A5003246704- Neurofibromatosis and Schwannoma Cases
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Neutropenia and Cancer Infections
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Soft tissue tumor case studies
- Meningioma and schwannoma management
- Sarcoma Diagnosis and Treatment
- Pharmaceutical studies and practices
- Inflammasome and immune disorders
- Antifungal resistance and susceptibility
- Acute Myeloid Leukemia Research
- Blood disorders and treatments
- Lymphoma Diagnosis and Treatment
- Tuberous Sclerosis Complex Research
- Chronic Myeloid Leukemia Treatments
- Blood groups and transfusion
- Bone Tumor Diagnosis and Treatments
- Health, Work, and Social Studies in Poland
- Fungal Infections and Studies
- Hematological disorders and diagnostics
- Protein Tyrosine Phosphatases
- Platelet Disorders and Treatments
Nicolaus Copernicus University
2008-2023
Antoni Jurasz University Hospital
2017-2023
Collegium Medicum in Bydgoszcz
2016-2020
Background/Aim: Neurocutaneous disorders, also referred as phacomatoses, are congenital disorders manifesting at different ages with central nervous system and cutaneous abnormalities. Analysis of the demographic clinical profile patients phacomatoses in context incidence spectrum malignancy. Materials Methods: This is a retrospective analysis 20 years data single-center study Poland. Results: Phacomatoses were diagnosed 45.6% (913/2,003) patients, including 61.4% children. The distribution...
Introduction: We analyzed the epidemiology and outcomes of treatment invasive fungal disease (IFD) in children during anticancer therapy (PHO, pediatric hematology oncology) or after hematopoietic cell transplantation (HCT) over a period eight consecutive years single-center study. Material methods: Overall, total 254 HCTs were performed, 415 newly diagnosed for malignancy. Incidence, outcome IFD analyzed. Results: The cumulative incidence any was 32.6% allo-HCT, 22.2% PHO, 6.0% auto-HCT...
Coordinated medical care offered in Poland for patients suffering from neurofibromatosis type 1 and related RASopathies combines complex multispecialty consultation with permanent supervision the patient’s oriented longitudinal care. Neurofibromatosis is one of most common single gene disorders global population, observed out 2500–3000 live births. It a primary neoplasia disease 100% penetration mutation but remarkable age-dependent onset different signs symptoms, outstanding clinical...
Abstract Introduction Leukemia belong to 31% of all childhood malignancies. Acute lymphoblastic leukemia (ALL) is the most frequent type pediatric accounting for 80–85% cases. Progress in diagnostics and therapy dependent on international cooperation. The objective study was analysis non-hematological toxicity during intensive chemotherapy according two consecutive intercontinental protocols. Patients methods A total number 210 children diagnosed ALL who were treated single center between...
Introduction: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Risk factors childhood ALL have changed during recent decades, mostly due to treatment personalization. The aim of this study was analyze therapy results and prognostic Kujawsko-Pomorski region Poland between 1976 2018. Material methods: Data from 495 patients (0–18 years old) diagnosed with 2018 analyzed. Prognostic were analyzed separately specific therapeutic groups, which defined by several...
Therapy results in pediatric Hodgkin lymphoma reflect remarkable progress oncology. In the last decade, relevant development of new therapeutic options for children with refractory or relapsed disease has been made. this study, we retrospectively analyzed therapy and risk factors treated a single oncology center according to five protocols. Data from 114 by institution between 1997 2022 were analyzed. Classic divided into four periods: 1997-2009, 2009-2014, 2014-2019, 2019-2022. For nodular...
Bone abnormalities occur often in patients with neurofibromatosis type 1 (NF1). This suggests that the metabolism of bone tissue may be affected these patients. Evaluation markers mineral density and respect to NF1. A total number 57 NF1 145 controls were studied. Activity or concentrations following mineralization performed on all patients: bone-specific alkaline phosphatase (BAP), osteoprotegerin (OPG) collagen I crosslinked C-telopeptide (CTX). observed 75.44% had a significant decrease...
Introduction. Controversial data on disturbances in mineral homeostasis and bone mass were reported children with diagnosed untreated acute lymphoblastic leukemia (ALL). Early detection of metabolism abnormalities is important for monitoring the effect therapy skeleton. The purpose this study was to evaluate adolescents newly by assessing biomarkers cell activity. Materials methods. Propeptide type 1 procollagen (P1NP) osteocalcin (OC) as formation markers C-terminal telopeptide collagen...
Neurofibromatosis type 1 (NF1) is characterized by the occurrence of multisystem tumors, among which most characteristic are optic pathway gliomas (OPGs) and plexiform neurofibromas (PNFs). With development new anticancer drugs targeting immune system, it important to examine immunological status patients with NF1. Furthermore, system has been suggested as a probable modulator NF1-associated phenotypes. The objective this study was analysis lymphocyte subset populations respect presence PNFs...
Abstract Background/Aim Neurofibromatosis type 1 (NF1) is characterized by the occurrence of multisystem tumors. The objective this study was to analyze demographic and oncological profile 830 NF1-individuals regarding prevalence, type, spectrum malignancy. Patients methods medical records patients diagnosed with NF1 a median age 22.1 years (range: 0.8–81.6 years) who were followed up for malignancies from 1999 2018 retrospectively reviewed. Results prevalence malignancy occurring in 34.8%...
B a c k g r o u n d . Acute lymphoblastic leukemia (ALL) is the most frequent pediatric malignancy. Presence of adverse risk factors determines group stratification in this disease.O b j e t i v The aim study was analysis results therapy and role prognostic treatment childhood ALL kujawsko-pomorskie region 1995-2010.P s m h During period, diagnosed 223 patients. With respect to time period protocol, patients were divided into two groups: 1 A/B (1995-2002) 2 (2002- 2010). Probability overall...
Introduction: Over recent decades, significant progress in the treatment of childhood acute myeloid leukemia (AML) has been made. However, relapsed disease remains a challenge. The aim this study was to analyze therapy results pediatric patients treated for AML single oncology center, with particular focus on prognostic factors. Materials and methods: Data from younger than 19 years diagnosed between January 1994 December 2020 Department Pediatric Hematology Oncology Bydgoszcz, Poland...
Jacobsen syndrome is a rare genetic disorder associated with deletion of the long arm chromosome 11, which includes band 11q23.1 or 11q24.1.Genetic changes occur de novo in 85%