A5071768793- Inflammatory Bowel Disease
- Digestive system and related health
- Microscopic Colitis
- Child Nutrition and Feeding Issues
- Cystic Fibrosis Research Advances
- Celiac Disease Research and Management
- Viral gastroenteritis research and epidemiology
- Infant Nutrition and Health
- Eosinophilic Esophagitis
- Immunodeficiency and Autoimmune Disorders
- Clinical Nutrition and Gastroenterology
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Nutrition and Health Studies
- Liver Diseases and Immunity
- Food Allergy and Anaphylaxis Research
- Congenital Anomalies and Fetal Surgery
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Helicobacter pylori-related gastroenterology studies
- Hepatitis Viruses Studies and Epidemiology
- Metabolism and Genetic Disorders
- Asthma and respiratory diseases
- Gastroesophageal reflux and treatments
- Infant Health and Development
Medical University of Silesia
2015-2024
Górnośląskie Centrum Zdrowia Dziecka w Katowicach
2020-2022
Katowice School of Economics
2013-2022
Pediatrics and Genetics
2017
Children's Memorial Health Institute
2017
Great Ormond Street Hospital
2017
University College London
2017
University of Liverpool
2014
Liverpool Heart and Chest Hospital
2014
Amsterdam UMC Location University of Amsterdam
2013
The aim of the present study was to compare efficacy and safety 2 protocols maintenance therapy with infliximab (IFX) an immunomodulatory agent in pediatric patients Crohn disease (CD): withdrawal immunomodulators versus continuation immunosuppressants.The multicenter randomized open-label trial included 99 CD (ages 14.5 ± 2.6 years) who were administered IFX (5 mg/kg body weight) along (azathioprine 1.5-3 weight per day, methotrexate 10-25 mg/week). After 10 weeks induction therapy, 84...
Recently, an increase in the incidence of inflammatory bowel disease (IBD) has been observed, especially among children and adolescents. Currently, few studies focus on differentiation inflammation IBD subunits, i.e., Crohn’s Disease (CD) Ulcerative Colitis (UC). The aim this study was to compare concentrations proinflammatory mediators arachidonic acid (ARA) linoleic (LA) patients with CD (n = 34) UC 30), order identify differences both diseases within same entity, according activity....
Although vitamin K deficiency has been implicated in adult inflammatory bowel disease (IBD), its prevalence pediatric IBD remains unknown. We carried out a cross-sectional study 63 children with Crohn's (CD) and 48 ulcerative colitis (UC) to assess the of search for potential correlation between status activity. Vitamin was assessed using protein induced by absence-II (PIVKA-II; ELISA). Prevalence 54.0% CD 43.7% UC. more common patients higher activity, mass Z-scores less among treated...
Background: Turner Syndrome is associated with an increased risk of autoimmune diseases, such as thyroiditis, coeliac disease, type 1 diabetes mellitus, inflammatory bowel alopecia areata, or vitiligo. The presence isochromosome iXq and exposure to estradiol may contribute the development process. aim this study was determine prevalence diseases in a group TS patients assess impact karyotype puberty on diseases. Patients & Methods: analysis encompassed clinical biochemical data 134 treated...
There are only a few studies on immune response to routine vaccinations in children with inflammatory bowel disease (IBD), despite strong need for this kind of study. The aim the study was evaluate immunogenicity an inactivated hepatitis A vaccine (HAV) IBD pediatric patients compared healthy controls.This open, prospective, and controlled anti-HAV-negative adolescents age 2-18 years IBD. HAV using 720 enzyme-linked immunosorbent assay (ELISA) units were administered at 0 months 6-12 months....
Most inflammatory bowel diseases (IBDs) are classic complex disorders represented by common alleles. Here we aimed to define the genetic architecture of pediatric and adult-onset IBDs for Polish population. A total 1495 patients were recruited, including 761 with Crohn's disease (CD; 424 pediatric), 734 ulcerative colitis (UC; 390 934 healthy controls. Allelotyping employed a pooled-DNA genome-wide association study (GWAS) was validated individual genotyping. Whole exome sequencing (WES)...
Celiac disease (CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically predisposed individuals, affecting about 1% general population developed world. In 2012, European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) recommendations CD diagnoses children adolescents were introduced, allowing "no-biopsy" approach if certain criteria met. This was also confirmed revised guidelines published 2020. Thus, aim this study to...
Abstract Primary biliary cholangitis (PBC), primary sclerosing (PSC), and inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) ulcerative colitis (UC), are heterogeneous chronic autoimmune that may share underlying pathogenic mechanisms. Herein, we compared simultaneously analyzed blood transcriptomes from patients with PBC, PSC, IBD. Microarray-based measurements were conducted using RNA isolated whole samples 90, 45, 95 93 CD, UC, respectively, 47 healthy controls. Expression...
Food allergy (FA) has a broad range of symptoms, and clinical manifestations may concern several reactions from one system or organ. The aim the study was to assess intestinal permeability (IP) based on analysis serum zonulin bacterial lipopolysaccharides (LPS) levels in children with FA, taking into account pathomechanism immune reaction, symptoms FA their severity. comprised 103 patients aged 7-60 months (median 34); 49 IgE-mediated 25 non-IgE-mediated allergy; reference group 29...
