A5021934710- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Fatty Acid Research and Health
- Pancreatic and Hepatic Oncology Research
- Cellular Mechanics and Interactions
- Muscle metabolism and nutrition
- Neurotransmitter Receptor Influence on Behavior
- Nutrition and Health in Aging
- Cannabis and Cannabinoid Research
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Disease and Adiposity
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Lipid metabolism and biosynthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Lung Cancer Treatments and Mutations
Medical University of Białystok
2018-2025
University Clinical Centre
2022
An association between gut microbiota and the development of pancreatic ductal adenocarcinoma (PDAC) has been previously described. To better understand bacterial changes accompanying PDAC promotion progression stimulated by inflammation fecal transplantation (FMT), we investigated stool 16s RNA-based metagenomic analysis in mice with inducible acinar transgenic expressions KrasG12D, age- sex-matched control that were exposed to inflammatory stimuli obtained from PDAC. Time-...
The major risk factors of T2DM (type 2 diabetes mellitus) development are still under investigation. We evaluate the possible associated with type (T2DM) in adult subjects during a five-year prospective cohort study. recruited 1160 who underwent oral glucose tolerance test, anthropometric measurements, and body composition fat distribution analysis at baseline visit again follow-up after approximately five years. conclusions this study based on observation 219 attended both first visits....
Introduction: Discrimination between adenocarcinoma (ADC) and squamous cell carcinoma (SCC) subtypes in non-small lung cancer (NSCLC) patients is a significant challenge oncology. Lipidomics analysis provides promising approach for this differentiation. Methods: In an accompanying paper, we explored oxPCs levels cohort of 200 NSCLC patients. research, utilized liquid chromatography coupled with mass spectrometry (LC-MS) to analyze the lipidomics profile matching tissue plasma samples from 25...
An investigation of new ways to activate brown adipose tissue (BAT) is highly valuable, as it a possible tool for obesity prevention and treatment. The aim our study was evaluate the relationships between dietary intake BAT activity. group comprised 28 healthy non-smoking males aged 21-42 years. All volunteers underwent physical examination 75-g OGTT completed 3-day food diaries macronutrients fatty acid intake. Body composition measurements were assessed using DXA scanning. FDG-18 PET/MR...
Fascins are a group of proteins taking part in the maintenance proper structure cellular cytoskeleton. Fascin-1 is an actin-bundling protein present neurons, fibroblasts, endothelial, smooth muscle, dendritic and mesenchymal cells whereas lack its expression characteristic epithelial cells. overexpression can be observed neoplastic Therefore, aim this study was to assess patients with colorectal cancer (CRC) analyze associations between ex-pression clinical-pathological parameters.The...
The unique ability of brown adipocytes to increase metabolic rate suggests that they could be targeted as an obesity treatment. objective the study was search for new dietary factors may enhance adipose tissue (BAT) activity. group comprised 28 healthy non-smoking males, aged 21-42 years old. All volunteers underwent a physical examination and 75 g oral glucose tolerance test (75g-OGTT). Serum atrial brain natriuretic peptide (ANP, BNP), PRD1-BF1-RIZ1 homologous domain containing 16 (PRDM16)...
Changes in serum or plasma metabolome may reflect gut microbiota dysbiosis, which is also known to occur patients with prediabetes and type 2 diabetes (T2DM). Thus, developing a robust method for the analysis of microbiota-dependent metabolites (MDMs) an important issue. Gas chromatography mass spectrometry (GC-MS) powerful approach enabling detection wide range MDMs biofluid samples good repeatability reproducibility, but requires selection suitable solvents conditions. For this reason, we...
Although brown adipose tissue (BAT) is considered to play a protective role against obesity and type 2 diabetes, the mechanisms of its activation associations with clinical parameters are not well described. Male adults underwent h cold exposure (CE) activate BAT and, based on results PET/MRI performed after CE, were divided into BAT(+) BAT(-) groups. During CE procedure, blood samples collected alterations in plasma metabolome both groups investigated using LC-MS. Additionally, between...
Introduction: Recent data suggest a possible role of endocannabinoids in the regulation brown adipose tissue (BAT) activity. Those findings indicate potential treatment options for obesity. The aim this study was to evaluate relationship between plasma concentrations and presence BAT humans. Methods: group consisted 25 subjects divided into two groups: positive BAT(+), (n = 17, median age years) negative BAT(-), 8, 28 years). estimated using 18F-FDG PET/MR after 2 h cold exposure. level...
Introduction: Pancreatic cancer is characterized by its aggressiveness and poor prognosis. Furthermore, mortality one of the highest among all types cancers. It has been observed that expression Fascin-1 (the actin-bundling protein which enables motility cells) higher in cells correlated with invasiveness metastasis. Purpose: To investigate histopathological specimens from patients treated for pancreatic relationship parameters. Materials methods: The study was performed on a group 52...