A5082421651- Protease and Inhibitor Mechanisms
- Chemokine receptors and signaling
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Antibiotics Pharmacokinetics and Efficacy
- S100 Proteins and Annexins
- Escherichia coli research studies
- Cancer, Lipids, and Metabolism
- T-cell and B-cell Immunology
- Antibiotic Resistance in Bacteria
- Invertebrate Immune Response Mechanisms
- Bone and Dental Protein Studies
- Immune Cell Function and Interaction
- Ovarian cancer diagnosis and treatment
- Connective Tissue Growth Factor Research
Medical University of Białystok
2017-2021
The aim of this study was to investigate plasma levels and applicability CCL2, CCR2, tumor marker CA 15-3 in breast cancer (BC) patients relation the control groups: with benign healthy subjects. Plasma tested parameters were determined by enzyme-linked immunosorbent assay (ELISA) Chemiluminescent Microparticle Immunoassay (CMIA). median CCL2 entire group BC significantly higher compared groups, similarly as 15-3. CCR2 is a negative whose lower women. concentration increases advancing stage,...
Metalloproteinases (MMPs) are a group of proteolytic enzymes involved in the maintenance proper structure extracellular matrix (ECM). Matrilysins (MMP-7 and MMP-26) members MMPs that show promise as potential breast cancer (BC) markers. The aim study was to evaluate plasma levels MMP-7, MMP-26 CA 15-3 individually combination assess diagnostic utility studied matrilysins patients with BC. consisted 120 BC, control 40 subjects benign healthy women. Concentrations MMP-7 were determined by...
Cytokines, metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) take part in many processes involved tumor progression invasion such as degradation of the extracellular matrix, influence on immune cells associated with tissue, angiogenesis. Thus, aim this study was to compare concentration plasma levels expression macrophage colony-stimulating factor (M-CSF), vascular endothelial growth (VEGF), matrix (MMP)-2 MMP9, TIMP1 TIMP2 patients cervical cancer, high-grade intraepithelial...
Fascins are a group of proteins taking part in the maintenance proper structure cellular cytoskeleton. Fascin-1 is an actin-bundling protein present neurons, fibroblasts, endothelial, smooth muscle, dendritic and mesenchymal cells whereas lack its expression characteristic epithelial cells. overexpression can be observed neoplastic Therefore, aim this study was to assess patients with colorectal cancer (CRC) analyze associations between ex-pression clinical-pathological parameters.The...
The aim of the study was to identify new non-invasive ovarian cancer (OC) tumor markers.In postmenopausal patients and in a control group (benign lesions healthy subjects), preoperative plasma levels cytokines, metalloproteinases their tissue inhibitors were determined using ELISA while those CA125 HE4 by chemiluminescent microparticle immunoassay methods.The diagnostic sensitivity (SE) value highest for MMP-7 (78.0%). specificity (SP) M-CSF, VEGF MMP-9 95.2%, 95.2% 95.7%, respectively....
Background/Aim: Chemokines are cytokines involved not only in inflammatory but also inappropriate response of the immune system breast cancer (BC) progression. We examined diagnostic usefulness CXCL12, CXCR4 and CA 15-3 BC patients, based on ROC curve analysis. Materials Methods: The study group consisted 100 patients with BC; control 35 women benign disease healthy patients. median concentration chemokines was measured by ELISA that chemiluminescent microparticle immunoassay. Results:...
Abstract Background: Metalloproteinases (MMPs) are a group of proteolytic enzymes involved in the maintenance proper structure extracellular matrix (ECM). Matrilysins (MMP-7 and MMP-26) one MMPs that could represent potential breast cancer (BC) markers. The aim study was to evaluate plasma levels MMP-7, MMP-26 CA 15-3 individually combination assess diagnostic utility studied matrilysins BC patients. Methods: consisted 120 patients with BC, control 40 benign healthy women. Concentrations...
Background: Stromelysins are potential breast cancer biomarkers. The aim of the study was to evaluate if plasma levels selected metalloproteinases (MMPs) (stromelysin-1 (MMP-3) and stromelysin-10 (MMP-10)) antigen 15-3 (CA 15-3) used separately in combination demonstrated diagnostic usefulness (BC). Methods: group consisted 120 patients with BC, while control included 40 benign healthy individuals. Concentrations MMP-3 MMP-10 were determined by enzyme-linked immunosorbent assay; CA...
The chemokine CCL5 and its receptor CCR5 play important roles in cancer invasion metastasis. Based on our knowledge, results were the first that presented diagnostic usefulness of breast (BC) patients, based receiver operating characteristic (ROC) curve analysis. We wished to examine further if are appropriate be applied as BC markers for early screening. Values tested parameters patients’ plasma determined by CMIA method (Chemiluminescent Microparticle Immunoassay, CA 15-3) well ELISA...