A5007131853- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Ovarian function and disorders
- Advances in Oncology and Radiotherapy
- Metabolomics and Mass Spectrometry Studies
- Multiple and Secondary Primary Cancers
- Diet, Metabolism, and Disease
- Reproductive Biology and Fertility
- Cancer Genomics and Diagnostics
- Thyroid Cancer Diagnosis and Treatment
- Birth, Development, and Health
- Growth Hormone and Insulin-like Growth Factors
- Economic and Financial Impacts of Cancer
- Cancer Mechanisms and Therapy
- IL-33, ST2, and ILC Pathways
- Neonatal and Maternal Infections
- Adipose Tissue and Metabolism
- Phytoestrogen effects and research
- Thyroid and Parathyroid Surgery
- Vascular anomalies and interventions
- Cancer, Hypoxia, and Metabolism
- Gestational Diabetes Research and Management
- Lung Cancer Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- BRCA gene mutations in cancer
Wroclaw Medical University
2018-2024
Poznan University of Medical Sciences
2014-2022
Greater Poland Cancer Center
2013-2020
The Maria Sklodowska-Curie National Research Institute of Oncology
2016-2019
Copernicus Memorial Hospital
2018
Centrum Onkologii
2013
University of Opole
2007
PCOS is a complex disorder and various features of this may have great importance for bone metabolism. The aim the study was to determine relationship between existing hormonal disorders, mineral density (BMD) in young women with PCOS.69 reproductive-aged 30 age-matched healthy controls were enrolled women. In each individual we assessed body mass index (BMI). We evaluated serum concentrations of: gonadotropins, prolactin (PRL), estradiol (E2), dehydroepiandrosterone sulfate (DHEAS),...
Most inflammatory bowel diseases (IBDs) are classic complex disorders represented by common alleles. Here we aimed to define the genetic architecture of pediatric and adult-onset IBDs for Polish population. A total 1495 patients were recruited, including 761 with Crohn's disease (CD; 424 pediatric), 734 ulcerative colitis (UC; 390 934 healthy controls. Allelotyping employed a pooled-DNA genome-wide association study (GWAS) was validated individual genotyping. Whole exome sequencing (WES)...
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in reproductive age women; it a complex health issue with numerous comorbidities. Attention has recently been drawn to amino acids as they are molecules essential maintain homeostasis. The aim study was investigate branch chain acid (BCAA) profile women PCOS. A total 326 women, 208 diagnosed PCOS and 118 healthy controls, participated study; all patients were between 18 40 years old. Anthropometrical, biochemical...
Genome-wide mechanisms that coordinate expression of subsets functionally related genes are largely unknown. Recent studies show receptor tyrosine kinases and components signal transduction cascades including the extracellular signal-regulated protein kinase (ERK), once thought to act predominantly in vicinity plasma membrane cytoplasm, can be recruited chromatin encompassing transcribed genes. distribution these transducers their relationship transcribing RNA polymerase II (Pol2) could...
Approximately 90% of colorectal cancer (CRC) deaths are caused by tumors ability to migrate into the adjacent tissues and metastase distant organs. More than 40 genes have been causally linked development CRC but no mutations associated with metastasis yet. To identify molecular basis we performed whole-exome genome-scale transcriptome sequencing 7 liver metastases along their matched primary tumours normal tissue. Multiple, spatially separated fragments were analyzed in each case. Uniformly...
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects reproductive-age women and predisposes them to the development of metabolic disturbances. Recent research has shown several factors may play role in PCOS pathogenesis, it been suggested an alteration amino acid profile might be predictive sign disorders. Metabolically healthy obesity (MHO) metabolically unhealthy (MUO) are concepts have attracted scientific attention; however, universal definition not established...
Introduction: Research on obesity, which results from excessive food consumption and sedentary lifestyle, has focused increasing energy expenditure. Recently, muscle tissue is being investigated as an endocrine active organ, secreting molecules called myokines. Multiple studies have been performed to assess myokine levels in various disorders, including polycystic ovary syndrome (PCOS) metabolic syndrome. Irisin Meteorin-like protein (Metrnl) are particles which, among others, suggested play...
