Background: In pulmonary arterial hypertension (PAH), there is still a need for new prognostic markers to precisely identify patients before clinical deterioration. We investigated the right ventricle cardiac power index (RV CPI) as tool assess RV function. also hypothesized that hemodynamic changes occurring in PAH assessed with CPI are related metabolism alterations PET imaging, which affects prognosis. Methods: Twenty-eight stable (51.4 ± 15.9 years old) had PET/CMR and heart...

Purpose. To assess FGF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>, TGF-<mml:math id="M2"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>, and COX2 expression immunocompetent cells in the orbital tissue of patients with severe mild Graves’ orbitopathy. Patients Methods. Orbital was taken from 27 GO: (1) GO (<mml:math id="M3"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>18</mml:mn></mml:math>), mean clinical activity...

Abstract It is hypothesized that the oxidative stress level in thyroid cancer patients additionally upregulated by radioactive iodine (RAI) treatment, may exert an important impact on future health concerns. In our study, we evaluated changes using measurement of malondialdehyde (MDA) concentration with differentiated (DTC) undergoing RAI treatment. Considering results obtained study group, serum levels MDA DTC were significantly higher compared to healthy subjects ( p &lt; 0.05). The was...

Abstract Angioinvasion remains the important prognostic feature in papillary thyroid cancer (PTC) patients. Literature data indicates several markers that may be associated with oxidative stress and/or angioinvasion. Therefore, we assessed utility of selected parameters angioinvasion and metastasis screening serum PTC Serum antioxidant capacity (TAC) sirtuin 3 (SIRT3) levels were decreased (all p &lt; 0.05) both DNA/RNA damage products (DNA/RNA OSDP) malondialdehyde (MDA) increased patients...

<i >Introduction</i>. The aim of the present study was to compare levels circulating markers endothelial function and low-grade inflammation in patients with subclinical overt hyperthyroidism (OH) due Graves disease (GD) toxic nodular goiter (TNG). >Material Methods</i>. group studied consisted 42 GD, 75 TNG, 39 healthy controls. >Results</i>. Circulating dysfunction were elevated both SH OH, but concentrations interleukin-12 (IL-12) (<svg style="vertical-align:-0.1638pt;width:58.712502px;"...

Objective Right ventricular (RV) function is a major determinant of survival in patients with pulmonary arterial hypertension (PAH). Metabolic alterations may precede haemodynamic and clinical deterioration. Increased RV fluorodeoxyglucose (FDG) uptake positron emission tomography (PET) was recently associated progressive dysfunction MRI, but the prognostic value their combination has not been established. Methods Twenty-six clinically stable PAH (49.9±15.2 years) 12 healthy subjects...

Total oxidative status (TOS), total antioxidant capacity (TAC), tumor protein 53 (p53), nuclear factor kappa B (NF-κB), forkhead box O1 (FOXO), and sirtuin 1 (SIRT1) play crucial roles in homeostasis the progression of papillary thyroid cancer (PTC), as previously demonstrated literature. Therefore, profiling these markers among PTC patients may be useful determining their eligibility for radioiodine (RAI) treatment. Since treatment indications are based on multiple dynamic recommendations,...

It was recently suggested that genetic factors could play a major role in the development of Graves' disease (GD). The aim present study to evaluate frequency c.721G-->A polymorphism and c.1405A-->G intercellular adhesion molecule 1 (ICAM-1) gene subjects with GD compared healthy controls, because ICAM-1 found key lymphocyte infiltration into thyroid gland concentration soluble form correlates significantly clinical activity treatment status GD. We have analyzed association polymorphisms age...

Purpose. To evaluate the relationship between expression of orbital tissue mRNA for FOXP3, CTLA-4/CD28/CD80/CD86, and CD40/CD40 severity Graves’ orbitopathy (GO). Material Methods. Orbital was obtained from 26 patients with GO, mild (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>6</mml:mn></mml:math>) or severe GO id="M2"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>20</mml:mn></mml:math>), 7 healthy controls. The CD40/CD40L...

In pulmonary arterial hypertension (PAH) increased afterload leads to adaptive processes of the right ventricle (RV) that help maintain arterio-ventricular coupling RV and preserve cardiac output, but with time mechanisms fail. this study, we propose a multimodal approach which allows estimate prognostic value parameters in PAH patients. Twenty-seven stable patients (49.5 ± 15.5 years) 12 controls underwent cardiovascular magnetic resonance (CMR). CMR feature tracking analysis was performed...

