A5082530237- Thyroid Cancer Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Estrogen and related hormone effects
- Prenatal Screening and Diagnostics
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- S100 Proteins and Annexins
- Toxic Organic Pollutants Impact
- Pregnancy and preeclampsia studies
- Effects and risks of endocrine disrupting chemicals
- Chemokine receptors and signaling
- Gestational Diabetes Research and Management
- Endometriosis Research and Treatment
- Genomic variations and chromosomal abnormalities
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Cell Adhesion Molecules Research
- Metabolism, Diabetes, and Cancer
- Blood Coagulation and Thrombosis Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Lymphatic System and Diseases
Medical University of Białystok
2016-2024
University Clinical Centre
2024
In physiological concentrations, reactive oxygen species play a vital role in regulating cell signaling and gene expression. Nevertheless, oxidative stress is implicated the pathogenesis of numerous diseases can inflict damage on diverse types tissues. Thus, understanding factors that mitigate deleterious effects imperative for identifying new therapeutic targets. light absence direct treatment recommendations reducing stress, there continuing need fundamental research utilizes innovative...
Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal disease, usually diagnosed in an advanced stage which gives slight chance of recovery. Matrix metalloproteinases (MMPs) are family zinc-dependent endopeptidases that participate tissue remodeling and stimulate neovascularization inflammatory response. The aim the study was to evaluate expression MMP-2, MMP-7, MMP-9 normal ducts, tumor pancreatic cells, peritumoral stroma correlation with clinicohistopathological parameters. material...
Circulating miRNAs are important mediators in epigenetic changes. These non-coding molecules regulate post-transcriptional gene expression by binding to mRNA. As a result, they influence the development of many diseases, such as gestational diabetes mellitus (GDM). Therefore, this study investigates changes miRNA profile GDM patients before hyperglycemia appears.
FSH receptor (FSHR), besides being expressed in gonads, is also some extragonadal tissues at low levels. We examined the functional expression of FSHR different types endometriotic lesions. Extensive studies were carried out to detect and FSH-stimulated estrogen production ovarian endometriomas recto-vaginal nodules (RVEN). Normal endometrium, ovary, myometrium from nonpregnant cycling women served as controls. This laboratory-based study was on tissue specimens patients with endometriosis...
Due to a global increase in the prevalence of type 2 diabetes mellitus (T2DM), there is an urgent need for early identification prediabetes, as these people have highest risk developing diabetes. Circulating miRNAs shown potential progression biomarkers other diseases. This study aimed conduct baseline comparison serum-circulating prediabetic individuals, with distinction between those who later progressed T2DM and did not. The expression levels 798 using NanoString technology were examined....
Abstract It is hypothesized that the oxidative stress level in thyroid cancer patients additionally upregulated by radioactive iodine (RAI) treatment, may exert an important impact on future health concerns. In our study, we evaluated changes using measurement of malondialdehyde (MDA) concentration with differentiated (DTC) undergoing RAI treatment. Considering results obtained study group, serum levels MDA DTC were significantly higher compared to healthy subjects ( p < 0.05). The was...
Abstract Angioinvasion remains the important prognostic feature in papillary thyroid cancer (PTC) patients. Literature data indicates several markers that may be associated with oxidative stress and/or angioinvasion. Therefore, we assessed utility of selected parameters angioinvasion and metastasis screening serum PTC Serum antioxidant capacity (TAC) sirtuin 3 (SIRT3) levels were decreased (all p < 0.05) both DNA/RNA damage products (DNA/RNA OSDP) malondialdehyde (MDA) increased patients...
Abstract Background Bisphenol A (BPA) is an estrogenic, endocrine-disrupting compound widely used in the industry. It also a ubiquitous environmental pollutant. Its presence was confirmed human fetuses, which results from maternal exposure during pregnancy. The mechanisms behind maternal-fetal transfer, and relationships between pregnant women fetal exposures remain unclear. aim of this study to assess impact BPA on fetus. Methods Maternal plasma amniotic fluid samples were collected 52...
The incidence of papillary thyroid cancer (PTC) has increased in recent years. To improve the diagnostic management PTC, we propose use microRNAs (miRNAs) as a biomarker. Our aim this study was to evaluate miRNA expression pattern PTC using NanoString technology. We identified ten miRNAs deregulated compared with reference tissue: miR-146b-5p, miR-221-3p, miR-221-5p, miR-34-5p, miR-551b-3p, miR-152-3p, miR-15a-5p, miR-31-5p, and miR-7-5p (FDR < 0.05; |fold change (FC)| ≥ 1.5). gene ontology...
