A5018461734- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Renal and related cancers
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Parvovirus B19 Infection Studies
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Protein Degradation and Inhibitors
- Cardiac tumors and thrombi
- Quinazolinone synthesis and applications
- Childhood Cancer Survivors' Quality of Life
- PI3K/AKT/mTOR signaling in cancer
- Agriculture, Plant Science, Crop Management
- Synthesis and Characterization of Heterocyclic Compounds
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Cytokine Signaling Pathways and Interactions
Nicolaus Copernicus University
2012-2022
Collegium Medicum in Bydgoszcz
2012-2021
Szpital Kliniczny Nr 1 we Wrocławiu
2014
Abstract Mutations in isocitrate dehydrogenase 1 and 2 ( IDH1/2 ) genes occur about 20% patients with acute myeloid leukemia (AML), leading to DNA hypermethylation epigenetic deregulation. We assessed the prognostic significance of mutations + 398 AML normal karyotype (NK-AML), treated daunorubicine cytarabine (DA), DA cladribine (DAC), or fludarabine. IDH2 mutation was an independent favorable factor for 4-year overall survival (OS) total NK-AML population (p = 0.03, censoring at...
The aim of the study was to evaluate selected angiogenic factors in patients with essential thrombocythemia (ET) depending on JAK2V617F, calreticulin gene (CALR) and myeloproliferative leukemia virus oncogene (MPL) mutations. Sixty ET 20 healthy volunteers were enrolled study. following tests performed: vascular endothelial growth factor- A (VEGF-A), soluble factor receptor-1 (sVEGFR-1),soluble receptor-2 (sVEGFR-2), platelet-derived factor( PDGF-BB), stromal-derived factor-1α (SDF-1α). We...
External quality assurance (EQA) programs are vital to ensure high and standardized results in molecular diagnostics. It is important that EQA for quantitative analysis takes into account the variation methodology. Results cannot be expected more accurate than limits of technology used, it essential recognize factors causing substantial outlier results. The present study aimed identify parameters specific importance JAK2 V617F quantification by PCR, using different starting materials,...
An emerging problem in patients with chronic myeloid leukemia (CML) is increasing resistance to tyrosine kinase inhibitors (TKIs). To determine genetic and cellular mechanisms involved the development of TKIs, nine imatinib-resistant cell lines were derived from K- 562 line followed by testing drug sensitivity, multidrug proteins cytogenetic studies. In cross-resistance daunorubicin, etoposide cytarabine observed whereas sensitivity dasatinib, nilotinib, cyclophpsphamide, bortezomib busulfan...
Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children. The factors predisposing to ALL remain mostly unknown. Natural killer (NK) cells are a component of innate immunity. Their role eliminate that were infected with viruses or underwent neoplastic transformation. activity NK regulated by their activating and inhibitory receptors, inter alia killer-cell immunoglobulin-like receptors (KIRs). available data about link between incidence KIR genotype highly...
B a c k g r o u n d . Acute lymphoblastic leukemia (ALL) is the most frequent pediatric malignancy. Presence of adverse risk factors determines group stratification in this disease.O b j e t i v The aim study was analysis results therapy and role prognostic treatment childhood ALL kujawsko-pomorskie region 1995-2010.P s m h During period, diagnosed 223 patients. With respect to time period protocol, patients were divided into two groups: 1 A/B (1995-2002) 2 (2002- 2010). Probability overall...
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Abstract Acute myeloid leukemia (AML) is a clonal disorder that results from errors in proliferation and differentiation of bone marrow stem cells lineage. According to the Gilliland “two-hit” model, genes both groups related (e.g., FLT3 ) CEBPA must be mutated for full development AML. The genetic background AML very complicated varied, single nucleotide mutations or changes gene expression cytogenetic aberrations. DNA sequencing enable identification important alterations occur first may...