A5005598295- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Galectins and Cancer Biology
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Digestive system and related health
- Hematological disorders and diagnostics
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
- Cancer-related gene regulation
- Cell death mechanisms and regulation
- Medical Imaging and Pathology Studies
- Protein Tyrosine Phosphatases
- Wnt/β-catenin signaling in development and cancer
- Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Sarcoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
Medical University of Białystok
2011-2020
Institute of Molecular Pathology and Pathomorphology
2010
University Clinical Hospital In Bialystok
1995
Wojewódzki Szpital Zespolony im. Jędrzeja Śniadeckiego
1994
Crohn’s disease (CD) and ulcerative colitis (UC) belong to a group of inflammatory bowel diseases (IBD). The aim our study was evaluate the expression MMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2 in disease. comprised 34 patients with UC 10 CD. Evaluation tissue samples performed using immunohistochemistry. overexpression MMP-9 TIMP-1 dominant both glandular epithelium infiltration patients. In contrast, CD subjects positive MMP-2 tubes while mainly MMP-7 infiltration. Metalloproteinases’ associated...
The objective of the study was assessment serum levels and tissue expression matrix metalloproteinase 2 (MMP-2) inhibitor metalloproteinases (TIMP-2) in patients with colorectal cancer (CRC). included 72 CRC 68 healthy subjects. MMP-2 TIMP-2 were measured using enzyme-linked immunosorbent assay (ELISA) method, whereas cells, interstitial inflammatory adjacent normal mucosa examined by immunohistochemical staining tumor samples. significantly lower than those control group, but percentage...
Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal disease, usually diagnosed in an advanced stage which gives slight chance of recovery. Matrix metalloproteinases (MMPs) are family zinc-dependent endopeptidases that participate tissue remodeling and stimulate neovascularization inflammatory response. The aim the study was to evaluate expression MMP-2, MMP-7, MMP-9 normal ducts, tumor pancreatic cells, peritumoral stroma correlation with clinicohistopathological parameters. material...
Background. Bcl-2 and BID play a major role in the process of apoptosis their dysfunction underlies carcinogenesis. The study objective was to assess expression gastric cancer cells correlation with chosen clinicopathological parameters, presence Helicobacter pylori infection, patients’ survival. Materials Methods. involved 88 patients operated on for cancer. expressions were determined immunohistochemically. Results. Positive found 55.7% and, 53.6% patients. correlated stage pT3 T4...
Most patients with gastric cancer are diagnosed at advanced clinical stages a high frequency of lymph node metastasis. It is very important to find novel factors for the early diagnostic and prognostic evaluation cancer. has been shown that IGF-1R activates mitotic division inhibits apoptosis cells through activation signaling MAP/ERK PI3K/Akt-1 pathways. plays role in cell transformation maintenance phenotype modified cells. Moreover, an IGF-1 receptor effect influences processes adhesion,...
Chronic kidney disease (CKD) is associated with disturbances in bone strength and metabolism. The alterations of the serotonergic system are also observed CKD. We used 5/6 nephrectomy model CKD to assess impact peripheral serotonin its metabolite- 5-hydroxyindoleacetic acid on biomechanical properties metabolism growing rats. animals were sacrificed one three months after nephrectomy. Biomechanical determined two different types: cortical femoral diaphysis using three-point bending test...
The current study objective was to assess the proliferation indices (PI) of Ki-67, PCNA and MCM2 proteins in advanced gastric cancer metastatic lymph node correlation with certain clinicopathological features postoperative survival patients. conducted a group 100 patients cancers. Involvement local nodes present 36 cases. Immunohistochemical investigations were carried out using monoclonal antibodies against Ki-67 (DAKO), (DAKO) polyclonal antibody (Santa Cruz Biotechnology). Visualization...
Degradation components of basement membrane could be crucial for tumor invasion. A key role in this process has been assigned to cysteine proteases, i.e. cathepsins and matrix metalloproteinases. The purpose study was investigate the relationship expression MMP-9 cathepsin B with aggressiveness expressed by lymph node metastases survival rates gastric carcinoma patients. Slides 5 mum-thick serial sections from 91 patients primary were prepared analyzed using anti-human monoclonal antibody...
The E-cadherin-catenin complex plays an important role in the process of cell adhesion. Its dysfunction is associated with a decrease differentiation and increased invasiveness metastasis. Our aim was to evaluate expression E-cadherin B-catenin advanced gastric cancer relation selected clinico-pathomorphological parameters. Formalin-fixed, paraffin-embedded tissue specimens were immunohistochemically stained monoclonal antibodies (NCL-E-Cad, Novocastra Laboratiries Ltd; dilution 1:50),...
Determination of the type mutations in gastrointestinal stromal tumours (GIST) plays a major role assessing risk progression disease, and also allows determination clinical management treatment. More accurate GIST diagnosis is possible by using simultaneously various types antibodies to immunohistochemistry methods routine procedures.To evaluate expression CD117, DOG-1, IGF-1R patients with tumours, analysis impact examined protein on patient survival emphasis specific recognition...
Abstract Background: Helicobacter pylori eradication from the oral cavity is more difficult than stomach. Thus, if bacterium survives antibacterial therapy in cavity, it would be able to re‐infect stomach within a few weeks. Since health status could correspond infection with H. , aim of study was determine whether and hygiene practices affect efficacy Material Methods: The performed 137 patients peptic ulcer who had undergone 7‐day course treatment one two sets drugs: 1, omeprazole,...
The objective of the current study was to assess expression Fas ligand (FasL) and receptor (FasR) as proteins post-mitochondrial apoptotic pathway in colorectal carcinoma investigate correlations between their chosen clinico-pathological parameters. protein analyzed 50 patients, using immunohistochemical method. Reaction for FasR weak 75.5% strong 24.5% compared normal glandular epithelium where 100% cases. On other hand, FasL found be 30% 70% cancer its lack epithelium. Statistical analysis...
Tissue inhibitor of metalloproteinase-1 (TIMP-1) inhibits the ability cancer cells to metastasize, but it can also stimulate development. The aim this study was assess level TIMP-1 in serum and its expression patients with colorectal (CRC). group consisted 43 diagnosed 24 healthy volunteers. assessed by ELISA method while protein performed immunohistochemically. concentration sera significantly higher than control (p = 0.004). Higher correlated female gender 0.045), tumor location colon...