A5027298547- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Immunodeficiency and Autoimmune Disorders
- Gastroesophageal reflux and treatments
- Liver Diseases and Immunity
- Gastrointestinal motility and disorders
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Asthma and respiratory diseases
- Esophageal and GI Pathology
- Pregnancy and Medication Impact
- IL-33, ST2, and ILC Pathways
- Gastrointestinal disorders and treatments
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Digestive system and related health
- Autoimmune and Inflammatory Disorders Research
- Celiac Disease Research and Management
- Foreign Body Medical Cases
- Gastrointestinal Bleeding Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Mycobacterium research and diagnosis
- Adolescent and Pediatric Healthcare
Medical University of Warsaw
2014-2023
The Maria Sklodowska-Curie National Research Institute of Oncology
2000
The incidence of Crohn disease (CD) has been increasing and surgery needs to be contemplated in a substantial number cases. relevant advent biological treatment changed but not eliminated the need for many patients. Despite previous publications on indications CD, there was comprehensive review existing evidence role elective options pediatric patients affected with CD. We present an expert opinion critical literature provide evidence-based guidance manage these Indications, surgical...
The aim of the present study was to compare efficacy and safety 2 protocols maintenance therapy with infliximab (IFX) an immunomodulatory agent in pediatric patients Crohn disease (CD): withdrawal immunomodulators versus continuation immunosuppressants.The multicenter randomized open-label trial included 99 CD (ages 14.5 ± 2.6 years) who were administered IFX (5 mg/kg body weight) along (azathioprine 1.5-3 weight per day, methotrexate 10-25 mg/week). After 10 weeks induction therapy, 84...
Inflammatory bowel disease–unclassified (IBD-U) is diagnosed in ∼10% of pediatric and adolescent onset IBD patients. The EUROKIDS registry (2004) initiated by the Porto working group ESPGHAN prospectively monitors diagnostic workup newly We aimed to describe workup, phenotype, change diagnosis over time IBD-U Data were collected on children from 52 centers across 20 European countries Israel, with May 2005 through November 2013. Full endoscopy plus small radiology was considered complete...
There are only a few studies on immune response to routine vaccinations in children with inflammatory bowel disease (IBD), despite strong need for this kind of study. The aim the study was evaluate immunogenicity an inactivated hepatitis A vaccine (HAV) IBD pediatric patients compared healthy controls.This open, prospective, and controlled anti-HAV-negative adolescents age 2-18 years IBD. HAV using 720 enzyme-linked immunosorbent assay (ELISA) units were administered at 0 months 6-12 months....
Most inflammatory bowel diseases (IBDs) are classic complex disorders represented by common alleles. Here we aimed to define the genetic architecture of pediatric and adult-onset IBDs for Polish population. A total 1495 patients were recruited, including 761 with Crohn's disease (CD; 424 pediatric), 734 ulcerative colitis (UC; 390 934 healthy controls. Allelotyping employed a pooled-DNA genome-wide association study (GWAS) was validated individual genotyping. Whole exome sequencing (WES)...
The incidence of pediatric inflammatory bowel disease (IBD) in Western countries is on the rise. No prospective studies have been conducted epidemiology IBD Poland. aim study was to define characteristics new and assess among children Poland between 2002 2004.Patient records from 24 gastroenterology centers servicing whole population were collected. diagnosis based clinical, radiological, endoscopic histological features.There 491 patients, representing an overall 2.7 cases/100,000...
Abstract Primary biliary cholangitis (PBC), primary sclerosing (PSC), and inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) ulcerative colitis (UC), are heterogeneous chronic autoimmune that may share underlying pathogenic mechanisms. Herein, we compared simultaneously analyzed blood transcriptomes from patients with PBC, PSC, IBD. Microarray-based measurements were conducted using RNA isolated whole samples 90, 45, 95 93 CD, UC, respectively, 47 healthy controls. Expression...
There are only a few studies on immune response to pneumococcal vaccines in patients with inflammatory bowel disease (IBD); all of them assessed polysaccharide only. The aim the study was evaluate immunogenicity and safety 13-valent conjugate vaccine (PCV13) IBD pediatric compared healthy controls.This multicenter, prospective, controlled children adolescents aged 5 18 years no history immunization. subjects for belonged one following groups: immunosuppressive therapy (group A), those tumor...
