A5012559880- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Digestive system and related health
- Inflammatory Bowel Disease
- Gastroesophageal reflux and treatments
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Celiac Disease Research and Management
- Galectins and Cancer Biology
- Pancreatitis Pathology and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Esophageal and GI Pathology
- Liver Diseases and Immunity
- Immunodeficiency and Autoimmune Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Infant Nutrition and Health
- Veterinary medicine and infectious diseases
- Microbial Metabolites in Food Biotechnology
- Viral gastroenteritis research and epidemiology
- Gastrointestinal motility and disorders
- Pediatric health and respiratory diseases
- Clostridium difficile and Clostridium perfringens research
- Hepatitis Viruses Studies and Epidemiology
- Pregnancy and Medication Impact
- Blood groups and transfusion
Wroclaw Medical University
2014-2023
University of Wrocław
2010-2023
Medical University of Białystok
2014
Centrum Leczenia Oparzeń
2013
Szpital Kliniczny Nr 1 we Wrocławiu
2013
Amsterdam UMC Location University of Amsterdam
2013
Niepubliczna Wyższa Szkoła Medyczna
2006-2011
Nutrition Sciences (Belgium)
2007
Institute of Mathematics
2002
There are no solid figures of the frequency ulcer disease during childhood in Europe. We assessed its and analyzed known risk factors. Patients methods Ulcers, erosions, indications, factors were recorded all children undergoing an upper gastrointestinal endoscopy a prospective study carried out 1-month simultaneously 19 centers among 14 European countries. Results Ulcers and/or erosions observed 56 694 children. Children with ulcers/erosions significantly older than those without lesions...
The aim of the present study was to compare efficacy and safety 2 protocols maintenance therapy with infliximab (IFX) an immunomodulatory agent in pediatric patients Crohn disease (CD): withdrawal immunomodulators versus continuation immunosuppressants.The multicenter randomized open-label trial included 99 CD (ages 14.5 ± 2.6 years) who were administered IFX (5 mg/kg body weight) along (azathioprine 1.5-3 weight per day, methotrexate 10-25 mg/week). After 10 weeks induction therapy, 84...
Recently published data indicate that the inflammation in Crohn's disease (CD) may be accompanied by elevated levels of matrix metalloproteinases. The goals present study were estimation MMP-3 and -9 concentrations sera children with disease, examination correlation between clinical activity relation to control group evaluation utility concentration measurements as markers activity. Serum estimated 82 (45 CD patients divided into severe, moderate mild subgroups; 37 controls) correlated...
There are only a few studies on immune response to routine vaccinations in children with inflammatory bowel disease (IBD), despite strong need for this kind of study. The aim the study was evaluate immunogenicity an inactivated hepatitis A vaccine (HAV) IBD pediatric patients compared healthy controls.This open, prospective, and controlled anti-HAV-negative adolescents age 2-18 years IBD. HAV using 720 enzyme-linked immunosorbent assay (ELISA) units were administered at 0 months 6-12 months....
The increasing number of pediatric patients infected with multiresistant Helicobacter pylori strains calls for evaluation treatment regimens. Second-line antibiotics such as tetracycline or quinolones are not licensed children. Because in vivo resistance to metronidazole may be overcome by a high dose and prolonged intake, we evaluated the eradication rate side effects high-dose triple therapy culture-proven double resistance.In this open multicentre trial, 62 children (<18 years, body...
The enhanced activity of matrix endopeptidases (MMPs) involved in the degradation connective tissue has been noted samples from digestive tract inflammatory bowel disease (IBD), however sera concentrations MMPs, a potential tool for diagnostic tests IBD patients, have not established so far. goal studies was to evaluate MMP-3 and MMP-9, children suffering ulcerative colitis (UC) relation activity.The study comprised 31 with UC (aged 3-18 years) 37 control group 1-18 years). Disease estimated...
Most inflammatory bowel diseases (IBDs) are classic complex disorders represented by common alleles. Here we aimed to define the genetic architecture of pediatric and adult-onset IBDs for Polish population. A total 1495 patients were recruited, including 761 with Crohn's disease (CD; 424 pediatric), 734 ulcerative colitis (UC; 390 934 healthy controls. Allelotyping employed a pooled-DNA genome-wide association study (GWAS) was validated individual genotyping. Whole exome sequencing (WES)...
The goal of first-line Helicobacter pylori therapy is to reach an eradication rate 90% avoid further investigations, antibiotic use, and spreading resistant strains.To evaluate the high-dose sequential in treatment-naïve children assess factors associated with failure.Prospective data assessed a registry from nine European centers between October 2009 December 2011. Children biopsy-proven infection were prescribed 5 days esomeprazole amoxicillin, followed by esomeprazole, clarithromycin,...