Metalloproteinases (MMPs) are a group of proteolytic enzymes involved in the maintenance proper structure extracellular matrix (ECM). Matrilysins (MMP-7 and MMP-26) members MMPs that show promise as potential breast cancer (BC) markers. The aim study was to evaluate plasma levels MMP-7, MMP-26 CA 15-3 individually combination assess diagnostic utility studied matrilysins patients with BC. consisted 120 BC, control 40 subjects benign healthy women. Concentrations MMP-7 were determined by...
Total oxidative status (TOS), total antioxidant capacity (TAC), tumor protein 53 (p53), nuclear factor kappa B (NF-κB), forkhead box O1 (FOXO), and sirtuin 1 (SIRT1) play crucial roles in homeostasis the progression of papillary thyroid cancer (PTC), as previously demonstrated literature. Therefore, profiling these markers among PTC patients may be useful determining their eligibility for radioiodine (RAI) treatment. Since treatment indications are based on multiple dynamic recommendations,...
Macrophage colony-stimulating factor (M-CSF), matrix metalloproteinase-2 (MMP-2) and its specific tissue inhibitor (TIMP-2) may play an important role in the pathogenesis of cancer disease. We investigated plasma levels diagnostic power (ROC curve analysis) M-CSF, MMP-2, TIMP-2 tumor markers CA 125 SCC-Ag cervical (CC) patients as compared to control group. The study included 89 with cancer. group consisted 50 healthy, untreated women. MMP-2 were determined using ELISA, – by CMIA method....
The search of useful serum biomarkers for the early detection cervical cancers has been a high priority. activation Macrophage-Colony Stimulating Factor (M-CSF) and Vascular Endothelial Growth (VEGF) is likely involved in pathogenesis spread cancer. We compared plasma levels M-CSF VEGF to ones commonly accepted tumor markers CA 125and SCC-Ag three groups patients: 1. cancer group (patients with either squamous cell carcinoma or adenocarcinoma); 2. dysplasia group; 3. control group.This...
The increasing morbidity and mortality of type 2 diabetic mellitus (T2DM) patients with ischemic heart disease (IHD) highlight an urgent need to identify early biomarkers, which would help predict individual risk development IHD. Here, we postulate that circulating serum-derived micro RNAs (miRNAs) may serve as potential biomarkers for IHD diagnosis support the identification individuals a predisposition undergo We obtained serum samples from T2DM either or IHD-free analysed expression...
Aberrant metabolism has been identified as a main driver of cancer. Profiling metabolism-related pathways in cancer furthers the understanding tumor plasticity and identification potential metabolic vulnerabilities. In this prospective controlled study, we established transcriptomic profiles endometrial (EC) using novel method, NanoString nCounter Technology. Fifty-seven ECs 30 normal specimens were studied Metabolic Panel, further validated by qRT-PCR with very high similarity. Statistical...
Cytokines, metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) take part in many processes involved tumor progression invasion such as degradation of the extracellular matrix, influence on immune cells associated with tissue, angiogenesis. Thus, aim this study was to compare concentration plasma levels expression macrophage colony-stimulating factor (M-CSF), vascular endothelial growth (VEGF), matrix (MMP)-2 MMP9, TIMP1 TIMP2 patients cervical cancer, high-grade intraepithelial...
Abstract Context Papillary thyroid cancer (PTC) aggressiveness and metastatic potential are closely associated with angioinvasion. Identifying angioinvasion accurately is imperative for treatment planning prognosis. Objective This study explores serum biomarkers, including 8-hydroxydeoxyguanosine (8-OHdG) oxidative status markers (total capacity, total antioxidant capacity [TAC], sortilin), as indicators of in PTC. Design A cross-sectional involving 50 angioinvasive patients PTC (study...
Distinct miRNA expression patterns may reflect anomalies related to fetal congenital malformations such as spinal bifida (SB). The aim of this preliminary study was determine the maternal profile women carrying fetuses with SB. Therefore, six SB and twenty euploid healthy were enrolled in study. Using NanoString technology, we evaluated level 798 miRNAs both plasma amniotic fluid samples. A downregulation miR-1253, miR-1290, miR-194-5p, miR-302d-3p, miR-3144-3p, miR-4536-5p, miR-548aa +...