A5021927723- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Helicobacter pylori-related gastroenterology studies
- Inflammatory mediators and NSAID effects
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Peroxisome Proliferator-Activated Receptors
- Inflammatory Bowel Disease
- Drug-Induced Hepatotoxicity and Protection
- Gastrointestinal motility and disorders
- Eicosanoids and Hypertension Pharmacology
- Digestive system and related health
- Eosinophilic Esophagitis
- Microscopic Colitis
- Apelin-related biomedical research
- Hormonal Regulation and Hypertension
- Adenosine and Purinergic Signaling
- Hepatitis C virus research
- Gastrointestinal disorders and treatments
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Circadian rhythm and melatonin
- Celiac Disease Research and Management
Medical University of Lublin
2011-2020
University of Economics and Innovation
2015
Instytut Medycyny Wsi im. Witolda Chodźki
1994
Background:Non-alcoholic fatty liver disease (NAFLD) refers to a very wide clinical spectrum. Advanced fibrosis that accompanies leads the development of cirrhosis and hepatocellular carcinoma. Thus, identification patients with advanced is essential. The aim present study was compare usefulness NAFLD BARD scores in predicting determine risk factors fibrosis.Material/Methods:The included 126 NAFLD. Fibrosis biopsy scored on 5-point scale. were compared findings.Results:Liver revealed 27 99...
Abstract: Insulin resistance, oxidative stress, and an abnormal production of adipokines cytokines are implicated in the pathogenesis nonalcoholic steatohepatitis (NASH). Recently, we reported a significant improvement plasma liver enzymes among patients with NASH treated melatonin. In this study, investigated effect melatonin, administered at dose 10 mg/day for 28 days to 16 histologically proven on insulin resistance (HOMA‐IR), levels adiponectin, leptin, ghrelin, resistin. Additionally,...
Abstract: Melatonin and its precursor, l ‐tryptophan, have been shown to exert gastroprotective effects in animals, but their influence on the gastric damage by aspirin (ASA) humans has sparingly investigated. In this study, we designed determine of melatonin ‐tryptophan ASA‐induced mucosal damage, microbleeding, generation prostaglandin E 2 , plasma melatonin, gastrin levels. Three groups healthy male volunteers ( n = 30) with intact mucosa received daily for 11 days either ASA alone or...
Abstract: Melatonin and l ‐tryptophan (Trp) are highly gastroprotective in humans, but no study has assessed their impact on healing of chronic gastroduodenal ulcers humans. Three groups (A, B C) 14 idiopathic patients each treatment group with were treated omeprazole (20 mg twice daily) combined either placebo (group A), melatonin B) or Trp C). The rate ulcer was determined by gastroduodenoscopy at day 0, 7, 21 after initiation therapy. Plasma melatonin, gastrin, ghrelin leptin measured...
Objectives Mechanisms of immune regulation in alcoholic liver disease (ALD) are still unclear. The aim our study was to determine an impact Th17 / regulatory T (Treg) cells balance and its corresponding cytokine profile on the ALD outcome. Possible gender-related differences alcohol-induced inflammatory response were also assessed. Materials Methods 147 patients with prospectively recruited, assigned subgroups based their gender, severity dysfunction presence complications at admission,...
Abstract: This investigation was designed to assess the effects of oral administration melatonin (10 mg) and tryptophan (Trp) (500 on fasting postprandial plasma levels melatonin, gastrin, ghrelin, leptin insulin in 10 healthy controls age‐matched patients with liver cirrhosis (LC) portal hypertension. Fasting LC were about five times higher (102 ± 15 pg/mL) than (22 3 pg/mL). These significantly increased postprandially patients, but less so controls. Treatment or l ‐Trp resulted a further...
Interaction between TL1A and death receptor 3 (DR3) co-stimulates T cells, induces production of several pro-inflammatory cytokines has been linked to pathogenesis inflammatory bowel disease (IBD). This study aimed establish a link expression selected TL1A-induced involved in IBD (IL-4, IL-13, IL-17A IFN-γ) investigate connection serum concentration patients with activation peripheral blood cells. Elevated levels IL-4 (2.91-fold) IL-13 (4.05-fold) mRNA were detected the inflamed colon mucosa...
To investigate the effects of ADH and ALDH gene polymorphism on development alcoholism, alcohol liver cirrhosis chronic pancreatitis among Polish individuals.We determined allele genotype ADH2, ADH3 ALDH2 in 198 subjects: 57 with cirrhosis, 44 43 "healthy alcoholics"; 54 healthy non-drinkers served as controls. Genotyping was performed using polymerase chain reaction-restriction fragment length (PCR-RFLP) method white cell DNA.In population examined ADH2*1 frequency 97.97%. The tests did not...
Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn (CD). Similar symptoms, but different treatment procedures for both diseases require precise diagnosis. MicroRNAs (miRNAs) are major posttranscriptional players that regulate the expression of genes during inflammation thus could be appropriate biomarkers differentiation between UC CD. For this purpose, we analyzed miR-21-3p , miR-31-3p miR-125b-1-3p miR-146a-3p miR-155-5p E-cadherin ( CDH1) associated with IBD, in...
There is growing evidence that white adipose tissue an important contributor in the pathogenesis of alcoholic liver disease (ALD). We investigated serum concentrations total adiponectin (Acrp30), leptin, and resistin patients with chronic alcohol abuse different grades dysfunction, as well ALD complications.One hundred forty-seven consecutive inpatients were prospectively recruited. The evaluation plasma adipokine levels was performed using immunoenzymatic ELISA tests. Multivariable logistic...
Angiogenesis is believed to be implicated in the pathogenesis of alcoholic liver disease (ALD). We aimed explore usefulness and accuracy plasma angiogenic biomarkers for noninvasive evaluation severity failure ALD outcome. One hundred forty-seven patients with were prospectively enrolled assessed based on their (1) gender, (2) age, (3) dysfunction according Child-Turcotte-Pugh MELD scores, (4) presence complications. Plasma levels vascular endothelial growth factor (VEGF-A) angiopoietins 1 2...