A5025223229- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Cancer Genomics and Diagnostics
- Infections and bacterial resistance
- Antibiotic Use and Resistance
- Lung Cancer Treatments and Mutations
- Pharmaceutical and Antibiotic Environmental Impacts
- Enterobacteriaceae and Cronobacter Research
- Molecular Biology Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Bacterial Identification and Susceptibility Testing
- Gene expression and cancer classification
- Healthcare Systems and Public Health
- Biomedical and Engineering Education
- Vibrio bacteria research studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Meat and Animal Product Quality
- Cell Image Analysis Techniques
- Iron Metabolism and Disorders
- Advanced Proteomics Techniques and Applications
- Health, Environment, Cognitive Aging
Medical University of Białystok
2013-2025
Nicolaus Copernicus University
2024
Collegium Medicum in Bydgoszcz
2024
The ESCPM group (Enterobacter species including Klebsiella aerogenes - formerly Enterobacter aerogenes, Serratia species, Citrobacter freundii complex, Providencia and Morganella morganii) has not yet been incorporated into systematic surveillance programs. We conducted a multicentre retrospective observational study analysing all strains isolated from blood cultures in 27 European hospitals over 3-year period (2020-2022). Diagnostic approach, epidemiology, antimicrobial susceptibility were...
Bacteria belonging to the Enterobacteriaceae family that produce extended-spectrum β -lactamase (ESBL) enzymes are important pathogens of infections. Increasing numbers ESBL-producing bacterial strains exhibiting multidrug resistance have been observed. The aim study was evaluate prevalence of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Biobanks are vital for high-throughput translational research, but the rapid development of novel molecular techniques, especially in omics assays, poses challenges to traditional practices and recommendations. In our study, we used biospecimens from oncological patients Polish clinics collaborated with Indivumed Group. For serum/plasma samples, monitored hemolysis, controlled RNA extraction, assessed cDNA library quality quantity, verified NGS raw data. Tissue samples underwent pathologic...
A comparative analysis of blood samples (depleted albumin and IgG) obtained from lung cancer patients before chemotherapy versus after a second cycle was performed using two-dimensional difference gel electrophoresis (2D-DIGE). The control group consisted eight with non-cancerous diseases, the experimental four adenocarcinoma (ADC) squamous cell carcinoma (SCC) patients. Analyses gels revealed significant changes in proteins and/or their proteoforms between patients, both chemotherapy. Most...
Non-small cell lung cancer (NSCLC) encompasses distinct histopathological subtypes, namely adenocarcinoma (AC) and squamous carcinoma (SCC), which require precise differentiation for effective treatment strategies. In this study, we present a novel molecular diagnostic model that integrates tissue-specific expression profiles of microRNAs (miRNAs) obtained through next-generation sequencing (NGS) to discriminate between AC SCC subtypes NSCLC. This approach offers more comprehensive...
The present study was conducted to investigate the prevalence of genes encoding resistance aminoglycosides and fluoroquinolones among twenty-five Pseudomonas aeruginosa isolated between 2002 2009. In PCR, following were detected: ant(2")-Ia in 9 (36.0%), aac(6')-Ib 7 (28.0%), qnrB 5 (20.0%), aph(3")-Ib 2 (8.0%) isolates.
Introduction: Discrimination between adenocarcinoma (ADC) and squamous cell carcinoma (SCC) subtypes in non-small lung cancer (NSCLC) patients is a significant challenge oncology. Lipidomics analysis provides promising approach for this differentiation. Methods: In an accompanying paper, we explored oxPCs levels cohort of 200 NSCLC patients. research, utilized liquid chromatography coupled with mass spectrometry (LC-MS) to analyze the lipidomics profile matching tissue plasma samples from 25...
Advances in molecular analyses based on high-throughput technologies can contribute to a more accurate classification of non–small cell lung cancer (NSCLC), as well better prediction both the disease course and efficacy targeted therapies. Here we set out analyze whether global gene expression profiling performed group early-stage NSCLC patients classifying tumor subtypes predicting prognosis. Gene was with use microarray technology training 108 samples. Subsequently, recorded findings were...
Lung cancer is responsible for the most cancer-related mortality worldwide and mechanism of its development poorly understood. Proteomics has become a powerful tool offering vital knowledge related to development. Using two-dimensional difference gel electrophoresis (2D-DIGE) approach, we sought compare tissue samples from non-small-cell lung (NSCLC) patients taken tumor center margin. Two subtypes NSCLC, adenocarcinoma (ADC) squamous cell carcinoma (SCC) were compared. Data are available...
The utility of carbapenems, which are considered 'last-line' agents, is being diminished by the growing incidence various resistance mechanisms in bacteria. We aimed to investigate molecular mechanism carbapenem Enterobacter cloacae recovered from a 76-year-old patient who had undergone coronary artery bypass grafting and repair mitral tricuspid valves. Interestingly, no prior history hospital admission abroad.The Carba-NP test II synergy testing were performed confirm carbapenemase...
Lychnis flos-cuculi L., Caryophyllaceae, contains a number of active compounds belonging to several chemical groups. Previous studies have led the identification phytoecdysteroids, triterpenoids saponins, volatile compounds, fatty acid derivatives, phenolic acids and flavonoids. Research on pharmacological activity showed that plant extracts inhibited growth bacteria fungi. The antimitotic properties preparations from herb L. were also reported. phytochemical analyses demonstrated this taxon...
The effectiveness of carbapenems, considered as last-resort antimicrobials in severe infections, becomes compromised by bacterial resistance. production metallo-β-lactamases (MBLs) is the most significant threat to carbapenems activity among Pseudomonas aeruginosa. aim this study was assess presence and type MBLs genes carbapenem-resistant P. aeruginosa clinical strains, identify location determine genetic relatedness between MBL-producers using pulsed-field gel electrophoresis (PFGE)...
3064 Background: In recent years, the use of tumor molecular profiling in clinical settings has enhanced cancer diagnostics, as well delivery precision oncology. Recently, several methods for predicting gene expression directly from Haematoxylin-and-Eosin-stained (H&E) histology images have offered a new way to leverage easily obtainable and cost-effective H&E multiple oncology applications. We previously introduced such method – DeepPT demonstrated how we can its imputed successful...
Chryseobacterium indologenes is an environmental organism and uncommon human pathogen. This causes opportunistic infections in patients with severe underlying clinical conditions. C. are problematic because of decreased therapeutic options attributable to bacterial resistance antibiotics, which mainly depend on the production specific IND type metallo-β-lactamases. We report a case blood sample obtained from patient adenocarcinoma. The was treated 1.2-g dose Augmentin three times day....