A5058872525- Angiogenesis and VEGF in Cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Kruppel-like factors research
- Lymphatic System and Diseases
- Cancer Risks and Factors
- Birth, Development, and Health
- Blood Coagulation and Thrombosis Mechanisms
- Vascular Tumors and Angiosarcomas
- Diabetes Management and Research
- Cytomegalovirus and herpesvirus research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Systemic Sclerosis and Related Diseases
- Chronic Myeloid Leukemia Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Herpesvirus Infections and Treatments
- Obesity, Physical Activity, Diet
- Cerebrovascular and Carotid Artery Diseases
- Acute Myocardial Infarction Research
- Diabetes and associated disorders
- Platelet Disorders and Treatments
- Acute Ischemic Stroke Management
- Gestational Diabetes Research and Management
- Parvovirus B19 Infection Studies
- Cancer, Hypoxia, and Metabolism
- Prenatal Screening and Diagnostics
Poznan University of Medical Sciences
2019-2022
Nicolaus Copernicus University
2018-2021
Collegium Medicum in Bydgoszcz
2018-2021
Medical University of Lodz
2015
Expression Génétique Microbienne
2006
Centre National de la Recherche Scientifique
2006
Université Paris Cité
2006
Institute of Human Genetics
2006
Polish Academy of Sciences
2006
The aim of the study was to evaluate influence age and gender on prevalence overweight obesity, body composition fatty tissue distribution in young adults with type 1 diabetes.197 patients diabetes aged 20-40 years participated study. control group consisted 138 healthy adults. Body weight, height, waist hip circumferences were measured. Analysis mass performed using bioimpedance. Study groups stratified into cohorts <30 30+ years.Overweight obesity diagnosed 35.5% 13.2% diabetic 26.1% 7.3%...
Abstract Determination of antibodies against ToRCH antigens at the beginning pregnancy allows assessment both maternal immune status and risks to an adverse outcome. Age-standardised seroprevalences were determined in sera from 1009 women childbearing age residing Mexico, Brazil, Germany, Poland, Turkey or China using a multiparametric immunoblot containing antigen substrates for Toxoplasma gondii , rubella virus, cytomegalovirus (CMV), herpes simplex viruses (HSV-1, HSV-2), Bordetella...
Gestational diabetes mellitus (GDM) is described as a glucose intolerance of variable severity which begun or was firstly recognized during gravidity. Two major metabolic disorders, insulin resistance and β-cell dysfunction, currently play role in pathogenesis GDM. Our intention to investigate total serum homocysteine vitamin B12 levels pregnant women with GDM non-diabetic gravid women.Serum were prospectively measured 79 women, 60 whom diagnosed GDM, 19 healthy controls. Serum analyzed by...
The interaction between Hfq and RNA is central to multiple regulatory processes. Using site-directed mutagenesis, we have found a missense mutation in (V43R) which strongly affects2 the binding capacity of protein its ability stimulate poly(A) tail elongation by poly(A)-polymerase vitro . In vivo , overexpression this variant fails rpoS–lacZ expression does not restore normal growth rate hfq null mutant. Cells wild-type gene has been replaced V43R allele exhibit phenotype intermediate those...
Recently, there is great interest in vasculogenesis, a process of the formation new blood vessels from progenitor cells or angioblasts, pathogenesis cancer. To best our knowledge, evaluation endothelial (EPCs) Hodgkin's lymphoma has not yet been reported. The aim present study was to assess number EPCs and selected cytokines, such as vascular growth factor (VEGF-A) stromal cell-derived (SDF-1α) involved vasculogenesis patients. conducted group 42 patients with (eight relapsed 34 before first...
Abstract The highly conserved Pumilio protein plays crucial roles in fertility of many organisms acting as a repressor translation, and causing infertility when mutated. Although one two human homologs, PUMILIO2 is expressed mainly the germ line, its role mammalian cell development has not been reported yet. To shed light on male we screened this gene for mutations 137 patients presenting variety phenotypes with spermatogenic failure. first variant, identified was single base substitution...