PET/MRI hybrid imaging in pulmonary arterial hypertension (PAH) provides important prognostic information identifying patients who might benefit from early therapy escalation, as right ventricle (RV) metabolic alterations are linked with hemodynamics and precede clinical deterioration. Now, we hypothesize that adequate PAH escalation may result reversal of unfavourable increased glucose uptake RV, which is associated improved prognosis.Out twenty-six initially clinically stable had baseline...

Activated CD4 T cells' express CD40 ligand (CD154) interacting with on the B cells surface, protecting them from Fas-mediated apoptosis and in this study, influence humoral response. The aim of study was to assess soluble CD154 Graves' disease (GD) Hashimoto's thyroiditis (HT) relation Fas FasL markers response: aTPO, aTG aTSHR. carried out 5 groups subjects: 1/14 patients GD euthyreosis methimazol (euGD), 2/20 hyperthyroid (hrGD), 3/15 HT levothyroxine (euHT), 4/16 hypothyroid Ht (hoHT),...

Radioiodine ((131)I) isotope therapy is the method of choice in treatment Graves' disease relapse. The efficiency this dependent on many factors; therefore, present paper aims to identify parameters that have a crucial impact efficacy radioiodine for disease.The authors performed retrospective analysis medical documentation 700 sufferers treated with (131)I. patients were divided into three groups depending thyroid-absorbed dose (131)I: group I - 100 Gy, II 150 and III 200 Gy. assessed...

The most frequently used methods of assessing Graves' orbithopathy (GO) include: Clinical Activity Score (CAS), ultrasonography (USG), computed tomography (CT), and magnetic resonance imaging (MRI). There exists another, slightly forgotten, method: single-photon emission (SPECT) with the use diethylenetriaminepentaacetic acid tagged 99mTc (99mTc-DTPA). These days it is possible to conduct a SPECT examination fused CT scan (SPECT/CT), which increases diagnostic value investigation. aim this...

The aim of the study was to assess usefulness circulating chemokines CXCL9 and CXCL10 measurements as surrogate markers GO activity a guideline in therapeutic decision-making. Forty-two individuals were divided into 4 groups: 1. 15 euthyroid patients with clinical symptoms orbitopathy (GO) who underwent corticosteroid therapy consisting intravenous infusions methylprednisolone (MP) teleradiotherapy (TR); 2. 10 hyperthyroid GD (Gtx); 3. euthyreosis (Geu); 4. 7 healthy volunteers age...

The use of 18F-PSMA-1007 and the role PET/MR in diagnosis prostate cancer are not conclusively confirmed. There reports indicating potential pros cons using as well technique recurrence, but they yet included EAU guidelines. aim study was to assess effectiveness detecting BCR lesions at very low PSA levels &lt;0.5 ng/mL. Methods: Sixty patients with after radical prostatectomy (RP) ranged 0.1–0.5 ng/mL were enrolled a prospective study. All underwent simultaneous whole-body pelvic PET/MR....

Graves' orbitopathy (GO) is characterized by orbital T cell infiltration. We evaluated the regulatory (Treg) fractions induced with IGF-1 in disease (GD) and without GO. Peripheral blood mononuclear cells (PBMCs) were obtained from 13 patients GD eye manifestations; 10 active GO; 12 nodular goiter (NG). All GD, GO, NG subclinical hyperthyroid. analyzed expression of Treg markers (CD4, CD25, CD127^–, Foxp3) on their ability to respond stimulation. In we found lowered percentages...

To evaluate if conjunctival epithelial cells’ expression of HLA-DR and ICAM-1 could be helpful as early topical markers inflammation in Graves’ orbitopathy (GO). The ocular examination evaluated a clinical activity score (CAS) by assessment features, (e.g., eyelid or inflammation, lid width, closure, proptosis, motility). Conjunctival cell specimens for flow-cytometric evaluations ICAM-I HLADR were collected impression cytology from ten eyes with active GO (CAS ≥ 4 duration ≤ 12 months), 15...

Autoimmune diseases are a group of complex localized in multiple organ systems, with wide spectrum symptoms and still unclear causes. The aim the present study was to analyse possible association three autoimmune disabilities - Multiple sclerosis (MS), LADA diabetes Graves' disease (GD) single nucleotide polymorphism (SNP; rs1990760) IF IH1 gene (also known as melanoma differentiation-associated protein 5 MDA5) within Polish population. An additional goal also look for correlation between...

Introduction: Assessment of the renin-angiotensin-aldosterone system has been recently granted a much greater role in evaluation patients with arterial hypertension. There is no single test efficient selection for second-step etiological investigation. Methods: Altogether, 198 consecutive − 119 women (60%) and 79 men (40%) – hospitalized years 2009–2011 at Clinical Department Endocrinology Medical University Bialystok were diagnosed primary aldosteronism. In each patient, plasma renin...