A5065403334- Thyroid Cancer Diagnosis and Treatment
- Prenatal Screening and Diagnostics
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- S100 Proteins and Annexins
- Ovarian function and disorders
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Gestational Diabetes Research and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive Biology and Fertility
- Regulation of Appetite and Obesity
- Cancer, Lipids, and Metabolism
- Cardiovascular Disease and Adiposity
- Parathyroid Disorders and Treatments
- Thyroid Disorders and Treatments
- Genomic variations and chromosomal abnormalities
- Pregnancy and preeclampsia studies
- Radiomics and Machine Learning in Medical Imaging
- Glutathione Transferases and Polymorphisms
- Cancer, Hypoxia, and Metabolism
- Biomarkers in Disease Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Peroxisome Proliferator-Activated Receptors
- Adrenal and Paraganglionic Tumors
Medical University of Białystok
2020-2024
In physiological concentrations, reactive oxygen species play a vital role in regulating cell signaling and gene expression. Nevertheless, oxidative stress is implicated the pathogenesis of numerous diseases can inflict damage on diverse types tissues. Thus, understanding factors that mitigate deleterious effects imperative for identifying new therapeutic targets. light absence direct treatment recommendations reducing stress, there continuing need fundamental research utilizes innovative...
Abstract It is hypothesized that the oxidative stress level in thyroid cancer patients additionally upregulated by radioactive iodine (RAI) treatment, may exert an important impact on future health concerns. In our study, we evaluated changes using measurement of malondialdehyde (MDA) concentration with differentiated (DTC) undergoing RAI treatment. Considering results obtained study group, serum levels MDA DTC were significantly higher compared to healthy subjects ( p < 0.05). The was...
Abstract Angioinvasion remains the important prognostic feature in papillary thyroid cancer (PTC) patients. Literature data indicates several markers that may be associated with oxidative stress and/or angioinvasion. Therefore, we assessed utility of selected parameters angioinvasion and metastasis screening serum PTC Serum antioxidant capacity (TAC) sirtuin 3 (SIRT3) levels were decreased (all p < 0.05) both DNA/RNA damage products (DNA/RNA OSDP) malondialdehyde (MDA) increased patients...
Oxidative stress (OS) plays a pivotal role in the pathogenesis of insulin resistance (IR), particularly its association with obesity. This study evaluate both diagnostic and clinical significance assessing oxidative status patients affected by overweight obesity displaying IR, especially reactive hypoglycemic episodes (RH). A comprehensive examination OS biomarkers was carried out, encompassing measurements total capacity (TOC) antioxidant (TAC). Our analysis results reveal noteworthy...
Women with polycystic ovary syndrome (PCOS) are at an increased risk of developing insulin resistance and abdominal obesity in the state improper diet balance. Leptin is a peptide considered to be satiety hormone that plays important role long-term energy balance, whereas ghrelin controls short-term appetite regulation hunger hormone. The aim present study was assess relationship between serum leptin concentrations dietary macronutrient content PCOS women. We examined 73 subjects: 39 women...
The incidence of papillary thyroid cancer (PTC) has increased in recent years. To improve the diagnostic management PTC, we propose use microRNAs (miRNAs) as a biomarker. Our aim this study was to evaluate miRNA expression pattern PTC using NanoString technology. We identified ten miRNAs deregulated compared with reference tissue: miR-146b-5p, miR-221-3p, miR-221-5p, miR-34-5p, miR-551b-3p, miR-152-3p, miR-15a-5p, miR-31-5p, and miR-7-5p (FDR < 0.05; |fold change (FC)| ≥ 1.5). gene ontology...
Total oxidative status (TOS), total antioxidant capacity (TAC), tumor protein 53 (p53), nuclear factor kappa B (NF-κB), forkhead box O1 (FOXO), and sirtuin 1 (SIRT1) play crucial roles in homeostasis the progression of papillary thyroid cancer (PTC), as previously demonstrated literature. Therefore, profiling these markers among PTC patients may be useful determining their eligibility for radioiodine (RAI) treatment. Since treatment indications are based on multiple dynamic recommendations,...
The aim of this study was to compare the aqueous humor (AH) and serum concentrations metabolites in diabetic (n = 36) nondiabetic senior adults undergoing cataract surgery. Blood samples were collected before surgery AH during Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)-based targeted metabolomic lipidomic analyses performed using AbsoluteIDQ® p180 kit. Out 188 by kit, 41 133 detected >80% samples, respectively. Statistical analysis indicate differentiating...
Aberrant metabolism has been identified as a main driver of cancer. Profiling metabolism-related pathways in cancer furthers the understanding tumor plasticity and identification potential metabolic vulnerabilities. In this prospective controlled study, we established transcriptomic profiles endometrial (EC) using novel method, NanoString nCounter Technology. Fifty-seven ECs 30 normal specimens were studied Metabolic Panel, further validated by qRT-PCR with very high similarity. Statistical...
Abstract Context Papillary thyroid cancer (PTC) aggressiveness and metastatic potential are closely associated with angioinvasion. Identifying angioinvasion accurately is imperative for treatment planning prognosis. Objective This study explores serum biomarkers, including 8-hydroxydeoxyguanosine (8-OHdG) oxidative status markers (total capacity, total antioxidant capacity [TAC], sortilin), as indicators of in PTC. Design A cross-sectional involving 50 angioinvasive patients PTC (study...
Distinct miRNA expression patterns may reflect anomalies related to fetal congenital malformations such as spinal bifida (SB). The aim of this preliminary study was determine the maternal profile women carrying fetuses with SB. Therefore, six SB and twenty euploid healthy were enrolled in study. Using NanoString technology, we evaluated level 798 miRNAs both plasma amniotic fluid samples. A downregulation miR-1253, miR-1290, miR-194-5p, miR-302d-3p, miR-3144-3p, miR-4536-5p, miR-548aa +...
Abstract Context Brain-derived neurotrophic factor (BDNF) concentrations may differ between BDNF genotype carriers. These changes occur in individuals with metabolic and mental disorders. Objective The aim of this study was to assess the associations glucose homeostasis parameters frequency food consumption protein based on single nucleotide polymorphisms (SNPs). Methods Among 439 participants, some common rs10835211 gene variants were analyzed. We evaluated concentrations, measured insulin...
Phloroglucinol (PHG), an analgesic and spasmolytic drug, shows promise in preventing high-fat-diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) insulin resistance. In Wistar rats, 10 weeks of PHG treatment did not prevent HFD-induced weight gain but significantly mitigated fasting hyperglycemia, impaired responses, steatosis. This protective effect was linked to hepatic lipogenesis or AMP-activated protein kinase (AMPK) activation. Instead, improved mitochondrial function by...