Plasma...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Eljaszewicz A, Jankowski M, Wiese-Szadkowska et al. Gastric cancer increases transmigratory potential of peripheral blood monocytes by upregulation β1- and β2-integrins. Contemporary Oncology/Współczesna Onkologia. 2018:33-37. doi:10.5114/wo.2018.73881. APA Eljaszewicz, A., Jankowski, M., Wiese-Szadkowska, Gackowska, L., Michalkiewicz, J., & Zegarski, W. (2018). Onkologia, 33-37....