Urszula Demkow

ORCID: 0000-0003-0674-9824
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About
Contact & Profiles
Research Areas
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Asthma and respiratory diseases
  • Tuberculosis Research and Epidemiology
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Immune cells in cancer
  • Adipokines, Inflammation, and Metabolic Diseases
  • Mycobacterium research and diagnosis
  • Immune Response and Inflammation
  • Immune Cell Function and Interaction
  • Allergic Rhinitis and Sensitization
  • Pulmonary Hypertension Research and Treatments
  • Adipose Tissue and Metabolism
  • S100 Proteins and Annexins
  • Immunodeficiency and Autoimmune Disorders
  • Neonatal Respiratory Health Research
  • Systemic Sclerosis and Related Diseases
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Regulation of Appetite and Obesity
  • Vasculitis and related conditions
  • Sarcoidosis and Beryllium Toxicity Research
  • Diagnosis and treatment of tuberculosis
  • Viral gastroenteritis research and epidemiology
  • Food Allergy and Anaphylaxis Research
  • Genomics and Rare Diseases
  • Blood disorders and treatments

Medical University of Warsaw
2015-2024

Postgraduate School of Molecular Medicine
2016

Gdańsk Medical University
2016

University of Warsaw
2015

Institute of Psychiatry and Neurology
2014

Ege University
2014

Carol Davila University of Medicine and Pharmacy
2014

Children's Memorial Health Institute
2014

Centralny Szpital Kliniczny
2011

Instytut Gruźlicy i Chorób Płuc
1997-2008

Neutrophils are one of the first cells to arrive at site infection, where they apply several strategies kill pathogens: degranulation, respiratory burst, phagocytosis, and release neutrophil extracellular traps (NETs). Antibiotics have an immunomodulating effect, can influence properties numerous immune cells, including neutrophils. The aim this study was investigate effects azithromycin chloramphenicol on apoptosis, NETs by were isolated from healthy donors density-gradient centrifugation...

10.3390/ijms18122666 article EN International Journal of Molecular Sciences 2017-12-08

Abstract Studies on neutrophil extracellular traps ( NET s) are challenging as neutrophils live shortly and easily become activated. Thus, availability of a cell line model closely resembling the functions peripheral blood would be advantageous. Our purpose was to find compound that most effectively differentiates human promyelocytic leukemia (HL‐60) cells toward granulocyte‐like able release s. HL ‐60 were differentiated with all‐trans retinoic acid ATRA ), dimethyl sulfoxide DMSO ) or...

10.1111/imcb.12015 article EN Immunology and Cell Biology 2018-01-30

Despite great interest, the mechanism of neutrophil extracellular traps (NETs) release is not fully understood and some aspects this process, e.g. role reactive nitrogen species (RNS), still remain unclear. Therefore, our aim was to investigate mechanisms underlying RNS-induced formation NETs contribution RNS triggered by various physiological synthetic stimuli. The involvement in studied primary human neutrophils differentiated promyelocytic leukemia cells (HL-60 cells). (peroxynitrite...

10.1007/s00018-019-03331-x article EN cc-by Cellular and Molecular Life Sciences 2019-10-24

Since the SARS-CoV-2 outbreak, many countries have introduced measures to limit transmission. The data based on ICD-10 codes of lower respiratory tract infections and microbiological analysis gastrointestinal were collected. retrospective five-year medical records revealed a substantial decrease in during pandemic year (from April 2020 March 2021). We noted an 81% decline LRTI-associated hospital admissions mean 1170 per previous four years 225 between through According analysis, there 100%,...

10.3390/microorganisms10010178 article EN cc-by Microorganisms 2022-01-14

Atopic allergy is among the immune tolerance-related disorders resulting from a failure of regulatory network. Regulatory T cells (Tregs) play leading role in development homeostasis system. The aim this study was to determine Tregs pathogenesis atopic diseases children by exploring relationship between Treg frequency, activation markers and clinical manifestations disease.Twenty allergic 50 healthy were enrolled study. Peripheral blood mononuclear stained with monoclonal antibodies...

10.1159/000350769 article EN International Archives of Allergy and Immunology 2013-01-01
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