A5012377992- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Circular RNAs in diseases
- Parathyroid Disorders and Treatments
- Bone health and osteoporosis research
- Sleep and Wakefulness Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Lipid Membrane Structure and Behavior
- Bone health and treatments
- Sphingolipid Metabolism and Signaling
- Diabetes and associated disorders
- MicroRNA in disease regulation
Medical University of Białystok
2021-2022
Circulating miRNAs are important mediators in epigenetic changes. These non-coding molecules regulate post-transcriptional gene expression by binding to mRNA. As a result, they influence the development of many diseases, such as gestational diabetes mellitus (GDM). Therefore, this study investigates changes miRNA profile GDM patients before hyperglycemia appears.
We hypothesized that sphingolipids may be early biomarkers of gestational diabetes mellitus (GDM). Here, 520 women with normal fasting plasma glucose levels were recruited in the first trimester and tested a 75 g oral tolerance test 24th-28th week pregnancy. Serum concentrations measured second by ultra-high performance liquid chromatography coupled triple quadrupole mass spectrometry (UHPLC/MS/MS) 53 patients who diagnosed GDM, as well 82 pregnant (NGT) 32 non-pregnant women. In trimester,...
The purpose of this study was to assess the clinical usefulness assaying fibroblast growth factor (FGF-23), Klotho, osteocalcin, N-terminal telopeptide type I collagen (NTX), and sclerostin levels in patients with primary hyperparathyroidism (PHPT) as markers bone damage well for surgical treatment success. Seventeen hypercalcemic PHPT normal kidney function were studied. In all patients, PTH (parathormone), serum calcium, creatinine performed before six months after parathyroidectomy (PTX)....