A5042263322- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Glaucoma and retinal disorders
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Gestational Diabetes Research and Management
- Advanced Proteomics Techniques and Applications
- Platelet Disorders and Treatments
- Mass Spectrometry Techniques and Applications
- Retinal Diseases and Treatments
- Diet, Metabolism, and Disease
- Mitochondrial Function and Pathology
- Birth, Development, and Health
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Genomics and Diagnostics
- Metabolism and Genetic Disorders
- RNA modifications and cancer
- Inflammatory Bowel Disease
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Prenatal Screening and Diagnostics
- Traditional Chinese Medicine Analysis
Medical University of Białystok
2016-2025
University Clinical Centre
2022
Hudson Institute
2018
John Wiley & Sons (United Kingdom)
2018
Medical University of Lodz
2017
Police Department
2014
Universidad San Pablo CEU
2010-2013
John Paul II Catholic University of Lublin
2010
Universidad Autónoma de Madrid
2010
Institute of Physical Chemistry
2008
Lipids are important components of biological systems, and their role can be currently investigated by the application untargeted, holistic approaches such as metabolomics lipidomics. Acquired data analyzed to find significant signals responsible for differentiation between conditions. Subsequently, identification has performed bring meaning obtained results. Lipid seems relatively easy due known characteristic fragments; however, large number structural isomers formation different adducts...
Metabolic profiling might be used to identify disease biomarkers. The aim of our study was determine the usefulness untargeted metabolomics analysis detect differences in serum metabolites between newly diagnosed and untreated pediatric patients with Crohn's (CD) or ulcerative colitis (UC) comparison a control group (Ctr). Moreover, we investigated potential inflammatory markers improve noninvasive diagnosis CD UC children. fingerprinting samples estimated liquid chromatography coupled mass...
Application of high-throughput technologies in metabolomics studies increases the quantity data obtained, which turn imposes several problems during analysis. Correctly and clearly addressed biological question comprehensive knowledge about structure properties are definitely necessary to select proper chemometric tools. However, there is a broad range tools available for use with data, makes this choice challenging. Precisely performed treatment enables valuable extraction information its...
Abstract Metabolomics combined with machine learning methods (MLMs), is a powerful tool for searching novel diagnostic panels. This study was intended to use targeted plasma metabolomics and advanced MLMs develop strategies diagnosing brain tumors. Measurement of 188 metabolites performed on samples collected from 95 patients gliomas (grade I–IV), 70 meningioma, 71 healthy individuals as control group. Four predictive models diagnose glioma were prepared using 10 conventional approach. Based...
Abdominal aortic aneurysm (AAA) is a permanent and localized dilation, defined as diameter ≥3 cm. It an asymptomatic but potentially fatal condition because progressive enlargement of the abdominal aorta spontaneously evolving towards rupture. Biomarkers may help to explain pathological processes AAA expansion, allow us find novel therapeutic strategies or determine efficiency current therapies. Metabolomics seems be good approach biomarkers AAA. In this study, plasma samples patients with...
Accurate post-mortem interval (PMI) estimation is essential in forensic investigations. Although various methods for PMI determination have been developed, only an approximate still achievable, and accurate indication challenging. Therefore, this study, we employed gas chromatography-mass spectrometry (GC-MS)-based metabolomics to assess changes porcine blood samples collected with without the addition of anticoagulant (EDTA). Our study aimed identify metabolites dependent on EDTA time...
An association between gut microbiota and the development of pancreatic ductal adenocarcinoma (PDAC) has been previously described. To better understand bacterial changes accompanying PDAC promotion progression stimulated by inflammation fecal transplantation (FMT), we investigated stool 16s RNA-based metagenomic analysis in mice with inducible acinar transgenic expressions KrasG12D, age- sex-matched control that were exposed to inflammatory stimuli obtained from PDAC. Time-...
Metabolites can lead to novel discoveries in cardiovascular disease (CVD). The aim of the study was investigate whether a metabolomic profile is associated with mortality patients coronary artery (CAD). group consisted 170 participants CAD who were hospitalized due acute syndrome or elective percutaneous intervention 12-26 months before evaluation (mean[SD] months, 16.3 [2.2]). A total 132 metabolites profiled by liquid chromatography-tandem mass spectrometry, and sums/ratios 102 metabolite...
Ozonated autohemotherapy (O3-AHT) is a medical approach during which blood obtained from the patient ozonated and injected back into body. Despite an increasing number of evidence that O3-AHT safe, this type therapy remains controversial. To extend knowledge about changes in evoked by O3-AHT, LC–MS- GC–MS-based metabolic fingerprinting was used to compare plasma samples before after treatment with potentially therapeutic concentrations ozone. The procedure performed PVC bags utilized for...
Large-scale meta-analyses of genome-wide association studies have recently confirmed that the rs340874 single-nucleotide polymorphism in PROX1 gene is associated with fasting glycemia and type 2 diabetes mellitus; however, mechanism this link was not well established. The aim our study to evaluate functional/phenotypic differences related variants. group comprised 945 subjects Polish origin (including 634 BMI > 25) without previously known dysglycemia. We analyzed behavioral patterns (diet,...
The interactions between lifestyle and genetic factors play an important role in obesity development. Mutations melanocortin-4-receptor (MC4R) gene are one of the most common cause monogenic obesity, however, functional effects polymorphic variants near MC4R general populations remain uncertain. aim our study was to analyze whether single nucleotide polymorphisms (SNPs) influence food preferences, physical activity, body fat content distribution, as well fasting postprandial energy...