Grażyna Mierzwa

ORCID: 0000-0001-8954-6234
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About
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Research Areas
  • Helicobacter pylori-related gastroenterology studies
  • Eosinophilic Esophagitis
  • Gastroesophageal reflux and treatments
  • Inflammatory Bowel Disease
  • Microscopic Colitis
  • Digestive system and related health
  • Galectins and Cancer Biology
  • Nutrition and Health Studies
  • Autoimmune and Inflammatory Disorders Research
  • Immune Cell Function and Interaction
  • Complement system in diseases
  • IL-33, ST2, and ILC Pathways
  • Autoimmune and Inflammatory Disorders
  • Clinical Nutrition and Gastroenterology
  • Obesity, Physical Activity, Diet
  • Pregnancy and Medication Impact
  • Esophageal and GI Pathology
  • T-cell and B-cell Immunology
  • Education and Cultural Studies
  • Congenital gastrointestinal and neural anomalies
  • Vitamin D Research Studies
  • Catholicism, Bioethics, Media, Education
  • Medical and Biological Ozone Research
  • Metabolism and Genetic Disorders
  • Intestinal and Peritoneal Adhesions

Collegium Medicum in Bydgoszcz
2006-2022

Nicolaus Copernicus University
2006-2022

Pomeranian Medical University
2015

Children's Memorial Health Institute
2014

The aim of the present study was to compare efficacy and safety 2 protocols maintenance therapy with infliximab (IFX) an immunomodulatory agent in pediatric patients Crohn disease (CD): withdrawal immunomodulators versus continuation immunosuppressants.The multicenter randomized open-label trial included 99 CD (ages 14.5 ± 2.6 years) who were administered IFX (5 mg/kg body weight) along (azathioprine 1.5-3 weight per day, methotrexate 10-25 mg/week). After 10 weeks induction therapy, 84...

10.1097/mpg.0000000000000684 article EN Journal of Pediatric Gastroenterology and Nutrition 2015-01-07

Purpose. To investigate the expression of innate immunity components and cytokines in gastric mucosa among H. pylori infected uninfected children. Materials Methods. Biopsies antral from children with dyspeptic symptoms were evaluated. Gene expressions receptors measured by quantitative real-time PCR. The protein selected molecules was tested immunohistochemistry. Results. infection did not lead to a significant upregulation MyD88, TLR2, TLR4, CD14, TREM1, TREM2 mRNA but instead resulted...

10.1155/2015/176726 article EN cc-by Mediators of Inflammation 2015-01-01

Most inflammatory bowel diseases (IBDs) are classic complex disorders represented by common alleles. Here we aimed to define the genetic architecture of pediatric and adult-onset IBDs for Polish population. A total 1495 patients were recruited, including 761 with Crohn's disease (CD; 424 pediatric), 734 ulcerative colitis (UC; 390 934 healthy controls. Allelotyping employed a pooled-DNA genome-wide association study (GWAS) was validated individual genotyping. Whole exome sequencing (WES)...

10.1038/srep39831 article EN cc-by Scientific Reports 2016-12-23

Objective. The incidence of inflammatory bowel disease (IBD) in Europe has increased significantly. At least a fourth patients are children. Mannan-binding lectin (MBL) is believed to be an important component innate immunity, acting as opsonin and activator the pathway (LP) complement. data relating any LP factors IBD sparse contradictory were obtained mainly from adult patients. aim this study was investigate possible role MBL Crohn's (CD) ulcerative colitis (UC) Methods. MBL2 gene single...

10.3109/00365521.2011.594087 article EN Scandinavian Journal of Gastroenterology 2011-06-27

Background: In this study, H. pylori-infected and noninfected children with gastritis were compared to a control group respect circulating CD4+ CD8+ T lymphocytes expressing activation differentiation markers. Additionally, the lymphocyte phenotypes of correlated gastric inflammation scores. Materials Methods: pylori infection status was assessed based on [13C]urea breath test, rapid urease histology. Analysis surface molecule expression carried out by triple-color flow cytometry. Results:...

10.1111/j.1523-5378.2010.00809.x article EN Helicobacter 2011-01-17

Abstract Objectives: The aim of this study was to assess the cell surface expression adhesion (CD11a, CD11b, CD11c, CD18, CD54, and CD58) activation (CD14, HLA‐DR, CD16) molecules on circulating monocytes in Helicobacter pylori ( H. )‐infected noninfected children with gastritis, goal comparing results those obtained from controls. Materials Methods: Ninety‐four were studied: 47 them infection (of 25 after failure eradication therapy) 26 gastritis where excluded, as well 21 status assessed...

10.1111/j.1523-5378.2011.00932.x article EN Helicobacter 2012-03-20

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Kierkuś J, Sładek M, Pytrus T, et al. Clinical characteristics of 320 pediatric Crohn’s disease patients registered in the nationwide registry Poland. Gastroenterology Review/Przegląd Gastroenterologiczny. 2012;7(4):228-232. doi:10.5114/pg.2012.30507. APA Kierkuś, J., Sładek, M., Pytrus, T., Landowski, P., Czaja-Bulsa, G., & Ignyś, I. (2012). Gastroenterologiczny, 7(4), 228-232....

10.5114/pg.2012.30507 article EN cc-by-nc-sa Gastroenterology Review 2012-01-01

AMA Szaflarska-Popławska A, Popławski C, Mierzwa G. Utility of capsule endoscopy in children and youth – own experience. Gastroenterology Review/Przegląd Gastroenterologiczny. 2012;7(4):209-215. doi:10.5114/pg.2012.30504. APA Szaflarska-Popławska, A., Popławski, C., & Mierzwa, (2012). Gastroenterologiczny, 7(4), 209-215. https://doi.org/10.5114/pg.2012.30504 Chicago Anna, Cezary Grażyna Mierzwa. 2012. "Utility experience". Gastroenterologiczny 7 (4): Harvard pp.209-215. MLA Anna et al....

10.5114/pg.2012.30504 article EN cc-by-nc-sa Gastroenterology Review 2012-01-01

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Parzęcka M, Szaflarska-Popławska A, Mierzwa G, et al. Influence of Helicobacter pylori genetic type on gastroesophageal acid reflux disease in children and teenagers. Gastroenterology Review/Przegląd Gastroenterologiczny. 2010;5(3):151-156. doi:10.5114/pg.2010.14140. APA Parzęcka, M., Szaflarska-Popławska, A., Mierzwa, G., Gorzkiewicz, Łuczak, S., & Grzybowski, T. (2010). Gastroenterologiczny, 5(3), 151-156....

10.5114/pg.2010.14140 article EN cc-by-nc-sa Gastroenterology Review 2010-01-01

Introduction: Inflammatory bowel disease (IBD) is a group of diseases unexplained aetiology, characterized by periods remissions and exacerbations. Reactive oxygen species (ROS) as far disorders balance between levels prooxidants antioxidants may also participate in the occurrence IBD. The aim present study was an assessment antioxidative barrier organism patients with inflammatory disease. Material methods: consisted 99 (80 IBD 19 healthy control group) from Jan Biziel University Hospital...

10.5603/mrj.a2022.0044 article EN Medical Research Journal 2022-09-20

Physical activity strengthens the musculoskeletal system, prevents commonly known problems such as backache and degenerative changes of spine. Enhancing muscle strength reduces their load in daily activities. The increase flexibility agility along with balance decreases risk bone fractures osteo-articular system [10]. One main causes death Poland are cardiovascular diseases. is a relevant element prevention those diseases.The aim this study was evaluation fats consumption diet men training...

10.12775/mbs.2016.022 article EN Medical and Biological Sciences 2016-12-18
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