Objective. Inflammatory bowel disease (IBD) in children creates diagnostic and clinical challenges. Clinical data, endoscopic appearance the histopathological assessment of biopsies are essential for diagnosis. However, new methods required non-invasive follow-up. Recently, we demonstrated that dimeric isoform pyruvate kinase (PK) detected stool might serve as a potential screening tool inflamed pouch mucosa. The aim this study was to investigate whether test could be used detect intestinal...
Published epidemiologic data on the administration rates of enteral/parenteral home nutrition is very limited. The aim this first nationwide study was to assess availability pediatric enteral (HEN) services in Poland. questionnaire sent all regional centers providing HEN Poland (n = 14). analysis included number patients who received 2010, their demographic characteristics and geographical distribution. Furthermore, distributions indications methods were analyzed, along with reasons...
The aim of the study was to assess usefulness FC measurement in children with various types IBD and relation disease activity.91 patients (49 boys: 53.85% 42 girls: 46.15%, mean age: 13.38 years, range 6-18 years) were included analysis. Patients divided into groups: B1-24 CD, B2-16 UC, a group comprising 31 other colitis; control (K) comprised 20 healthy children. assayed by ELISA method, using Phical test (Calpro).The faecal calprotectin concentrations higher CD UC as compared controls,...
There are only a few studies on immune response to pneumococcal vaccines in patients with inflammatory bowel disease (IBD); all of them assessed polysaccharide only. The aim the study was evaluate immunogenicity and safety 13-valent conjugate vaccine (PCV13) IBD pediatric compared healthy controls.This multicenter, prospective, controlled children adolescents aged 5 18 years no history immunization. subjects for belonged one following groups: immunosuppressive therapy (group A), those tumor...
BACKGROUND:This study aimed to evaluate the C-reactive protein-to-albumin (CRP/albumin) ratio at diagnosis of pediatric inflammatory bowel disease (IBD). MATERIAL AND METHODS:Serum CRP/albumin was calculated for patients with Crohn's (CD; n=186) and ulcerative colitis (UC; n=159) aged 3-18 years. RESULTS:Patients CD differed in groups quiescent, mild, moderate, severe (P=0.011). significant differentiating from quiescent (area under curve (AUC)=0.94, odds (OR)=63.4, 95% confidence interval...
The study investigates the practical utility of whole-blood gene expression profiling to diagnose inflammatory bowel diseases [IBDs]. discovery cohorts included 102 and 51 paediatric IBD patients controls, 95 46 adult respectively. replication 447 76 271 108 In phase, RNA samples extracted from whole peripheral blood were analysed using RNA-Seq, predictive values selected biomarkers validated quantitative polymerase chain reaction [qPCR]. all, 15 differentially expressed transcripts...
The etiopathogenesis of inflammatory bowel disease (IBD) is multifactorial and not well explained. Environmental, genetic, dietary factors play an important role. aim the study was evaluation lactase, saccharase, maltase activity in patients with IBD.The comprised 65 children, aged 3-18 years. During a routine endoscopy, we took biopsies from descending part duodenum. In these biopsies, determined disaccharidase using Dahlquist's method.Decreased lactase taken small intestine mucosa most...
The results of studies assessing whether patients with Down syndrome have increased risk coeliac disease are contradictory. prevalence in is estimated at a wide range between 1% to as much 18.6%.To assess Poland.The study enrolled 301 from six centres Poland (Wroclaw, Sandomierz, Rzeszow, Grudziadz, Katowice, and Bydgoszcz). We measured the concentration anti-tissue transglutaminase IgA antibodies anti-deamidated gliadin peptide IgG all patients. Patients abnormal positive (> 10 U/ml) or...
The human leukocyte antigen (HLA) allele group HLA-DQA1*05 predisposes to ulcerative colitis (UC) and is associated with the development of antibodies against infliximab in patients inflammatory bowel disease (IBD). Therefore, we hypothesized that presence correlates characteristics pediatric IBD. Within a multi-center cohort Poland, phenotype at diagnosis worst flare was established status assessed enabling genotype-phenotype analyses. present 221 (55.1%) out 401 children IBD (UC n = 188,...
ABSTRACT Objectives: For breast‐fed infants with rectal bleeding, maternal restriction of dietary protein such as cow's milk proteins is often recommended; however, poor response to concern. This pilot study was designed assess the effectiveness Lactobacillus GG (LGG) in bleeding. Patients and Methods: Breast‐fed <6 months age bleeding (defined presence visible specks or streaks blood mixed mucus stool otherwise healthy infants) were enrolled a double‐blind randomized controlled trial...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Grzybowska-Chlebowczyk U, Jasielska M, Flak-Wancerz A, et al. Acute pancreatitis in children. Gastroenterology Review/Przegląd Gastroenterologiczny. 2018;13(1):69-75. doi:10.5114/pg.2017.70470. APA Grzybowska-Chlebowczyk, U., Jasielska, M., Flak-Wancerz, A., Więcek, S., Gruszczyńska, K., & Chlebowczyk, W. (2018). Gastroenterologiczny, 13(1), 69-75. https://doi.org/10.5114/pg.2017.70470 Chicago Urszula, Martyna...
The aim of this study was to evaluate the influenza vaccination status among paediatric patients with inflammatory bowel disease (IBD) in Poland. This a questionnaire-based study. 242 IBD and 142 controls were enrolled Of IBD, 7.8% received an vaccine, compared 18.3% (P = 0.0013). There no statistically significant differences time from diagnosis, activity drugs, between vaccinated non-vaccinated children. In conclusion, data our demonstrate alarmingly poor majority children IBD. Therefore,...