A5006380317- Celiac Disease Research and Management
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Infant Health and Development
- Digestive system and related health
- Inflammatory Bowel Disease
- Food Allergy and Anaphylaxis Research
- Trace Elements in Health
- Cardiac electrophysiology and arrhythmias
- Probiotics and Fermented Foods
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Liver Diseases and Immunity
- Eosinophilic Esophagitis
- Ion channel regulation and function
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Autophagy in Disease and Therapy
- Cardiac pacing and defibrillation studies
- Ecology and biodiversity studies
- Cancer Cells and Metastasis
- Sperm and Testicular Function
- Congenital Anomalies and Fetal Surgery
- Pediatric Hepatobiliary Diseases and Treatments
- Mesenchymal stem cell research
Children's Memorial Health Institute
2015-2024
Instytut Matki i Dziecka
2024
Medical University of Lodz
2022
Memorial
2022
Medical University of Silesia
2017
Great Ormond Street Hospital
2017
University College London
2017
Pediatrics and Genetics
2017
Medical University of Warsaw
2012-2015
Warsaw University of Life Sciences
2008-2011
The purpose of the randomized double-blind placebo-controlled trial was to assess effectiveness synbiotic preparation containing probiotic Lactobacillus rhamnosus FloraActive™ 19070-2, acidophilus DSMZ 32418, Bifidobacterium lactis 32269, longum 32946, bifidum 32403 and fructooligosaccharides in adult patients with diarrhea-dominant IBS (IBS-D). study included eighty moderate severe IBS-D who were receive synbiotics or placebo for eight weeks. Finally, a total sixty-eight finished study....
Probiotics seem to have promising effects in the prevention and treatment of allergic conditions including atopic dermatitis (AD) food allergy. The purpose this multicenter randomized placebo-controlled trial was evaluate effectiveness a probiotic preparation comprising Lactobacillus rhamnosus ŁOCK 0900, 0908, casei 0918 children under 2 years age with AD cow’s milk protein (CMP) study enrolled 151 children, who—apart from being treated CMP elimination diet—were receive at daily dose 109...
The aim of this randomized double-blind placebo-controlled study was to evaluate the effectiveness and safety multi-strain probiotic in adults with diarrhea-predominant irritable bowel syndrome (IBS-D). patients were receive a mixture Lactobacillus, Bifidobacterium, Streptococcus thermophilus strains or placebo for eight weeks. Primary endpoints included changes symptom severity improvement assessed IBS Severity Scoring System (IBS-SSS) Global Improvement Scale (IBS-GIS). comparison...
Increased intestinal permeability is considered to play a crucial role in the pathogenesis of inflammatory bowel diseases (IBD). Therefore, recently, use non-invasive biomarkers both diagnosis and monitoring IBD emphasized. The aim this study was investigate fecal serum zonulin I-FABP pediatric patients their correlation with calprotectin (FCP).
HO1 (haem oxygenase 1) and Fpn (ferroportin) are key proteins for iron recycling from senescent red blood cells therefore play a major role in controlling the bioavailability of erythropoiesis. Although important aspects metabolism HO1-deficient (Hmox1-/-) mice have already been revealed, little is known about regulation expression its deficiency. In present study, we characterize cellular systemic factors influencing Hmox1-/- bone marrow-derived macrophages liver kidney mice. macrophages,...
Individual populations show a variety of sensitization patterns, which may be associated with the geographic region, climate, dietary habits, or ways preparing food. The purpose this study was to comprehensively assess food allergy profile in Polish children, particularly eight allergens (so-called “the Big 8”): cow milk, eggs, wheat, soybeans, fish, crustacean shellfish, tree nuts, and peanuts. To prevalence serum levels specific immunoglobulins E (sIgE), we analyzed results obtained from...
Celiac disease (CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically predisposed individuals, affecting about 1% general population developed world. In 2012, European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) recommendations CD diagnoses children adolescents were introduced, allowing "no-biopsy" approach if certain criteria met. This was also confirmed revised guidelines published 2020. Thus, aim this study to...
There is evidence that children with autism spectrum disorders (ASDs) display an increased immune reactivity against gluten, which supposed to be the effect of intestinal barrier abnormalities. The aim study was evaluate relation antibody induced by gluten zonulin and fatty acid binding proteins (I-FABP), is, serological markers impaired gut barrier. included 77 patients ASDs. Zonulin, I-FABP, celiac-specific antibodies, anti-gliadin antibodies (AGA), neural transglutaminase 6 (TG6)...
Autoantibodies occur in healthy subjects as well children with Wilson's disease (WD), but their prevalence and significance are unknown. Thus, we aimed to assess the of autoantibodies autoimmune markers, relationship liver injury WD children. The study included 74 75 a control group. Patients underwent transient elastography (TE) examinations, determination function tests, copper metabolism serum immunoglobulins (Ig). In sera patients controls, anti-nuclear (ANA), anti-smooth muscle,...
In Wilson disease (WD), liver copper (Cu) excess, caused by mutations in the ATPase Cu transporting beta (ATP7B), has been extensively studied. contrast, gastrointestinal tract, responsible for dietary uptake, ATP7B malfunction is poorly explored. We therefore investigated gut biopsies from WD patients and compared intestines two rodent models human knock-out intestinal cells to their respective wild-type controls. observed (GI) inflammation patients, rats mice lacking ATP7B. Mitochondrial...
modulation of gut microbiota by probiotics has been proposed as a target for intervention to reduce bone mineral density (BMD) loss in the postmenopausal period. This study aims evaluate effect
Equine herpesvirus-1 (EHV-1) infections cause significant economic losses for equine industries worldwide as a result of abortion, respiratory illness, and neurologic disease in all breeds horses.The occurrence abortions caused by EHV-1 has repeatedly been confirmed Poland, but neurological manifestations the infection have not described yet.Also it is unknown how neurons with non-neuropathogenic strains regulated.To further understand virus-neuron interaction we studied two murine primary...
The aim of the present study was to evaluate effects three formulated diets: wheat-gluten-protein-based diets supplemented with Lys-Gly dipeptide (LG) or free lysine and glycine (FL), a control diet without supplementation (C) commercial starter Bio Oregon (BO) for on growth digestive system morphology yellow perch. After 48 days experimental feeding, fish fed LG showed highest body mass. Fish number gastrin/cholecystokinin positive cells lowest CD3-positive cells. brush border anterior...
Probiotics offer a potential new therapeutic approach for irritable bowel syndrome (IBS), but current results are still controversial. The aim of this study was to assess the efficacy and safety single-strain probiotic formulations in adult IBS patients compare effects Bifidobacterium lactis NORDBIOTIC™ BI040 (DSM 33812/34614) Bacillus coagulans BC300 33836) prospective three-arm interventional randomized double-blind placebo-controlled clinical trial. included 123 subjects diagnosed...
Abstract The structural organization of the spermatozoon from Eurasian beaver, Castor fiber (Family: Castoridae), was determined and compared to that other sciuromorph rodents. beaver has a head, which is variable in form but usually paddle‐shaped, with small nucleus very large acrosome, tail relatively short most Transmission electron microscopy indicates testicular spermatozoa acrosome projects apically, although few it becomes partly flexed. During final stages maturation, however, highly...