The study investigates the practical utility of whole-blood gene expression profiling to diagnose inflammatory bowel diseases [IBDs]. discovery cohorts included 102 and 51 paediatric IBD patients controls, 95 46 adult respectively. replication 447 76 271 108 In phase, RNA samples extracted from whole peripheral blood were analysed using RNA-Seq, predictive values selected biomarkers validated quantitative polymerase chain reaction [qPCR]. all, 15 differentially expressed transcripts...
The aim of this study was to evaluate the influenza vaccination status among paediatric patients with inflammatory bowel disease (IBD) in Poland. This a questionnaire-based study. 242 IBD and 142 controls were enrolled Of IBD, 7.8% received an vaccine, compared 18.3% (P = 0.0013). There no statistically significant differences time from diagnosis, activity drugs, between vaccinated non-vaccinated children. In conclusion, data our demonstrate alarmingly poor majority children IBD. Therefore,...
There are limited data on antibody response to vaccination in patients with inflammatory bowel disease (IBD). In this study, we aimed assess the immunogenicity of a booster dose pertussis vaccine pediatric IBD and compare their healthy controls.We performed multicenter, prospective, controlled trial. Eligible for inclusion were children adolescents (11-18 year olds), no history immunization after age 6 years or pertussis. Study population was divided into 4 groups: receiving...
1. Shukla T, Singh S, Tandon P, McCurdy J. Corticosteroids and thiopurines, but not Tumor Necrosis Factor Antagonist, associated with Cytomegalovirus reactivation in Inflammatory Bowel Disease. A systemic review meta-analysis. J Clin Gastreonerol. 2017; 51: 394–401. CrossRef Google Scholar
In light of a paucity data on the role diet in colonoscopy preparation paediatric population, present study was designed to compare effectiveness clear liquid and low-fibre diets for breakfast lunch day preceding children.This prospective, randomised trial conducted at Department Paediatric Gastroenterology Nutrition Warsaw, Poland. Eligible patients, referred colonoscopies, were 6 18 years old. Patients randomly divided into 2 groups: first received second before colonoscopy. afternoon, all...
Iatrogenic viscus perforation in pediatric gastrointestinal endoscopy (GIE) is a very rare, yet potentially life-threatening event. There are no evidence-based recommendations relating to immediate post-procedure follow-up identify perforations and allow for timely management. This study aims characterize the presentation of children with post-GIE better rationalize recommendations.Retrospective based on unrestricted pooled data from centers throughout Europe, North America, Middle East...
Summary Background Although inflammatory bowel diseases (IBD) affect mainly the gastrointestinal tract, extra‐intestinal manifestations are not uncommon. Different diagnostic methods have been applied to assess pulmonary involvement in patients with IBD, but majority of these show significant limitations children. The aim our study was evaluate usefulness exhaled breath condensate (EBC) measurements pro‐inflammatory cytokines children IBD. Material and Methods Twenty‐two Crohn's disease (CD)...
<i>Background:</i> Prevention of <i>Helicobacter pylori</i> infection may help to control related gastritis, peptic ulcer and cancer. Of the possible preventive measures, immunization was successfully employed in various animal studies. However, no protocol has been accepted for humans. A better characterization immune response against pathogen be required before a human vaccine is developed. <i>Aim:</i> To identify bacterial proteins which induce an...
Disease knowledge is associated with increased treatment compliance and improvement of symptoms in inflammatory bowel disease (IBD). IBD-knowledge inventory device (IBD-KID) was developed validated specifically as a tool to measure disease-related children IBD their parents.
A 3-month-old girl was admitted for suspected upper gastrointestinal (GI) tract bleeding and emesis. She had 3 weeks of regurgitation days daily emesis, unassociated with meals, traces blood. good appetite, but lost weight from the 50th to 25th percentile. Omeprazole started on admission. Symptoms persisted 7 days. Hemoglobin normal stable. Upper endoscopy revealed a “cobblestone” appearance esophagus (Fig. 1). Biopsies severe esophagitis (no eosinophils) ulceration partial necrosis mucosa...
Abstract The aim of this study was to evaluate the serotype-specific pneumococcal status children and adolescents with inflammatory bowel disease (IBD) who were naïve vaccination before administering 13-valent conjugate vaccine (PCV 13). This an open, prospective on aged 5–18 years had IBD vaccination. A single dose PCV 13 administered each patient. geometric mean concentrations (GMCs) measured for all serotypes. total 122 subjects completed study. Prevaccination GMCs ranged from 0.55 μg/ml...