Abstract Primary biliary cholangitis (PBC), primary sclerosing (PSC), and inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) ulcerative colitis (UC), are heterogeneous chronic autoimmune that may share underlying pathogenic mechanisms. Herein, we compared simultaneously analyzed blood transcriptomes from patients with PBC, PSC, IBD. Microarray-based measurements were conducted using RNA isolated whole samples 90, 45, 95 93 CD, UC, respectively, 47 healthy controls. Expression...
The resistance of microorganisms to antibiotics has become a serious issue in recent years the therapy bacterial infections. This problem also concerns treatment infections caused by Helicobacter pylori strains. aim this study was evaluate frequency primary H. strains isolated from children and adults. subject research 105 60 adults Lower Silesia Region 2008-2011. Antimicrobial susceptibility following assessed: amoxicillin (AC), clarithromycin (CH), metronidazole (MZ), tetracycline (TC),...
ABSTRACT Objectives: The aim of the study was to assess clinical presentation, endoscopic findings, antibiotic susceptibility and treatment success Helicobacter pylori ( H. ) infected pediatric patients. Methods: Between 2013 2016, 23 hospitals from 17 countries prospectively submitted data on consecutive ‐infected (culture positive) patients EuroPed HP‐ Registry. Results: Of 1333 recruited (55.1% girls, median age 12.6 years), 1168 (87.6%) were therapy naïve (group A) 165 (12.4%) had failed...
Various testing methods are successfully applied to the diagnosis of Helicobacter pylori infection, but noninvasive techniques still needed for therapeutic monitoring, especially in children. In search new H. authors evaluated an enzyme immunoassay detection antigen stool (HpSA).The studied 62 pylori-positive children with chronic gastritis and 45 control subjects. infection was diagnosed using cultures histology gastric biopsy specimens a test before treatment (clarithromycin, amoxicillin,...
To analyze risk factors associated with gastro-duodenal ulcers and erosions in children.Open, prospective, multicenter, case-control study carried out 11 European countries patients gastric or duodenal ulcers/erosions 2 age-matched controls each. Possible were recorded. Logistic regression models performed adjustment for centers age groups.Seven-hundred thirty-two (244 cases, 153 only 91 ulcers, 488 controls) recruited. Children receiving antimicrobials acid suppressive drugs before...
The study investigates the practical utility of whole-blood gene expression profiling to diagnose inflammatory bowel diseases [IBDs]. discovery cohorts included 102 and 51 paediatric IBD patients controls, 95 46 adult respectively. replication 447 76 271 108 In phase, RNA samples extracted from whole peripheral blood were analysed using RNA-Seq, predictive values selected biomarkers validated quantitative polymerase chain reaction [qPCR]. all, 15 differentially expressed transcripts...
Lactase is an enzyme involved in the hydrolysis of lactose. Deficiency (hypolactasia) may be determined genetically or arise secondarily to disease small intestine. Under this condition, lactose enters colon where it fermented by intestinal microflora and turns gases short-chain fatty acids, causing gastrointestinal symptoms known as intolerance (LI).To investigate incidence malabsorption (LM), LI coexistence these two conditions children with upper tract diseases (UGTD), syndrome,...
Background. In recent years, food allergy, especially in the child population, has become an increasing problem developed societies. youngest children, it is a frequent cause of gastrointestinal disorders. The atopy patch test, applied from several years clinical practice, one methods used allergology.Objectives. objective work was assessment diagnostic value test diagnosis allergy to cow's milk protein and wheat proteins children with symptoms.Material Methods. study comprised 61 (37 boys...
Infection with Helicobacter pylori is a major cause of chronic gastritis and peptic ulcer disease in children its consequences adulthood can lead to serious complications, including particular the development gastric cancer. Our aim was analyze relationship between occurrence selected genes such as cagA, vacA, iceA, babA2 determining pathogenicity H. strains clinical outcome children.The study performed on isolated from biopsies taken 130 adolescents non-ulcer dyspepsia (NUD), duodenal...
ABSTRACT Objective: The aim of the study was to assess safety and efficacy high‐ low‐dose oral, delayed‐release mesalamine in a randomized, double‐blind, active control children with mild‐to‐moderately ulcerative colitis. Methods: Patients ages 5 17 years, Pediatric Ulcerative Colitis Activity Index (PUCAI) score ≥10 ≤55 truncated Mayo Score ≥1 for both rectal bleeding stool frequency, were enrolled. They received body weight–dependent doses 6 weeks low‐ (27–71 mg · g −1 day ) or high‐dose...