Background and objectives: Recent studies suggest that a vascular endothelial growth factor (VEGF-A) may be involved in the thrombotic process by stimulating expression of tissue cells. Tissue (TF) can also stimulate transcription gene encoding VEGF-A. The relationship between coagulation angiogenesis myeloproliferative neoplasms is not fully understood. aim this study was to evaluate concentration TF relation VEGF-A blood patients with essential thrombocythemia (ET). Patients methods: group...
The aim of the study was to evaluate selected angiogenic factors in patients with essential thrombocythemia (ET) depending on JAK2V617F, calreticulin gene (CALR) and myeloproliferative leukemia virus oncogene (MPL) mutations. Sixty ET 20 healthy volunteers were enrolled study. following tests performed: vascular endothelial growth factor- A (VEGF-A), soluble factor receptor-1 (sVEGFR-1),soluble receptor-2 (sVEGFR-2), platelet-derived factor( PDGF-BB), stromal-derived factor-1α (SDF-1α). We...
Neoangiogenesis is mediated by circulating bone marrow-derived endothelial progenitors (circulating EPCs). The aim of the study was quantification EPCs from peripheral blood mononuclear cells invasive breast cancer (IBrC) patients flow cytometry, before and after adjuvant treatment. A total 88 stage IA-IIB primary IBrC were enrolled prospectively. Circulating with immune-phenotype CD45-CD34+CD133+CD31+ assessed. Treatment significantly reduced number EPCs/µL in general cohort. However, there...
The aim of the study was to evaluate diurnal changes tissue factor (TF) and pathway inhibitor (TFPI) concentrations in relation on-treatment platelet reactivity. group included 51 patients with acute myocardial infarction (AMI) treated primary percutaneous coronary intervention dual antiplatelet therapy. TF TFPI were assessed using enzyme-linked immunosorbent assay kits. We found a significant increase concentration clopidogrel-resistant, but not clopidogrel-sensitive, at 10.00 a.m. (410.66...
Background: The aim of the study was to assess number endothelial progenitor cells (EPCs) in patients with acute stroke due cerebral microangiopathy and evaluate whether there is a relationship between their clinical status, radiological findings, risk factors, selected biochemical parameters, prognosis, both ischemic hemorrhagic stroke. Methods: In total, 66 lacunar stroke, 38 typical location 22 subjects from control group without cerebrovascular incidents were included prospective...
Psoriasis vulgaris (PsV) is a common dermatosis characterized by excessive activation of neovascularization. Latest research has shown that endothelial progenitor cells (EPCs) are crucial factor involved in the repair injury and formation new blood vessels, process termed postnatal vasculogenesis. However, exact mechanism creating psoriatic skin patches involvement EPCs this remains unknown.To evaluate number patients with PsV, expression specific cell surface markers, including CD45-,...
Aim: The assessment of angiogenic parameters in so-called “liquid tumors”, such as myeloproliferative neoplasms, remains an open clinical issue. aim the study is to evaluate concentration vascular endothelial growth factor (VEGF-A) and soluble receptors sVEGFR-1 sVEGFR-2 relations risk factors thrombosis patients with polycythemia vera (PV). Material/Methods: A total 45 suffering from newly diagnosed PV 30 healthy volunteers were enrolled into study. Polycythemia was according WHO (2008)...
Objectives: Based on the current state of knowledge, elevated levels oxidative stress markers may be considered as risk factors for pregnancy complications. The aim research was to assess correlation between selected biomarkers with occurrence foetal chromosomal aberration and congenital malformations. Material methods : This retrospective lasted two years. purpose determine serum markers, including total protein (TP), glutathione (GSH), S-nitrosothiols (RSNO), nitric oxide (NO), trolox...
The aim of the study was to assess activity protein C, S and tissue factor pathway inhibitor in relation risk factors for thrombotic complications patients with essential thrombocythemia. group consisted 45 newly diagnosed Protein determined by chromogenic method. Activities C (TFPI) were using ELISAs. Significantly lower but higher TFPI found ET comparison control group. women as compared men, over 60 years age below age. leukocytes count at least 11 g/l than difference almost reached...