A5013343748- Platelet Disorders and Treatments
- Immunodeficiency and Autoimmune Disorders
- Chemokine receptors and signaling
- Cardiovascular Syncope and Autonomic Disorders
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Drug-Induced Adverse Reactions
- Antibiotics Pharmacokinetics and Efficacy
- Heart Rate Variability and Autonomic Control
- Heart rate and cardiovascular health
- Bone fractures and treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Gastrointestinal motility and disorders
- Autoimmune Bullous Skin Diseases
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Immune Response and Inflammation
- Neonatal Respiratory Health Research
- Clostridium difficile and Clostridium perfringens research
- Genital Health and Disease
- Bacterial Identification and Susceptibility Testing
- Hip and Femur Fractures
- Congenital Ear and Nasal Anomalies
- Vascular Malformations and Hemangiomas
- Leprosy Research and Treatment
Walter Reed Army Institute of Research
2023-2024
Unifor
2014-2023
Blanchfield Army Community Hospital
2021-2022
Walter Reed National Military Medical Center
2019
Brooke Army Medical Center
2015
San Antonio Uniformed Services Health Education Consortium
2014
Abstract Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome (WS) is a combined immunodeficiency caused by gain-of-function mutations in the C-X-C chemokine receptor type 4 ( CXCR4 ) gene. We characterize unique international cohort of 66 patients, including 57 (86%) cases previously unreported, with variable clinical phenotypes. Of 17 distinct genetic variants within our cohort, 11 were novel pathogenic affecting 15 individuals (23%). All affect same region impair...
ABSTRACT Shoulder injury related to vaccine administration (SIRVA) is defined as “shoulder pain with limited range of motion within 48 hours after receipt in individuals no prior history pain, inflammation, or dysfunction the affected shoulder before administration.” Corticosteroid injections (CSIs) have been proposed a reasonable treatment modality for SIRVA, although evidence regarding efficacy scanty. In this case series, we present two patients diagnosed SIRVA who received CSI 5 days...
A case report of recalcitrant allergic fungal sinusitis (AFS) refractory to systemic corticosteroids and multiple functional endoscopic sinus surgeries (FESSs) treated with anti-IgE antibody omalizumab is reported. AFS often classified chronic rhinosinusitis (CRS). Although similar symptoms are among the two diseases, has a unique pathophysiology. Patients demonstrate type 1 hypersensitivity allergens, increased total serum IgE, CD8 + T-cell prevalence, IL-4 IL-5 response. Omalizumab should...
Background and Aims . Studies have shown effects of diet on gut microbiota. We aimed to identify foods associated with recurrent Clostridium difficile infection (CDI). Methods In this cross-sectional survey, consecutive patients diagnosed CDI were identified by electronic medical records. Colitis symptoms positive assay confirmed. Health-care onset-health-care facility was excluded. Food surveys mailed 411 patients. Survey responses served as the primary outcome measure. Spearman’s rank...
s Presented at the Sixth Annual Meeting of Orthopaedic Trauma Association: Toronto, Canada, November 7–10, 1990: PDF Only
We sought to better understand the utility and role of animal models infection for Food Drug Administration (FDA)-approved antibiotics indications community-, hospital-acquired-, ventilator-associated bacterial pneumonia (CABP, HABP, VABP), complicated urinary tract (cUTI), intra-abdominal (cIAI), acute skin structural infections (ABSSSIs). reviewed relevant documents from new drug applications (NDA) FDA-approved 2014–2019 above indications. Murine neutropenic thigh supported choice a...
Abstract Plerixafor is a CXCR4 antagonist approved in 2008 by the FDA for hematopoietic stem cell collection. Subsequently, plerixafor has shown promise as potential pathogen‐agnostic immunomodulator variety of preclinical animal models. Additionally, investigator‐led studies demonstrated prevents viral and bacterial infections patients with WHIM syndrome, rare immunodeficiency aberrant signaling. Here, we investigated whether could be repurposed to treat sepsis or severe wound infections,...
Abstract Background: Significant clinical similarities have been observed between the recently described ‘Long-Haul’ COVID-19 (LHC) syndrome, Postural Orthostatic Tachycardia Syndrome (POTS) and Inappropriate Sinus (IST). Shared symptoms include light-headedness, palpitations, tremulousness, generalized weakness, blurred vision, chest pain, dyspnea, “brain-fog”, fatigue. Ivabradine is a selective sinoatrial node blocker FDA-approved for management of tachycardia associated with stable angina...
Abstract Background: Significant clinical similarities have been observed between the recently Described ‘Long-Haul’ COVID-19 (LHC) syndrome, Postural Orthostatic Tachycardia Syndrome (POTS) and Inappropriate Sinus (IST). Shared symptoms include light-headedness, palpitations, tremulousness, generalized weakness, blurred vision, chest pain, dyspnea, “brain-fog”, fatigue. Ivabradine is a selective sinoatrial node blocker FDA-approved for management of tachycardia associated with stable angina...
The diversity of the cutaneous manifestations syphilis and ability spirochete to evade diagnosis have been well documented by medical literature. However, what triggers onset secondary is not yet clear because difficulties studying bacterium. Our case describes a heterogeneous rash (or coexisting rashes) that presented day after vaccination with Moderna mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. potential etiologies patient's rash: A vaccine reaction,...