A5065270429- Iron Metabolism and Disorders
- Trace Elements in Health
- Hemoglobinopathies and Related Disorders
- Heavy Metal Exposure and Toxicity
- Heme Oxygenase-1 and Carbon Monoxide
- Plant Micronutrient Interactions and Effects
- Folate and B Vitamins Research
- Thermodynamic properties of mixtures
- Ionic liquids properties and applications
- Infant Nutrition and Health
- Erythropoietin and Anemia Treatment
- Liver Disease Diagnosis and Treatment
- Neurological diseases and metabolism
- Phase Equilibria and Thermodynamics
- Clinical Nutrition and Gastroenterology
- RNA regulation and disease
- Magnesium in Health and Disease
- Chemical and Physical Properties in Aqueous Solutions
- Amyotrophic Lateral Sclerosis Research
- Lipid metabolism and disorders
- Monoclonal and Polyclonal Antibodies Research
- Neonatal Health and Biochemistry
- Pregnancy and preeclampsia studies
- T-cell and B-cell Immunology
- Multiple Sclerosis Research Studies
Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences
2020-2025
Polish Academy of Sciences
2015-2024
Institute of Plant Genetics, Polish Academy of Sciences
2004-2024
University of Life Sciences in Poznań
2018-2019
Warsaw University of Technology
2014-2016
Centre National de la Recherche Scientifique
2000
Institut de Chimie des Substances Naturelles
2000
Instytut Chemii i Techniki Jądrowej
2000
Inserm
1998
Institut Curie
1998
The aim of the study was to establish an optimized protocol iron dextran administration pig neonates, which better meets demand for erythropoiesis. Here, we monitored development red blood cell indices, plasma parameters during a 28-day period after birth (till weaning), following intramuscular different concentrations suckling piglets. To assess status developed novel mass spectrometry assay quantify levels iron-regulatory peptide hormone hepcidin-25. This is predominantly secreted by liver...
Heme is an efficient source of iron in the diet, and heme preparations are used to prevent cure deficiency anemia humans animals. However, molecular mechanisms responsible for absorption remain only partially characterized. Here, we employed young iron-deficient piglets as a convenient animal model determine efficacy oral supplementation investigate pathways absorption. The use bovine hemoglobin dietary was found efficiently counteract development piglets, although it did not fully rebalance...
HO1 (haem oxygenase 1) and Fpn (ferroportin) are key proteins for iron recycling from senescent red blood cells therefore play a major role in controlling the bioavailability of erythropoiesis. Although important aspects metabolism HO1-deficient (Hmox1-/-) mice have already been revealed, little is known about regulation expression its deficiency. In present study, we characterize cellular systemic factors influencing Hmox1-/- bone marrow-derived macrophages liver kidney mice. macrophages,...
Abstract Background The critically low hepatic iron stores of newborn piglets are considered to be a major cause neonatal deficiency in modern breeds domestic pig ( Sus domestica ). main factor believed contribute this phenomenon is large litter size, which has been an objective selective breeding pigs for decades. As consequence, transferred from the pregnant sow distributed among greater number fetuses. Results Here, we investigated whether size influences red blood cell (RBC) indices and...
The demand for iron is high in pregnancy to meet the increased requirements erythropoiesis. Even pregnant females with initially iron-replete stores develop iron-deficiency anemia, due inadequate absorption. In anemic females, maternal supply dedicated maintaining metabolism fetus and placenta. Here, using a mouse model of deficiency pregnancy, we show that recycled from senescent erythrocytes becomes predominant source this microelement can be transferred placenta depleted stores....
This work reports the measurements of vapor pressure, excess enthalpy mixing, and molar heat capacity for selected {ionic liquid + water} binary systems. The studied ionic liquids are 1-ethyl-1-methylpiperidinium ethylsulfate, 1-ethyl-1-methylpyrrolidinium 1-ethyl-1-methylmorpholinium ethylsulfate. isothermal vapor–liquid phase equilibria have been measured by an ebulliometric method within temperature range from 338.15 to 368.15 K pressure up pure water. Excess was with titration...
In pigs, iron deficiency anemia (IDA) is a common disorder that occurs during the early postnatal period, leading to stunted growth and increased mortality of piglets. The main cause IDA low stores in liver newborn piglets; these constitute source needed satisfy erythropoietic requirements piglets their first weeks life. Insufficient are usually due inadequate placental transfer from sow fetuses. Therefore, supplementation pregnant sows has been implemented enhance increase accumulation Over...
Iron and oxygen (O2) are intimately associated in many well characterized patho-physiological processes. These include oxidation of the [4Fe-4S] cluster mitochondrial aconitase inactivation this Krebs cycle enzyme by superoxide anion (O2*-), a product one-electron reduction O2. In contrast to apparent toxicity reaction, biological consequences O2*- -mediated cytosolic counterpart aconitase, commonly known as iron regulatory protein 1 (IRP1), not clear. Apart from its ability convert citrate...
Iron deficiency is the most common mammalian nutritional disorder. However, among species iron anemia (IDA), occurs regularly only in pigs. To cure IDA, piglets are routinely injected with high amounts of dextran (FeDex), which can lead to perturbations homeostasis. Here, we evaluate therapeutic efficacy non-invasive supplementation Sucrosomial (SI), a highly bioavailable supplement preventing IDA humans and mice various oxide nanoparticles (IONPs). Analysis red blood cell indices plasma...
The continuous recycling of haem iron following phagocytosis and catabolism senescent damaged red blood cells by macrophages is a crucial process in the maintenance systemic homoeostasis. However, little known about macrophage handling haemolytic states resulting from deficiency antioxidant defences. Our observations indicate that recently described chronic, but moderate regenerative, anaemia aged SOD1 (superoxide dismutase 1)-knockout mice associated with cell modifications sensitivity to...