The PALB2 gene encodes a protein that plays crucial role in maintaining genomic integrity. Germline inactivating mutations are associated with an increased risk of breast and ovarian cancer. prevalence spectrum recurrent germline cancer patients from Poland is not clearly defined. exons were amplified 460 BRCA1/2-mutation negative women familial and/or early-onset using AmpliSeq technology sequenced on Ion Torrent PGM sequencer. In addition, eight selected variants genotyped TaqMan assays...
Colorectal cancer (CRC) is the second most common in Europe and a leading cause of death worldwide. Patient-derived xenograft (PDX) models maintain complex intratumoral biology heterogeneity therefore remain platform choice for translational drug discovery. In this study, we implanted 37 primary CRC tumors five cell lines into NU/J mice to develop models. Primary established xenografts were histologically assessed surveyed genetic variants gene expression using panel 409 cancer-related genes...
The aim of the study was to characterize nutritional behavior in pregnancy.The survey included 250 pregnant women. concerned dietary refferedto type diet, number meals per day, snacking between meals, consumption meat, fish, dairy products,bread, fruits and vegetables.88.8% respondents were not on a special diet. most women ate more than three times day.The usually vegetables, yogurt sweets as snacks meals. majority respondentsconsumed meat sliced meats twice or once day with preference...
The prospero homeobox 1 (PROX1) transcription factor is a product of one the lymphangiogenesis master genes. It has also been suggested to play role in carcinogenesis, although its precise tumour development and metastasis remains unclear. aim this study was gain more knowledge on PROX1 function thyroid tumorigenesis. Follicular cancer-derived cells-CGTH-W-1-were transfected with PROX1-siRNA (small interfering RNA) their proliferation, cell cycle, apoptosis motility were then analysed....
There are many indications for breast augmentation, including reconstruction after mastectomy, correction of congenital disorders and cosmetic procedures. The most frequent local complication this surgery is capsule formation due to fibrosis. aim the study was assess usefulness sonoelastography in evaluation around silicone implants.The group included 13 patients aged 20 41, who underwent augmentation with implants. Their 26 breasts were examined before surgery, 7 14 days a minimum 8.5...
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies among women at reproductive age, but its pathology remains unknown. From epidemiological studies it known that endogenous, mainly genetic and exogenous, environmental factors are importance.The aim study was to compare phenotype diagnosed with PCOS from urban rural areas Poland. According knowledge authors, this first such study.The retrospective included 3,877 patients: 2511 living in cities 1,366 village...
1. Fauser BC, Tarlatzis Rebar RW et al. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Workshop Group. Fertil Steril. 2012; 97(1): 28–38. Google Scholar
The aim of the study was to compare perinatal outcome between normal weight, overweight and obese pregnant women who delivered in third-level center reference. Moreover, objective analyze usefulness predelivery body mass index (BMI) prediction preterm delivery, prolonged second stage labor, instrumental vaginal cesarean section, fetal macrosomia, dystocia newborn acidosis.The retrospective included 2104 patients, divided into three groups, with BMI 18.5 24.9; 25.0 29.9; higher than or equal...
Zachorowalność na infekcyjne zapalenie wsierdzia (IE) wzrasta w populacji dziecięcej, zwłaszcza u pacjentów z wrodzoną wadą serca. Właściwe postępowanie, diagnostyka, leczenie oraz właściwa profilaktyka pozostają przedmiotem wielu dyskusji. Leczenie chirurgiczne IE dzieci stanowi szczególne wyzwanie, głównie powodu małych rozmiarów pacjenta, konieczności zachowania potencjału do wzrostu i braku odpowiednich protez zastawkowych. W obliczu narastającego problemu należy zwiększać świadomość...
Celem pracy było określenie liczby chorych kierowanych do radioterapii Wielkopolskiego Centrum Onkologii z subregionów wielkopolski (poznański, pilski, koniński, leszczyński, kaliski), i porównanie ze współczynnikiem zachorowalności w roku 2013 województwie wielkopolskim.Dane o otrzymano kart napromieniania oraz systemu informatycznego Eskulap. Badaniem objęto 41 tygodni 2013. Stwierdzono lepszą dostępność subregionie poznańskim, porównaniu czterech pozostałych województwa wielkopolskiego:...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)