A5072021711- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Protein Structure and Dynamics
- Molecular Biology Techniques and Applications
- Machine Learning in Bioinformatics
- Traditional Chinese Medicine Studies
- Biofuel production and bioconversion
- Forensic Entomology and Diptera Studies
- Escherichia coli research studies
- Biochemical and Structural Characterization
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Anaerobic Digestion and Biogas Production
- Genomics and Phylogenetic Studies
- Antimicrobial Peptides and Activities
- Bee Products Chemical Analysis
- Artificial Intelligence in Healthcare
- RNA modifications and cancer
- Microbial Metabolic Engineering and Bioproduction
- Glycosylation and Glycoproteins Research
- Gene expression and cancer classification
- Spectroscopy Techniques in Biomedical and Chemical Research
- Galectins and Cancer Biology
- Protein Hydrolysis and Bioactive Peptides
Medical University of Białystok
2024-2025
University of Wrocław
2018-2022
Brandenburg University of Technology Cottbus-Senftenberg
2021
Antimicrobial peptides (AMPs) are molecules widespread in all branches of the tree life that participate host defense and/or microbial competition. Due to their positive charge, hydrophobicity and amphipathicity, they preferentially disrupt negatively charged bacterial membranes. AMPs considered an important alternative traditional antibiotics, especially at time when multidrug-resistant bacteria being on rise. Therefore, reduce costs experimental research, robust computational tools for AMP...
NanoString nCounter is a medium-throughput technology used in mRNA and miRNA differential expression studies. It offers several advantages, including the absence of an amplification step ability to analyze low-grade samples. Despite its considerable strengths, popularity platform experimental research stabilized 2022 2023, this trend may continue upcoming years. Such stagnation could potentially be attributed standardized analytical pipeline or indication optimal processing methods for data...
Missing values are commonly observed in metabolomics data from mass spectrometry. Imputing them is crucial because it assures completeness, increases the statistical power of analyses, prevents inaccurate results, and improves quality exploratory analysis, modeling, machine learning. Numerous Value Imputation Algorithms (MVIAs) employ heuristics or models to replace missing information with estimates. In context data, we identified 52 MVIAs implemented across 70 R functions. Nevertheless,...
Accurate post-mortem interval (PMI) estimation is essential in forensic investigations. Although various methods for PMI determination have been developed, only an approximate still achievable, and accurate indication challenging. Therefore, this study, we employed gas chromatography-mass spectrometry (GC-MS)-based metabolomics to assess changes porcine blood samples collected with without the addition of anticoagulant (EDTA). Our study aimed identify metabolites dependent on EDTA time...
Information about the impact of interactions between amyloid proteins on their fibrillization propensity is scattered among many experimental articles and presented in unstructured form. We manually curated information located almost 200 publications (selected out 562 initially considered), obtaining details 883 experimentally studied 46 or peptides. also proposed a novel standardized terminology for description amyloid-amyloid interactions, which included our database, covering all...
Summary The vast biodiversity of the microbial world and how little is known about it, has already been revealed by extensive metagenomics analyses. Our rudimentary knowledge microbes stems from difficulties concerning their isolation culture in laboratory conditions, which necessary for describing phenotype, among other things, biotechnological purposes. An important component understudied ecosystems methanogens, archaea producing a potent greenhouse‐effect gas methane. Therefore, we...
Pathogenic bacteria, such as enteropathogenic Escherichia coli (EPEC) and enterotoxigenic E. (ETEC), cause diarrhea in mammals. In particular, colonizes infects the gastrointestinal tract via type 1 fimbriae (T1F). Here, major zymogen granule membrane glycoprotein 2 (GP2) acts a host cell receptor. GP2 is also secreted by pancreas various mucous glands, interacting with luminal fimbriae-positive coli. It unknown whether isoforms demonstrate specific pathotype binding. this study, we...
Signal peptides are N-terminal presequences responsible for targeting proteins to the endomembrane system, and subsequent subcellular or extracellular compartments, consequently condition their proper function. The significance of signal stimulates development new computational methods detection. These employ learning systems trained on datasets comprising from different types taxonomic groups. As a result, accuracy predictions high in case that well-represented databases, but might be low...
Abstract Several disorders are related to amyloid aggregation of proteins, for example Alzheimer’s or Parkinson’s diseases. Amyloid proteins form fibrils aggregated beta structures. This is preceded by formation oligomers—the most cytotoxic species. Determining amyloidogenicity tedious and costly. The reliable identification amyloids obtained with high resolution microscopies, such as electron microscopy atomic force (AFM). More frequently, less expensive faster methods used, especially...
DNA double-strand breaks can be counted as discrete foci by imaging techniques. In personalized medicine and pharmacology, the analysis of counting data is relevant for numerous applications, e.g., cancer aging research evaluation drug efficacy. By default, it assumed to follow Poisson distribution. This assumption, however, may lead biased results faulty conclusions in datasets with excess zero values (zero-inflation), a variance larger than mean (overdispersion), or both. such cases,...